IncidencePrevalence

Estimate Incidence and Prevalence in OMOP CDM

Overview

  • The basics
  • Interface
  • More information

The Basics

  1. Denominator population

  2. Incidence rates

  3. Prevalence

    • Point prevalence

    • Period prevalence

Denominator population

Observation periods


Denominator population

Observation periods + study period


Denominator population

Observation periods + study period + prior history requirement


Denominator population

Observation periods + study period + prior history requirement + age (and sex) restriction


Incidence rates

Washout all history, no repetitive events


Incidence rates

No washout, no repetitive events


Incidence rates

Some washout, no repetitive events


Incidence rates

Some washout, repetitive events


Prevalence

Point prevalence


Prevalence

Period prevalence


Overview

  • Concepts
  • Interface
  • More information

Required packages

install.packages("IncidencePrevalence")

generateDenominatorCohortSet()

Create a basic denominator population

cdm <- IncidencePrevalence::mockIncidencePrevalence(sampleSize = 50000)

cdm <- generateDenominatorCohortSet(cdm, name = "dpop")

cdm$dpop %>%
  glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [dnewby@Windows 10 x64:R 4.2.3/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1…
$ subject_id           <int> 1, 3, 7, 11, 14, 21, 29, 32, 33, 36, 37, 41, 42, …
$ cohort_start_date    <date> 1949-10-29, 1977-03-02, 1994-07-10, 1945-08-21, …
$ cohort_end_date      <date> 1957-03-20, 1982-06-05, 1996-11-16, 1951-02-11, …

generateDenominatorCohortSet()

Add a study period

cdm <- generateDenominatorCohortSet(
  cdm = cdm, 
  name = "dpop",
  cohortDateRange = as.Date(c("2008-01-01", "2012-01-01"))
)

cdm$dpop %>%
  glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [dnewby@Windows 10 x64:R 4.2.3/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1…
$ subject_id           <int> 33, 41, 52, 59, 69, 76, 79, 89, 122, 141, 151, 16…
$ cohort_start_date    <date> 2008-01-01, 2008-01-01, 2008-01-01, 2008-01-01, …
$ cohort_end_date      <date> 2008-08-04, 2012-01-01, 2011-10-24, 2012-01-01, …

generateDenominatorCohortSet()

Look at the n in the denominator

cohortCount(cdm$dpop)
# A tibble: 1 × 3
  cohort_definition_id number_records number_subjects
                 <int>          <int>           <int>
1                    1           3575            3575

Look at the settings you used for denominator

settings(cdm$dpop)
# A tibble: 1 × 11
  cohort_definition_id cohort_name        age_group sex   days_prior_observation
                 <int> <chr>              <chr>     <chr>                  <dbl>
1                    1 denominator_cohor… 0 to 150  Both                       0
# ℹ 6 more variables: start_date <date>, end_date <date>,
#   requirements_at_entry <chr>, target_cohort_definition_id <int>,
#   target_cohort_name <chr>, time_at_risk <chr>

generateDenominatorCohortSet()

How did you get the denominator population?

attrition(cdm$dpop)
# A tibble: 8 × 7
  cohort_definition_id number_records number_subjects reason_id reason          
                 <int>          <int>           <int>     <int> <chr>           
1                    1          50000           50000         1 Starting popula…
2                    1          50000           50000         2 Missing year of…
3                    1          50000           50000         3 Missing sex     
4                    1          50000           50000         4 Cannot satisfy …
5                    1           3575            3575         5 No observation …
6                    1           3575            3575         6 Doesn't satisfy…
7                    1           3575            3575         7 Prior history r…
8                    1           3575            3575        10 No observation …
# ℹ 2 more variables: excluded_records <int>, excluded_subjects <int>

generateDenominatorCohortSet()

Adding in more stratification of denominator

cdm <- generateDenominatorCohortSet(
  cdm = cdm, 
  name = "dpop",
  cohortDateRange = as.Date(c("2008-01-01", "2012-01-01")),
  ageGroup = list(
    c(0, 49),
    c(50, 100)
  ),
  sex = c("Male", "Female"),
  daysPriorObservation= c(0, 180)
)

cdm$dpop %>%
  glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [dnewby@Windows 10 x64:R 4.2.3/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1…
$ subject_id           <int> 59, 89, 200, 208, 396, 501, 579, 581, 615, 642, 6…
$ cohort_start_date    <date> 2008-01-01, 2008-01-01, 2008-01-01, 2008-01-01, …
$ cohort_end_date      <date> 2012-01-01, 2009-08-06, 2010-12-23, 2012-01-01, …

generateDenominatorCohortSet()

Have a look at the settings again

settings(cdm$dpop)
# A tibble: 8 × 11
  cohort_definition_id cohort_name        age_group sex   days_prior_observation
                 <int> <chr>              <chr>     <chr>                  <dbl>
1                    1 denominator_cohor… 0 to 49   Male                       0
2                    2 denominator_cohor… 0 to 49   Male                     180
3                    3 denominator_cohor… 0 to 49   Fema…                      0
4                    4 denominator_cohor… 0 to 49   Fema…                    180
5                    5 denominator_cohor… 50 to 100 Male                       0
6                    6 denominator_cohor… 50 to 100 Male                     180
7                    7 denominator_cohor… 50 to 100 Fema…                      0
8                    8 denominator_cohor… 50 to 100 Fema…                    180
# ℹ 6 more variables: start_date <date>, end_date <date>,
#   requirements_at_entry <chr>, target_cohort_definition_id <int>,
#   target_cohort_name <chr>, time_at_risk <chr>

generateDenominatorCohortSet()

Have a look at the counts

cohortCount(cdm$dpop)
# A tibble: 8 × 3
  cohort_definition_id number_records number_subjects
                 <int>          <int>           <int>
1                    1            973             973
2                    2            959             959
3                    3            902             902
4                    4            890             890
5                    5            933             933
6                    6            925             925
7                    7            922             922
8                    8            900             900

Adding time-invariant variables for stratification

If we want to stratify for some time-invariant variable e.g region, ethnicity, we need to add this variable to our denominator.

cdm$dpop <- cdm$dpop %>% 
  mutate(group = if_else(as.numeric(subject_id) < 20, "first", "second")) 

cdm$dpop |> 
  glimpse()
Rows: ??
Columns: 5
Database: DuckDB v1.0.0 [dnewby@Windows 10 x64:R 4.2.3/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1…
$ subject_id           <int> 59, 89, 200, 208, 396, 501, 579, 581, 615, 642, 6…
$ cohort_start_date    <date> 2008-01-01, 2008-01-01, 2008-01-01, 2008-01-01, …
$ cohort_end_date      <date> 2012-01-01, 2009-08-06, 2010-12-23, 2012-01-01, …
$ group                <chr> "second", "second", "second", "second", "second",…

generateTargetDenominatorCohortSet()

When we want to stratify on a time-varying variable, we can do this by creating a cohort for it. Once we have the cohort we will will use it when creating our denominator cohort.

generateTargetDenominatorCohortSet()

Code to create a target denominator

personTable <- tibble(
  person_id = c("1", "2", "3", "4", "5"),
  gender_concept_id = c(rep("8507", 2), rep("8532", 3)),
  year_of_birth = 2000,
  month_of_birth = 06,
  day_of_birth = 01
)
observationPeriodTable <- tibble(
  observation_period_id = "1",
  person_id = c("1", "2", "3", "4", "5"),
  observation_period_start_date = c(
    as.Date("2010-12-19"),
    as.Date("2005-04-01"),
    as.Date("2009-04-10"),
    as.Date("2010-08-20"),
    as.Date("2010-01-01")
  ),
  observation_period_end_date = c(
    as.Date("2011-06-19"),
    as.Date("2005-11-29"),
    as.Date("2016-01-02"),
    as.Date("2011-12-11"),
    as.Date("2015-06-01")
  )
)

acute_asthma <- tibble(
  cohort_definition_id = rep("1", 5),
  subject_id = c("3", "3", "5", "5", "2"),
  cohort_start_date = c(
    as.Date("2012-01-01"),
    as.Date("2015-06-01"),
    as.Date("2014-10-01"),
    as.Date("2010-06-01"),
    as.Date("2005-08-20")
  ),
  cohort_end_date = c(
    as.Date("2013-01-01"),
    as.Date("2015-12-31"),
    as.Date("2015-04-01"),
    as.Date("2010-06-01"),
    as.Date("2005-09-20")
  )
)

# mock database
cdm <- IncidencePrevalence::mockIncidencePrevalence(
  personTable = personTable,
  observationPeriodTable = observationPeriodTable,
  targetCohortTable = acute_asthma
)

generateTargetDenominatorCohortSet()

Then we can create the target denominator cohort for just acute asthma patients

cdm <- generateTargetDenominatorCohortSet(
  cdm = cdm, 
  name = "denominator_acute_asthma",
  targetCohortTable = "target"
)

cdm$denominator_acute_asthma |> 
  dplyr::glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [dnewby@Windows 10 x64:R 4.2.3/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1
$ subject_id           <chr> "3", "3", "5", "5", "2"
$ cohort_start_date    <date> 2012-01-01, 2015-06-01, 2014-10-01, 2010-06-01, 2…
$ cohort_end_date      <date> 2013-01-01, 2015-12-31, 2015-04-01, 2010-06-01, 2…

generateTargetDenominatorCohortSet()

  • We can add demographic requirements like before.
  • Note these are applied at the cohort start date of target cohort as default.
  • You can change this but needs careful thought on why and impact.
cdm <- generateTargetDenominatorCohortSet(
  cdm = cdm, 
  name = "denominator_acute_asthma_2",
  ageGroup = list(c(11, 15)),
  sex = "Female",
  daysPriorObservation = 0,
  targetCohortTable = "target",
  requirementsAtEntry = TRUE
)
cdm$denominator_acute_asthma_2 |> 
  dplyr::glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [dnewby@Windows 10 x64:R 4.2.3/:memory:]
$ cohort_definition_id <int> 1, 1, 1
$ subject_id           <chr> "3", "3", "5"
$ cohort_start_date    <date> 2012-01-01, 2015-06-01, 2014-10-01
$ cohort_end_date      <date> 2013-01-01, 2015-12-31, 2015-04-01

estimateIncidence()

Generate our denominator then estimate yearly incidence with infinite outcome washout.

cdm <- IncidencePrevalence::mockIncidencePrevalence(
  sampleSize = 50000,
  outPre = 0.5
)

cdm <- generateDenominatorCohortSet(
  cdm = cdm, 
  name = "denominator",
  cohortDateRange = as.Date(c("2008-01-01", "2012-01-01")),
  ageGroup = list(
    c(0, 30),
    c(31, 50),
    c(51, 70),
    c(71, 100)
  )
)
inc <- estimateIncidence(
  cdm = cdm,
  denominatorTable = "denominator",
  outcomeTable = "outcome",
  interval = "years",
  outcomeWashout = Inf,
  repeatedEvents = FALSE
)

estimateIncidence()

inc %>%
  glimpse()
Rows: 288
Columns: 13
$ result_id        <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
$ cdm_name         <chr> "mock", "mock", "mock", "mock", "mock", "mock", "mock…
$ group_name       <chr> "denominator_cohort_name &&& outcome_cohort_name", "d…
$ group_level      <chr> "denominator_cohort_1 &&& cohort_1", "denominator_coh…
$ strata_name      <chr> "overall", "overall", "overall", "overall", "overall"…
$ strata_level     <chr> "overall", "overall", "overall", "overall", "overall"…
$ variable_name    <chr> "Denominator", "Outcome", "Denominator", "Denominator…
$ variable_level   <chr> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…
$ estimate_name    <chr> "denominator_count", "outcome_count", "person_days", …
$ estimate_type    <chr> "integer", "integer", "numeric", "numeric", "numeric"…
$ estimate_value   <chr> "662", "63", "189075", "517.659", "12170.174", "9351.…
$ additional_name  <chr> "incidence_start_date &&& incidence_end_date &&& anal…
$ additional_level <chr> "2008-01-01 &&& 2008-12-31 &&& years", "2008-01-01 &&…

estimateIncidence()

Generate our denominator then estimate monthly incidence with 0 and 365 outcome washout

inc <- estimateIncidence(
  cdm = cdm,
  denominatorTable = "denominator",
  outcomeTable = "outcome",
  interval = c("Months"),
  outcomeWashout = c(0, 365),
  repeatedEvents = FALSE
)
inc %>%
  glimpse()
Rows: 3,040
Columns: 13
$ result_id        <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
$ cdm_name         <chr> "mock", "mock", "mock", "mock", "mock", "mock", "mock…
$ group_name       <chr> "denominator_cohort_name &&& outcome_cohort_name", "d…
$ group_level      <chr> "denominator_cohort_1 &&& cohort_1", "denominator_coh…
$ strata_name      <chr> "overall", "overall", "overall", "overall", "overall"…
$ strata_level     <chr> "overall", "overall", "overall", "overall", "overall"…
$ variable_name    <chr> "Denominator", "Outcome", "Denominator", "Denominator…
$ variable_level   <chr> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…
$ estimate_name    <chr> "denominator_count", "outcome_count", "person_days", …
$ estimate_type    <chr> "integer", "integer", "numeric", "numeric", "numeric"…
$ estimate_value   <chr> "766", "3", "23332", "63.88", "4696.306", "968.491", …
$ additional_name  <chr> "incidence_start_date &&& incidence_end_date &&& anal…
$ additional_level <chr> "2008-01-01 &&& 2008-01-31 &&& months", "2008-01-01 &…

estimateIncidence()

We can plot the results with one argument!

plot <- plotIncidence(inc,
              facet = "denominator_age_group")

estimateIncidence()

Pretty plot but you can make it better by changing settings.

plot

estimateIncidence()

We can make a nice table of the incidence results.

Denominator cohort name Variable name Incidence start date Incidence end date Denominator age group Denominator sex Analysis outcome washout Estimate name
Denominator (N) Person-years Outcome (N) Incidence 100,000 person-years [95% CI]
mock; cohort_1
denominator_cohort_1 Denominator 2008-01-01 2008-01-31 0 to 30 Both 0 766 63.88 - -
Outcome 2008-01-01 2008-01-31 0 to 30 Both 0 - - 3 4,696.31 (968.49 - 13,724.60)
Denominator 2008-02-01 2008-02-29 0 to 30 Both 0 761 59.27 - -
Outcome 2008-02-01 2008-02-29 0 to 30 Both 0 - - 3 5,061.41 (1,043.79 - 14,791.59)
Denominator 2008-03-01 2008-03-31 0 to 30 Both 0 758 62.81 - -
Outcome 2008-03-01 2008-03-31 0 to 30 Both 0 - - 7 11,144.90 (4,480.83 - 22,962.75)
Denominator 2008-04-01 2008-04-30 0 to 30 Both 0 742 59.32 - -
Outcome 2008-04-01 2008-04-30 0 to 30 Both 0 - - 7 11,800.21 (4,744.30 - 24,312.93)
Denominator 2008-05-01 2008-05-31 0 to 30 Both 0 723 60.78 - -
Outcome 2008-05-01 2008-05-31 0 to 30 Both 0 - - 3 4,935.83 (1,017.89 - 14,424.60)
Denominator 2008-06-01 2008-06-30 0 to 30 Both 0 718 57.90 - -
Outcome 2008-06-01 2008-06-30 0 to 30 Both 0 - - 7 12,089.18 (4,860.48 - 24,908.34)
Denominator 2008-07-01 2008-07-31 0 to 30 Both 0 706 59.01 - -
Outcome 2008-07-01 2008-07-31 0 to 30 Both 0 - - 4 6,778.05 (1,846.79 - 17,354.51)
Denominator 2008-08-01 2008-08-31 0 to 30 Both 0 706 58.66 - -
Outcome 2008-08-01 2008-08-31 0 to 30 Both 0 - - 6 10,228.78 (3,753.78 - 22,263.76)
Denominator 2008-09-01 2008-09-30 0 to 30 Both 0 695 56.20 - -
Outcome 2008-09-01 2008-09-30 0 to 30 Both 0 - - 8 14,234.12 (6,145.28 - 28,046.88)
Denominator 2008-10-01 2008-10-31 0 to 30 Both 0 690 57.10 - -
Outcome 2008-10-01 2008-10-31 0 to 30 Both 0 - - 3 5,253.66 (1,083.43 - 15,353.44)
Denominator 2008-11-01 2008-11-30 0 to 30 Both 0 679 54.41 - -
Outcome 2008-11-01 2008-11-30 0 to 30 Both 0 - - 4 7,351.73 (2,003.10 - 18,823.34)
Denominator 2008-12-01 2008-12-31 0 to 30 Both 0 678 56.12 - -
Outcome 2008-12-01 2008-12-31 0 to 30 Both 0 - - 8 14,255.17 (6,154.37 - 28,088.36)
Denominator 2009-01-01 2009-01-31 0 to 30 Both 0 668 55.59 - -
Outcome 2009-01-01 2009-01-31 0 to 30 Both 0 - - 7 12,592.42 (5,062.81 - 25,945.20)
Denominator 2009-02-01 2009-02-28 0 to 30 Both 0 656 49.40 - -
Outcome 2009-02-01 2009-02-28 0 to 30 Both 0 - - 6 12,146.73 (4,457.64 - 26,438.32)
Denominator 2009-03-01 2009-03-31 0 to 30 Both 0 648 54.18 - -
Outcome 2009-03-01 2009-03-31 0 to 30 Both 0 - - 2 3,691.60 (447.07 - 13,335.34)
Denominator 2009-04-01 2009-04-30 0 to 30 Both 0 649 52.01 - -
Outcome 2009-04-01 2009-04-30 0 to 30 Both 0 - - 7 13,458.69 (5,411.09 - 27,730.05)
Denominator 2009-05-01 2009-05-31 0 to 30 Both 0 645 52.99 - -
Outcome 2009-05-01 2009-05-31 0 to 30 Both 0 - - 9 16,983.06 (7,765.73 - 32,239.13)
Denominator 2009-06-01 2009-06-30 0 to 30 Both 0 631 50.56 - -
Outcome 2009-06-01 2009-06-30 0 to 30 Both 0 - - 6 11,867.79 (4,355.27 - 25,831.19)
Denominator 2009-07-01 2009-07-31 0 to 30 Both 0 616 51.49 - -
Outcome 2009-07-01 2009-07-31 0 to 30 Both 0 - - 6 11,652.07 (4,276.10 - 25,361.65)
Denominator 2009-08-01 2009-08-31 0 to 30 Both 0 614 50.94 - -
Outcome 2009-08-01 2009-08-31 0 to 30 Both 0 - - 4 7,853.15 (2,139.72 - 20,107.17)
Denominator 2009-09-01 2009-09-30 0 to 30 Both 0 612 49.27 - -
Outcome 2009-09-01 2009-09-30 0 to 30 Both 0 - - 5 10,148.16 (3,295.08 - 23,682.43)
Denominator 2009-10-01 2009-10-31 0 to 30 Both 0 604 50.52 - -
Outcome 2009-10-01 2009-10-31 0 to 30 Both 0 - - 4 7,918.28 (2,157.47 - 20,273.95)
Denominator 2009-11-01 2009-11-30 0 to 30 Both 0 603 48.83 - -
Outcome 2009-11-01 2009-11-30 0 to 30 Both 0 - - 4 8,192.19 (2,232.10 - 20,975.26)
Denominator 2009-12-01 2009-12-31 0 to 30 Both 0 599 49.83 - -
Outcome 2009-12-01 2009-12-31 0 to 30 Both 0 - - 4 8,027.94 (2,187.34 - 20,554.71)
Denominator 2010-01-01 2010-01-31 0 to 30 Both 0 580 48.64 - -
Outcome 2010-01-01 2010-01-31 0 to 30 Both 0 - - 4 8,223.18 (2,240.54 - 21,054.60)
Denominator 2010-02-01 2010-02-28 0 to 30 Both 0 566 43.01 - -
Outcome 2010-02-01 2010-02-28 0 to 30 Both 0 - - 5 11,625.47 (3,774.76 - 27,129.98)
Denominator 2010-03-01 2010-03-31 0 to 30 Both 0 554 46.37 - -
Outcome 2010-03-01 2010-03-31 0 to 30 Both 0 - - 5 10,782.60 (3,501.08 - 25,162.99)
Denominator 2010-04-01 2010-04-30 0 to 30 Both 0 539 43.83 - -
Outcome 2010-04-01 2010-04-30 0 to 30 Both 0 - - 3 6,844.63 (1,411.53 - 20,002.90)
Denominator 2010-05-01 2010-05-31 0 to 30 Both 0 528 44.40 - -
Outcome 2010-05-01 2010-05-31 0 to 30 Both 0 - - 4 9,009.62 (2,454.82 - 23,068.20)
Denominator 2010-06-01 2010-06-30 0 to 30 Both 0 514 41.66 - -
Outcome 2010-06-01 2010-06-30 0 to 30 Both 0 - - 3 7,200.81 (1,484.98 - 21,043.81)
Denominator 2010-07-01 2010-07-31 0 to 30 Both 0 501 42.03 - -
Outcome 2010-07-01 2010-07-31 0 to 30 Both 0 - - 6 14,275.86 (5,238.99 - 31,072.53)
Denominator 2010-08-01 2010-08-31 0 to 30 Both 0 489 40.84 - -
Outcome 2010-08-01 2010-08-31 0 to 30 Both 0 - - 5 12,242.00 (3,974.94 - 28,568.74)
Denominator 2010-09-01 2010-09-30 0 to 30 Both 0 473 38.30 - -
Outcome 2010-09-01 2010-09-30 0 to 30 Both 0 - - 5 13,053.13 (4,238.31 - 30,461.64)
Denominator 2010-10-01 2010-10-31 0 to 30 Both 0 458 38.32 - -
Outcome 2010-10-01 2010-10-31 0 to 30 Both 0 - - 3 7,827.99 (1,614.32 - 22,876.72)
Denominator 2010-11-01 2010-11-30 0 to 30 Both 0 444 36.06 - -
Outcome 2010-11-01 2010-11-30 0 to 30 Both 0 - - 1 2,773.16 (70.21 - 15,451.03)
Denominator 2010-12-01 2010-12-31 0 to 30 Both 0 435 36.26 - -
Outcome 2010-12-01 2010-12-31 0 to 30 Both 0 - - 5 13,789.30 (4,477.35 - 32,179.62)
Denominator 2011-01-01 2011-01-31 0 to 30 Both 0 421 35.18 - -
Outcome 2011-01-01 2011-01-31 0 to 30 Both 0 - - 2 5,684.89 (688.47 - 20,535.77)
Denominator 2011-02-01 2011-02-28 0 to 30 Both 0 410 31.40 - -
Outcome 2011-02-01 2011-02-28 0 to 30 Both 0 - - 1 3,185.22 (80.64 - 17,746.91)
Denominator 2011-03-01 2011-03-31 0 to 30 Both 0 408 34.07 - -
Outcome 2011-03-01 2011-03-31 0 to 30 Both 0 - - 5 14,675.67 (4,765.15 - 34,248.11)
Denominator 2011-04-01 2011-04-30 0 to 30 Both 0 392 32.02 - -
Outcome 2011-04-01 2011-04-30 0 to 30 Both 0 - - 1 3,123.15 (79.07 - 17,401.05)
Denominator 2011-05-01 2011-05-31 0 to 30 Both 0 383 32.02 - -
Outcome 2011-05-01 2011-05-31 0 to 30 Both 0 - - 2 6,245.71 (756.38 - 22,561.64)
Denominator 2011-06-01 2011-06-30 0 to 30 Both 0 373 30.42 - -
Outcome 2011-06-01 2011-06-30 0 to 30 Both 0 - - 1 3,286.99 (83.22 - 18,313.92)
Denominator 2011-07-01 2011-07-31 0 to 30 Both 0 368 30.69 - -
Outcome 2011-07-01 2011-07-31 0 to 30 Both 0 - - 1 3,258.82 (82.51 - 18,156.96)
Denominator 2011-08-01 2011-08-31 0 to 30 Both 0 355 29.81 - -
Outcome 2011-08-01 2011-08-31 0 to 30 Both 0 - - 1 3,354.35 (84.92 - 18,689.26)
Denominator 2011-09-01 2011-09-30 0 to 30 Both 0 348 28.04 - -
Outcome 2011-09-01 2011-09-30 0 to 30 Both 0 - - 4 14,267.37 (3,887.38 - 36,530.14)
Denominator 2011-10-01 2011-10-31 0 to 30 Both 0 336 28.09 - -
Outcome 2011-10-01 2011-10-31 0 to 30 Both 0 - - 2 7,119.21 (862.17 - 25,717.04)
Denominator 2011-11-01 2011-11-30 0 to 30 Both 0 326 26.19 - -
Outcome 2011-11-01 2011-11-30 0 to 30 Both 0 - - 2 7,635.63 (924.71 - 27,582.51)
Denominator 2011-12-01 2011-12-31 0 to 30 Both 0 314 26.37 - -
Outcome 2011-12-01 2011-12-31 0 to 30 Both 0 - - 4 15,168.18 (4,132.82 - 38,836.56)
denominator_cohort_2 Denominator 2008-01-01 2008-01-31 31 to 50 Both 0 713 59.08 - -
Outcome 2008-01-01 2008-01-31 31 to 50 Both 0 - - 4 6,771.05 (1,844.88 - 17,336.59)
Denominator 2008-02-01 2008-02-29 31 to 50 Both 0 707 55.32 - -
Outcome 2008-02-01 2008-02-29 31 to 50 Both 0 - - 3 5,423.39 (1,118.43 - 15,849.43)
Denominator 2008-03-01 2008-03-31 31 to 50 Both 0 708 58.98 - -
Outcome 2008-03-01 2008-03-31 31 to 50 Both 0 - - 6 10,173.11 (3,733.35 - 22,142.58)
Denominator 2008-04-01 2008-04-30 31 to 50 Both 0 705 57.17 - -
Outcome 2008-04-01 2008-04-30 31 to 50 Both 0 - - 2 3,498.22 (423.65 - 12,636.76)
Denominator 2008-05-01 2008-05-31 31 to 50 Both 0 703 58.94 - -
Outcome 2008-05-01 2008-05-31 31 to 50 Both 0 - - 2 3,393.57 (410.98 - 12,258.74)
Denominator 2008-06-01 2008-06-30 31 to 50 Both 0 706 56.85 - -
Outcome 2008-06-01 2008-06-30 31 to 50 Both 0 - - 6 10,554.27 (3,873.23 - 22,972.21)
Denominator 2008-07-01 2008-07-31 31 to 50 Both 0 707 58.83 - -
Outcome 2008-07-01 2008-07-31 31 to 50 Both 0 - - 3 5,099.61 (1,051.66 - 14,903.23)
Denominator 2008-08-01 2008-08-31 31 to 50 Both 0 702 58.58 - -
Outcome 2008-08-01 2008-08-31 31 to 50 Both 0 - - 3 5,121.03 (1,056.08 - 14,965.81)
Denominator 2008-09-01 2008-09-30 31 to 50 Both 0 694 55.85 - -
Outcome 2008-09-01 2008-09-30 31 to 50 Both 0 - - 8 14,324.85 (6,184.45 - 28,225.67)
Denominator 2008-10-01 2008-10-31 31 to 50 Both 0 684 56.47 - -
Outcome 2008-10-01 2008-10-31 31 to 50 Both 0 - - 3 5,312.46 (1,095.56 - 15,525.27)
Denominator 2008-11-01 2008-11-30 31 to 50 Both 0 665 53.90 - -
Outcome 2008-11-01 2008-11-30 31 to 50 Both 0 - - 3 5,565.55 (1,147.75 - 16,264.91)
Denominator 2008-12-01 2008-12-31 31 to 50 Both 0 660 54.59 - -
Outcome 2008-12-01 2008-12-31 31 to 50 Both 0 - - 7 12,823.57 (5,155.74 - 26,421.45)
Denominator 2009-01-01 2009-01-31 31 to 50 Both 0 660 54.50 - -
Outcome 2009-01-01 2009-01-31 31 to 50 Both 0 - - 4 7,339.85 (1,999.86 - 18,792.94)
Denominator 2009-02-01 2009-02-28 31 to 50 Both 0 652 49.14 - -
Outcome 2009-02-01 2009-02-28 31 to 50 Both 0 - - 3 6,105.13 (1,259.03 - 17,841.78)
Denominator 2009-03-01 2009-03-31 31 to 50 Both 0 648 54.20 - -
Outcome 2009-03-01 2009-03-31 31 to 50 Both 0 - - 3 5,535.46 (1,141.55 - 16,176.97)
Denominator 2009-04-01 2009-04-30 31 to 50 Both 0 645 51.95 - -
Outcome 2009-04-01 2009-04-30 31 to 50 Both 0 - - 5 9,624.45 (3,125.03 - 22,460.26)
Denominator 2009-05-01 2009-05-31 31 to 50 Both 0 643 53.76 - -
Outcome 2009-05-01 2009-05-31 31 to 50 Both 0 - - 3 5,580.36 (1,150.80 - 16,308.17)
Denominator 2009-06-01 2009-06-30 31 to 50 Both 0 652 52.17 - -
Outcome 2009-06-01 2009-06-30 31 to 50 Both 0 - - 4 7,666.51 (2,088.86 - 19,629.30)
Denominator 2009-07-01 2009-07-31 31 to 50 Both 0 654 54.36 - -
Outcome 2009-07-01 2009-07-31 31 to 50 Both 0 - - 5 9,198.45 (2,986.71 - 21,466.11)
Denominator 2009-08-01 2009-08-31 31 to 50 Both 0 653 54.20 - -
Outcome 2009-08-01 2009-08-31 31 to 50 Both 0 - - 9 16,605.78 (7,593.22 - 31,522.94)
Denominator 2009-09-01 2009-09-30 31 to 50 Both 0 647 52.11 - -
Outcome 2009-09-01 2009-09-30 31 to 50 Both 0 - - 4 7,676.51 (2,091.59 - 19,654.92)
Denominator 2009-10-01 2009-10-31 31 to 50 Both 0 645 53.50 - -
Outcome 2009-10-01 2009-10-31 31 to 50 Both 0 - - 7 13,084.11 (5,260.49 - 26,958.27)
Denominator 2009-11-01 2009-11-30 31 to 50 Both 0 629 50.71 - -
Outcome 2009-11-01 2009-11-30 31 to 50 Both 0 - - 5 9,859.99 (3,201.51 - 23,009.92)
Denominator 2009-12-01 2009-12-31 31 to 50 Both 0 632 52.01 - -
Outcome 2009-12-01 2009-12-31 31 to 50 Both 0 - - 4 7,690.24 (2,095.33 - 19,690.06)
Denominator 2010-01-01 2010-01-31 31 to 50 Both 0 620 51.95 - -
Outcome 2010-01-01 2010-01-31 31 to 50 Both 0 - - 6 11,550.01 (4,238.65 - 25,139.51)
Denominator 2010-02-01 2010-02-28 31 to 50 Both 0 607 46.00 - -
Outcome 2010-02-01 2010-02-28 31 to 50 Both 0 - - 7 15,217.72 (6,118.31 - 31,354.32)
Denominator 2010-03-01 2010-03-31 31 to 50 Both 0 591 49.31 - -
Outcome 2010-03-01 2010-03-31 31 to 50 Both 0 - - 6 12,168.16 (4,465.50 - 26,484.97)
Denominator 2010-04-01 2010-04-30 31 to 50 Both 0 575 46.77 - -
Outcome 2010-04-01 2010-04-30 31 to 50 Both 0 - - 1 2,138.08 (54.13 - 11,912.60)
Denominator 2010-05-01 2010-05-31 31 to 50 Both 0 566 46.95 - -
Outcome 2010-05-01 2010-05-31 31 to 50 Both 0 - - 4 8,520.43 (2,321.53 - 21,815.68)
Denominator 2010-06-01 2010-06-30 31 to 50 Both 0 547 44.55 - -
Outcome 2010-06-01 2010-06-30 31 to 50 Both 0 - - 1 2,244.52 (56.83 - 12,505.65)
Denominator 2010-07-01 2010-07-31 31 to 50 Both 0 538 45.03 - -
Outcome 2010-07-01 2010-07-31 31 to 50 Both 0 - - 6 13,322.97 (4,889.30 - 28,998.50)
Denominator 2010-08-01 2010-08-31 31 to 50 Both 0 527 44.20 - -
Outcome 2010-08-01 2010-08-31 31 to 50 Both 0 - - 5 11,312.99 (3,673.30 - 26,400.73)
Denominator 2010-09-01 2010-09-30 31 to 50 Both 0 516 42.04 - -
Outcome 2010-09-01 2010-09-30 31 to 50 Both 0 - - 3 7,135.72 (1,471.56 - 20,853.61)
Denominator 2010-10-01 2010-10-31 31 to 50 Both 0 507 42.04 - -
Outcome 2010-10-01 2010-10-31 31 to 50 Both 0 - - 2 4,757.37 (576.14 - 17,185.27)
Denominator 2010-11-01 2010-11-30 31 to 50 Both 0 491 39.77 - -
Outcome 2010-11-01 2010-11-30 31 to 50 Both 0 - - 4 10,057.83 (2,740.42 - 25,752.05)
Denominator 2010-12-01 2010-12-31 31 to 50 Both 0 482 40.22 - -
Outcome 2010-12-01 2010-12-31 31 to 50 Both 0 - - 3 7,458.60 (1,538.14 - 21,797.21)
Denominator 2011-01-01 2011-01-31 31 to 50 Both 0 470 39.17 - -
Outcome 2011-01-01 2011-01-31 31 to 50 Both 0 - - 4 10,211.11 (2,782.18 - 26,144.51)
Denominator 2011-02-01 2011-02-28 31 to 50 Both 0 458 34.62 - -
Outcome 2011-02-01 2011-02-28 31 to 50 Both 0 - - 2 5,777.84 (699.72 - 20,871.55)
Denominator 2011-03-01 2011-03-31 31 to 50 Both 0 446 37.56 - -
Outcome 2011-03-01 2011-03-31 31 to 50 Both 0 - - 1 2,662.19 (67.40 - 14,832.80)
Denominator 2011-04-01 2011-04-30 31 to 50 Both 0 442 36.13 - -
Outcome 2011-04-01 2011-04-30 31 to 50 Both 0 - - 0 0.00 (0.00 - 10,208.89)
Denominator 2011-05-01 2011-05-31 31 to 50 Both 0 441 36.80 - -
Outcome 2011-05-01 2011-05-31 31 to 50 Both 0 - - 4 10,868.98 (2,961.43 - 27,828.89)
Denominator 2011-06-01 2011-06-30 31 to 50 Both 0 431 34.79 - -
Outcome 2011-06-01 2011-06-30 31 to 50 Both 0 - - 5 14,373.18 (4,666.93 - 33,542.22)
Denominator 2011-07-01 2011-07-31 31 to 50 Both 0 420 35.09 - -
Outcome 2011-07-01 2011-07-31 31 to 50 Both 0 - - 3 8,548.47 (1,762.90 - 24,982.26)
Denominator 2011-08-01 2011-08-31 31 to 50 Both 0 408 34.00 - -
Outcome 2011-08-01 2011-08-31 31 to 50 Both 0 - - 5 14,705.45 (4,774.82 - 34,317.61)
Denominator 2011-09-01 2011-09-30 31 to 50 Both 0 397 32.08 - -
Outcome 2011-09-01 2011-09-30 31 to 50 Both 0 - - 3 9,351.91 (1,928.59 - 27,330.26)
Denominator 2011-10-01 2011-10-31 31 to 50 Both 0 388 32.36 - -
Outcome 2011-10-01 2011-10-31 31 to 50 Both 0 - - 1 3,089.85 (78.23 - 17,215.56)
Denominator 2011-11-01 2011-11-30 31 to 50 Both 0 379 30.45 - -
Outcome 2011-11-01 2011-11-30 31 to 50 Both 0 - - 4 13,136.29 (3,579.20 - 33,634.12)
Denominator 2011-12-01 2011-12-31 31 to 50 Both 0 366 30.78 - -
Outcome 2011-12-01 2011-12-31 31 to 50 Both 0 - - 1 3,248.65 (82.25 - 18,100.33)
denominator_cohort_3 Denominator 2008-01-01 2008-01-31 51 to 70 Both 0 669 55.44 - -
Outcome 2008-01-01 2008-01-31 51 to 70 Both 0 - - 5 9,018.60 (2,928.31 - 21,046.40)
Denominator 2008-02-01 2008-02-29 51 to 70 Both 0 664 51.73 - -
Outcome 2008-02-01 2008-02-29 51 to 70 Both 0 - - 6 11,598.24 (4,256.35 - 25,244.48)
Denominator 2008-03-01 2008-03-31 51 to 70 Both 0 659 54.30 - -
Outcome 2008-03-01 2008-03-31 51 to 70 Both 0 - - 1 1,841.52 (46.62 - 10,260.29)
Denominator 2008-04-01 2008-04-30 51 to 70 Both 0 650 51.93 - -
Outcome 2008-04-01 2008-04-30 51 to 70 Both 0 - - 7 13,480.72 (5,419.95 - 27,775.44)
Denominator 2008-05-01 2008-05-31 51 to 70 Both 0 638 53.08 - -
Outcome 2008-05-01 2008-05-31 51 to 70 Both 0 - - 6 11,304.54 (4,148.57 - 24,605.23)
Denominator 2008-06-01 2008-06-30 51 to 70 Both 0 635 51.47 - -
Outcome 2008-06-01 2008-06-30 51 to 70 Both 0 - - 5 9,713.64 (3,153.99 - 22,668.40)
Denominator 2008-07-01 2008-07-31 51 to 70 Both 0 641 53.26 - -
Outcome 2008-07-01 2008-07-31 51 to 70 Both 0 - - 7 13,142.58 (5,284.00 - 27,078.73)
Denominator 2008-08-01 2008-08-31 51 to 70 Both 0 642 53.04 - -
Outcome 2008-08-01 2008-08-31 51 to 70 Both 0 - - 5 9,427.20 (3,060.99 - 21,999.95)
Denominator 2008-09-01 2008-09-30 51 to 70 Both 0 631 50.72 - -
Outcome 2008-09-01 2008-09-30 51 to 70 Both 0 - - 3 5,914.71 (1,219.76 - 17,285.29)
Denominator 2008-10-01 2008-10-31 51 to 70 Both 0 625 52.53 - -
Outcome 2008-10-01 2008-10-31 51 to 70 Both 0 - - 4 7,614.55 (2,074.71 - 19,496.28)
Denominator 2008-11-01 2008-11-30 51 to 70 Both 0 632 50.85 - -
Outcome 2008-11-01 2008-11-30 51 to 70 Both 0 - - 1 1,966.57 (49.79 - 10,957.02)
Denominator 2008-12-01 2008-12-31 51 to 70 Both 0 626 52.23 - -
Outcome 2008-12-01 2008-12-31 51 to 70 Both 0 - - 6 11,486.99 (4,215.52 - 25,002.34)
Denominator 2009-01-01 2009-01-31 51 to 70 Both 0 627 52.12 - -
Outcome 2009-01-01 2009-01-31 51 to 70 Both 0 - - 4 7,674.89 (2,091.15 - 19,650.77)
Denominator 2009-02-01 2009-02-28 51 to 70 Both 0 630 47.51 - -
Outcome 2009-02-01 2009-02-28 51 to 70 Both 0 - - 1 2,104.82 (53.29 - 11,727.31)
Denominator 2009-03-01 2009-03-31 51 to 70 Both 0 629 51.82 - -
Outcome 2009-03-01 2009-03-31 51 to 70 Both 0 - - 10 19,297.94 (9,254.11 - 35,489.60)
Denominator 2009-04-01 2009-04-30 51 to 70 Both 0 617 49.66 - -
Outcome 2009-04-01 2009-04-30 51 to 70 Both 0 - - 7 14,096.14 (5,667.38 - 29,043.43)
Denominator 2009-05-01 2009-05-31 51 to 70 Both 0 622 51.48 - -
Outcome 2009-05-01 2009-05-31 51 to 70 Both 0 - - 3 5,827.84 (1,201.84 - 17,031.44)
Denominator 2009-06-01 2009-06-30 51 to 70 Both 0 618 49.93 - -
Outcome 2009-06-01 2009-06-30 51 to 70 Both 0 - - 6 12,016.82 (4,409.96 - 26,155.57)
Denominator 2009-07-01 2009-07-31 51 to 70 Both 0 618 51.09 - -
Outcome 2009-07-01 2009-07-31 51 to 70 Both 0 - - 8 15,657.42 (6,759.76 - 30,851.35)
Denominator 2009-08-01 2009-08-31 51 to 70 Both 0 617 51.09 - -
Outcome 2009-08-01 2009-08-31 51 to 70 Both 0 - - 5 9,785.89 (3,177.45 - 22,836.99)
Denominator 2009-09-01 2009-09-30 51 to 70 Both 0 609 49.19 - -
Outcome 2009-09-01 2009-09-30 51 to 70 Both 0 - - 9 18,294.91 (8,365.60 - 34,729.45)
Denominator 2009-10-01 2009-10-31 51 to 70 Both 0 613 50.98 - -
Outcome 2009-10-01 2009-10-31 51 to 70 Both 0 - - 3 5,884.43 (1,213.51 - 17,196.80)
Denominator 2009-11-01 2009-11-30 51 to 70 Both 0 616 49.36 - -
Outcome 2009-11-01 2009-11-30 51 to 70 Both 0 - - 4 8,103.56 (2,207.95 - 20,748.34)
Denominator 2009-12-01 2009-12-31 51 to 70 Both 0 613 51.05 - -
Outcome 2009-12-01 2009-12-31 51 to 70 Both 0 - - 4 7,835.46 (2,134.90 - 20,061.88)
Denominator 2010-01-01 2010-01-31 51 to 70 Both 0 601 50.34 - -
Outcome 2010-01-01 2010-01-31 51 to 70 Both 0 - - 5 9,933.45 (3,225.36 - 23,181.35)
Denominator 2010-02-01 2010-02-28 51 to 70 Both 0 588 44.77 - -
Outcome 2010-02-01 2010-02-28 51 to 70 Both 0 - - 1 2,233.79 (56.56 - 12,445.87)
Denominator 2010-03-01 2010-03-31 51 to 70 Both 0 582 48.89 - -
Outcome 2010-03-01 2010-03-31 51 to 70 Both 0 - - 4 8,181.63 (2,229.22 - 20,948.23)
Denominator 2010-04-01 2010-04-30 51 to 70 Both 0 576 46.84 - -
Outcome 2010-04-01 2010-04-30 51 to 70 Both 0 - - 3 6,405.33 (1,320.93 - 18,719.09)
Denominator 2010-05-01 2010-05-31 51 to 70 Both 0 575 47.75 - -
Outcome 2010-05-01 2010-05-31 51 to 70 Both 0 - - 6 12,564.39 (4,610.91 - 27,347.39)
Denominator 2010-06-01 2010-06-30 51 to 70 Both 0 557 45.21 - -
Outcome 2010-06-01 2010-06-30 51 to 70 Both 0 - - 3 6,635.26 (1,368.35 - 19,391.04)
Denominator 2010-07-01 2010-07-31 51 to 70 Both 0 545 45.59 - -
Outcome 2010-07-01 2010-07-31 51 to 70 Both 0 - - 4 8,773.66 (2,390.53 - 22,464.06)
Denominator 2010-08-01 2010-08-31 51 to 70 Both 0 529 44.40 - -
Outcome 2010-08-01 2010-08-31 51 to 70 Both 0 - - 1 2,252.40 (57.03 - 12,549.59)
Denominator 2010-09-01 2010-09-30 51 to 70 Both 0 522 41.95 - -
Outcome 2010-09-01 2010-09-30 51 to 70 Both 0 - - 3 7,151.54 (1,474.82 - 20,899.84)
Denominator 2010-10-01 2010-10-31 51 to 70 Both 0 513 43.08 - -
Outcome 2010-10-01 2010-10-31 51 to 70 Both 0 - - 1 2,321.53 (58.78 - 12,934.75)
Denominator 2010-11-01 2010-11-30 51 to 70 Both 0 504 40.77 - -
Outcome 2010-11-01 2010-11-30 51 to 70 Both 0 - - 6 14,717.06 (5,400.90 - 32,032.85)
Denominator 2010-12-01 2010-12-31 51 to 70 Both 0 491 41.09 - -
Outcome 2010-12-01 2010-12-31 51 to 70 Both 0 - - 1 2,433.86 (61.62 - 13,560.60)
Denominator 2011-01-01 2011-01-31 51 to 70 Both 0 481 40.16 - -
Outcome 2011-01-01 2011-01-31 51 to 70 Both 0 - - 7 17,428.54 (7,007.18 - 35,909.46)
Denominator 2011-02-01 2011-02-28 51 to 70 Both 0 470 35.43 - -
Outcome 2011-02-01 2011-02-28 51 to 70 Both 0 - - 5 14,111.14 (4,581.85 - 32,930.69)
Denominator 2011-03-01 2011-03-31 51 to 70 Both 0 463 38.61 - -
Outcome 2011-03-01 2011-03-31 51 to 70 Both 0 - - 3 7,770.21 (1,602.40 - 22,707.85)
Denominator 2011-04-01 2011-04-30 51 to 70 Both 0 454 36.79 - -
Outcome 2011-04-01 2011-04-30 51 to 70 Both 0 - - 4 10,872.82 (2,962.48 - 27,838.72)
Denominator 2011-05-01 2011-05-31 51 to 70 Both 0 444 36.87 - -
Outcome 2011-05-01 2011-05-31 51 to 70 Both 0 - - 3 8,137.14 (1,678.07 - 23,780.17)
Denominator 2011-06-01 2011-06-30 51 to 70 Both 0 434 34.98 - -
Outcome 2011-06-01 2011-06-30 51 to 70 Both 0 - - 3 8,576.58 (1,768.70 - 25,064.39)
Denominator 2011-07-01 2011-07-31 51 to 70 Both 0 427 35.42 - -
Outcome 2011-07-01 2011-07-31 51 to 70 Both 0 - - 4 11,293.06 (3,076.98 - 28,914.71)
Denominator 2011-08-01 2011-08-31 51 to 70 Both 0 420 35.13 - -
Outcome 2011-08-01 2011-08-31 51 to 70 Both 0 - - 1 2,846.16 (72.06 - 15,857.82)
Denominator 2011-09-01 2011-09-30 51 to 70 Both 0 410 33.33 - -
Outcome 2011-09-01 2011-09-30 51 to 70 Both 0 - - 3 9,000.09 (1,856.04 - 26,302.08)
Denominator 2011-10-01 2011-10-31 51 to 70 Both 0 405 33.99 - -
Outcome 2011-10-01 2011-10-31 51 to 70 Both 0 - - 2 5,883.56 (712.53 - 21,253.46)
Denominator 2011-11-01 2011-11-30 51 to 70 Both 0 404 32.66 - -
Outcome 2011-11-01 2011-11-30 51 to 70 Both 0 - - 4 12,246.27 (3,336.70 - 31,355.32)
Denominator 2011-12-01 2011-12-31 51 to 70 Both 0 397 33.17 - -
Outcome 2011-12-01 2011-12-31 51 to 70 Both 0 - - 3 9,044.59 (1,865.21 - 26,432.13)
denominator_cohort_4 Denominator 2008-01-01 2008-01-31 71 to 100 Both 0 559 46.53 - -
Outcome 2008-01-01 2008-01-31 71 to 100 Both 0 - - 3 6,447.45 (1,329.62 - 18,842.19)
Denominator 2008-02-01 2008-02-29 71 to 100 Both 0 555 43.36 - -
Outcome 2008-02-01 2008-02-29 71 to 100 Both 0 - - 4 9,225.31 (2,513.58 - 23,620.44)
Denominator 2008-03-01 2008-03-31 71 to 100 Both 0 560 46.63 - -
Outcome 2008-03-01 2008-03-31 71 to 100 Both 0 - - 5 10,723.17 (3,481.78 - 25,024.30)
Denominator 2008-04-01 2008-04-30 71 to 100 Both 0 561 45.13 - -
Outcome 2008-04-01 2008-04-30 71 to 100 Both 0 - - 8 17,726.18 (7,652.90 - 34,927.63)
Denominator 2008-05-01 2008-05-31 71 to 100 Both 0 556 46.11 - -
Outcome 2008-05-01 2008-05-31 71 to 100 Both 0 - - 8 17,350.57 (7,490.74 - 34,187.54)
Denominator 2008-06-01 2008-06-30 71 to 100 Both 0 555 44.60 - -
Outcome 2008-06-01 2008-06-30 71 to 100 Both 0 - - 6 13,453.82 (4,937.31 - 29,283.30)
Denominator 2008-07-01 2008-07-31 71 to 100 Both 0 555 46.30 - -
Outcome 2008-07-01 2008-07-31 71 to 100 Both 0 - - 4 8,638.75 (2,353.77 - 22,118.63)
Denominator 2008-08-01 2008-08-31 71 to 100 Both 0 559 46.63 - -
Outcome 2008-08-01 2008-08-31 71 to 100 Both 0 - - 5 10,723.17 (3,481.78 - 25,024.30)
Denominator 2008-09-01 2008-09-30 71 to 100 Both 0 559 45.22 - -
Outcome 2008-09-01 2008-09-30 71 to 100 Both 0 - - 4 8,845.45 (2,410.09 - 22,647.86)
Denominator 2008-10-01 2008-10-31 71 to 100 Both 0 554 46.46 - -
Outcome 2008-10-01 2008-10-31 71 to 100 Both 0 - - 5 10,762.87 (3,494.68 - 25,116.95)
Denominator 2008-11-01 2008-11-30 71 to 100 Both 0 555 44.62 - -
Outcome 2008-11-01 2008-11-30 71 to 100 Both 0 - - 8 17,927.57 (7,739.85 - 35,324.46)
Denominator 2008-12-01 2008-12-31 71 to 100 Both 0 549 45.92 - -
Outcome 2008-12-01 2008-12-31 71 to 100 Both 0 - - 4 8,711.56 (2,373.61 - 22,305.05)
Denominator 2009-01-01 2009-01-31 71 to 100 Both 0 551 45.77 - -
Outcome 2009-01-01 2009-01-31 71 to 100 Both 0 - - 4 8,739.54 (2,381.23 - 22,376.69)
Denominator 2009-02-01 2009-02-28 71 to 100 Both 0 551 40.97 - -
Outcome 2009-02-01 2009-02-28 71 to 100 Both 0 - - 7 17,087.34 (6,870.00 - 35,206.45)
Denominator 2009-03-01 2009-03-31 71 to 100 Both 0 547 45.51 - -
Outcome 2009-03-01 2009-03-31 71 to 100 Both 0 - - 4 8,789.08 (2,394.73 - 22,503.55)
Denominator 2009-04-01 2009-04-30 71 to 100 Both 0 545 44.18 - -
Outcome 2009-04-01 2009-04-30 71 to 100 Both 0 - - 2 4,526.83 (548.22 - 16,352.48)
Denominator 2009-05-01 2009-05-31 71 to 100 Both 0 553 45.84 - -
Outcome 2009-05-01 2009-05-31 71 to 100 Both 0 - - 6 13,087.58 (4,802.91 - 28,486.15)
Denominator 2009-06-01 2009-06-30 71 to 100 Both 0 545 43.95 - -
Outcome 2009-06-01 2009-06-30 71 to 100 Both 0 - - 4 9,101.04 (2,479.73 - 23,302.29)
Denominator 2009-07-01 2009-07-31 71 to 100 Both 0 538 44.73 - -
Outcome 2009-07-01 2009-07-31 71 to 100 Both 0 - - 3 6,706.76 (1,383.10 - 19,599.99)
Denominator 2009-08-01 2009-08-31 71 to 100 Both 0 535 44.60 - -
Outcome 2009-08-01 2009-08-31 71 to 100 Both 0 - - 7 15,694.36 (6,309.95 - 32,336.39)
Denominator 2009-09-01 2009-09-30 71 to 100 Both 0 534 43.27 - -
Outcome 2009-09-01 2009-09-30 71 to 100 Both 0 - - 6 13,866.74 (5,088.85 - 30,182.06)
Denominator 2009-10-01 2009-10-31 71 to 100 Both 0 539 44.44 - -
Outcome 2009-10-01 2009-10-31 71 to 100 Both 0 - - 2 4,500.96 (545.09 - 16,259.00)
Denominator 2009-11-01 2009-11-30 71 to 100 Both 0 537 43.04 - -
Outcome 2009-11-01 2009-11-30 71 to 100 Both 0 - - 2 4,647.27 (562.81 - 16,787.54)
Denominator 2009-12-01 2009-12-31 71 to 100 Both 0 541 45.24 - -
Outcome 2009-12-01 2009-12-31 71 to 100 Both 0 - - 2 4,420.57 (535.35 - 15,968.63)
Denominator 2010-01-01 2010-01-31 71 to 100 Both 0 538 44.88 - -
Outcome 2010-01-01 2010-01-31 71 to 100 Both 0 - - 6 13,370.18 (4,906.62 - 29,101.24)
Denominator 2010-02-01 2010-02-28 71 to 100 Both 0 525 39.71 - -
Outcome 2010-02-01 2010-02-28 71 to 100 Both 0 - - 4 10,073.79 (2,744.77 - 25,792.90)
Denominator 2010-03-01 2010-03-31 71 to 100 Both 0 514 43.14 - -
Outcome 2010-03-01 2010-03-31 71 to 100 Both 0 - - 6 13,908.21 (5,104.07 - 30,272.31)
Denominator 2010-04-01 2010-04-30 71 to 100 Both 0 504 40.93 - -
Outcome 2010-04-01 2010-04-30 71 to 100 Both 0 - - 5 12,214.78 (3,966.11 - 28,505.23)
Denominator 2010-05-01 2010-05-31 71 to 100 Both 0 497 41.83 - -
Outcome 2010-05-01 2010-05-31 71 to 100 Both 0 - - 4 9,562.74 (2,605.53 - 24,484.42)
Denominator 2010-06-01 2010-06-30 71 to 100 Both 0 494 40.03 - -
Outcome 2010-06-01 2010-06-30 71 to 100 Both 0 - - 3 7,493.82 (1,545.40 - 21,900.12)
Denominator 2010-07-01 2010-07-31 71 to 100 Both 0 485 40.89 - -
Outcome 2010-07-01 2010-07-31 71 to 100 Both 0 - - 2 4,890.81 (592.30 - 17,667.30)
Denominator 2010-08-01 2010-08-31 71 to 100 Both 0 484 40.28 - -
Outcome 2010-08-01 2010-08-31 71 to 100 Both 0 - - 6 14,896.10 (5,466.61 - 32,422.54)
Denominator 2010-09-01 2010-09-30 71 to 100 Both 0 472 38.04 - -
Outcome 2010-09-01 2010-09-30 71 to 100 Both 0 - - 5 13,145.10 (4,268.18 - 30,676.27)
Denominator 2010-10-01 2010-10-31 71 to 100 Both 0 460 38.86 - -
Outcome 2010-10-01 2010-10-31 71 to 100 Both 0 - - 2 5,147.21 (623.35 - 18,593.49)
Denominator 2010-11-01 2010-11-30 71 to 100 Both 0 459 37.24 - -
Outcome 2010-11-01 2010-11-30 71 to 100 Both 0 - - 6 16,112.57 (5,913.03 - 35,070.29)
Denominator 2010-12-01 2010-12-31 71 to 100 Both 0 451 37.86 - -
Outcome 2010-12-01 2010-12-31 71 to 100 Both 0 - - 4 10,566.36 (2,878.98 - 27,054.07)
Denominator 2011-01-01 2011-01-31 71 to 100 Both 0 445 37.06 - -
Outcome 2011-01-01 2011-01-31 71 to 100 Both 0 - - 7 18,887.27 (7,593.66 - 38,915.00)
Denominator 2011-02-01 2011-02-28 71 to 100 Both 0 434 32.88 - -
Outcome 2011-02-01 2011-02-28 71 to 100 Both 0 - - 5 15,207.27 (4,937.76 - 35,488.71)
Denominator 2011-03-01 2011-03-31 71 to 100 Both 0 426 35.77 - -
Outcome 2011-03-01 2011-03-31 71 to 100 Both 0 - - 3 8,385.74 (1,729.34 - 24,506.70)
Denominator 2011-04-01 2011-04-30 71 to 100 Both 0 419 34.12 - -
Outcome 2011-04-01 2011-04-30 71 to 100 Both 0 - - 2 5,861.84 (709.90 - 21,174.97)
Denominator 2011-05-01 2011-05-31 71 to 100 Both 0 413 34.95 - -
Outcome 2011-05-01 2011-05-31 71 to 100 Both 0 - - 2 5,722.30 (693.00 - 20,670.90)
Denominator 2011-06-01 2011-06-30 71 to 100 Both 0 411 33.17 - -
Outcome 2011-06-01 2011-06-30 71 to 100 Both 0 - - 4 12,060.54 (3,286.09 - 30,879.78)
Denominator 2011-07-01 2011-07-31 71 to 100 Both 0 400 33.69 - -
Outcome 2011-07-01 2011-07-31 71 to 100 Both 0 - - 2 5,937.01 (719.00 - 21,446.52)
Denominator 2011-08-01 2011-08-31 71 to 100 Both 0 395 32.83 - -
Outcome 2011-08-01 2011-08-31 71 to 100 Both 0 - - 3 9,137.98 (1,884.47 - 26,705.07)
Denominator 2011-09-01 2011-09-30 71 to 100 Both 0 386 31.30 - -
Outcome 2011-09-01 2011-09-30 71 to 100 Both 0 - - 6 19,169.94 (7,035.03 - 41,724.89)
Denominator 2011-10-01 2011-10-31 71 to 100 Both 0 378 31.81 - -
Outcome 2011-10-01 2011-10-31 71 to 100 Both 0 - - 3 9,429.81 (1,944.65 - 27,557.91)
Denominator 2011-11-01 2011-11-30 71 to 100 Both 0 372 30.38 - -
Outcome 2011-11-01 2011-11-30 71 to 100 Both 0 - - 1 3,292.07 (83.35 - 18,342.26)
Denominator 2011-12-01 2011-12-31 71 to 100 Both 0 373 31.14 - -
Outcome 2011-12-01 2011-12-31 71 to 100 Both 0 - - 2 6,421.99 (777.73 - 23,198.43)
denominator_cohort_1 Denominator 2008-01-01 2008-01-31 0 to 30 Both 365 699 57.95 - -
Outcome 2008-01-01 2008-01-31 0 to 30 Both 365 - - 3 5,176.97 (1,067.62 - 15,129.29)
Denominator 2008-02-01 2008-02-29 0 to 30 Both 365 702 54.37 - -
Outcome 2008-02-01 2008-02-29 0 to 30 Both 365 - - 3 5,517.34 (1,137.81 - 16,124.02)
Denominator 2008-03-01 2008-03-31 0 to 30 Both 365 703 58.06 - -
Outcome 2008-03-01 2008-03-31 0 to 30 Both 365 - - 7 12,055.66 (4,847.00 - 24,839.27)
Denominator 2008-04-01 2008-04-30 0 to 30 Both 365 693 55.25 - -
Outcome 2008-04-01 2008-04-30 0 to 30 Both 365 - - 7 12,669.00 (5,093.59 - 26,102.97)
Denominator 2008-05-01 2008-05-31 0 to 30 Both 365 681 57.09 - -
Outcome 2008-05-01 2008-05-31 0 to 30 Both 365 - - 3 5,254.86 (1,083.68 - 15,356.93)
Denominator 2008-06-01 2008-06-30 0 to 30 Both 365 683 54.92 - -
Outcome 2008-06-01 2008-06-30 0 to 30 Both 365 - - 7 12,745.58 (5,124.38 - 26,260.77)
Denominator 2008-07-01 2008-07-31 0 to 30 Both 365 677 56.39 - -
Outcome 2008-07-01 2008-07-31 0 to 30 Both 365 - - 4 7,093.58 (1,932.76 - 18,162.39)
Denominator 2008-08-01 2008-08-31 0 to 30 Both 365 682 56.56 - -
Outcome 2008-08-01 2008-08-31 0 to 30 Both 365 - - 6 10,607.45 (3,892.75 - 23,087.96)
Denominator 2008-09-01 2008-09-30 0 to 30 Both 365 677 54.43 - -
Outcome 2008-09-01 2008-09-30 0 to 30 Both 365 - - 8 14,696.70 (6,344.99 - 28,958.35)
Denominator 2008-10-01 2008-10-31 0 to 30 Both 365 681 56.01 - -
Outcome 2008-10-01 2008-10-31 0 to 30 Both 365 - - 3 5,356.38 (1,104.61 - 15,653.61)
Denominator 2008-11-01 2008-11-30 0 to 30 Both 365 673 53.88 - -
Outcome 2008-11-01 2008-11-30 0 to 30 Both 365 - - 4 7,423.77 (2,022.73 - 19,007.79)
Denominator 2008-12-01 2008-12-31 0 to 30 Both 365 677 55.88 - -
Outcome 2008-12-01 2008-12-31 0 to 30 Both 365 - - 8 14,315.88 (6,180.58 - 28,207.99)
Denominator 2009-01-01 2009-01-31 0 to 30 Both 365 668 55.58 - -
Outcome 2009-01-01 2009-01-31 0 to 30 Both 365 - - 7 12,594.91 (5,063.81 - 25,950.33)
Denominator 2009-02-01 2009-02-28 0 to 30 Both 365 656 49.40 - -
Outcome 2009-02-01 2009-02-28 0 to 30 Both 365 - - 6 12,146.73 (4,457.64 - 26,438.32)
Denominator 2009-03-01 2009-03-31 0 to 30 Both 365 648 54.18 - -
Outcome 2009-03-01 2009-03-31 0 to 30 Both 365 - - 2 3,691.60 (447.07 - 13,335.34)
Denominator 2009-04-01 2009-04-30 0 to 30 Both 365 649 52.01 - -
Outcome 2009-04-01 2009-04-30 0 to 30 Both 365 - - 7 13,458.69 (5,411.09 - 27,730.05)
Denominator 2009-05-01 2009-05-31 0 to 30 Both 365 645 52.99 - -
Outcome 2009-05-01 2009-05-31 0 to 30 Both 365 - - 9 16,983.06 (7,765.73 - 32,239.13)
Denominator 2009-06-01 2009-06-30 0 to 30 Both 365 631 50.56 - -
Outcome 2009-06-01 2009-06-30 0 to 30 Both 365 - - 6 11,867.79 (4,355.27 - 25,831.19)
Denominator 2009-07-01 2009-07-31 0 to 30 Both 365 616 51.49 - -
Outcome 2009-07-01 2009-07-31 0 to 30 Both 365 - - 6 11,652.07 (4,276.10 - 25,361.65)
Denominator 2009-08-01 2009-08-31 0 to 30 Both 365 614 50.94 - -
Outcome 2009-08-01 2009-08-31 0 to 30 Both 365 - - 4 7,853.15 (2,139.72 - 20,107.17)
Denominator 2009-09-01 2009-09-30 0 to 30 Both 365 612 49.27 - -
Outcome 2009-09-01 2009-09-30 0 to 30 Both 365 - - 5 10,148.16 (3,295.08 - 23,682.43)
Denominator 2009-10-01 2009-10-31 0 to 30 Both 365 604 50.52 - -
Outcome 2009-10-01 2009-10-31 0 to 30 Both 365 - - 4 7,918.28 (2,157.47 - 20,273.95)
Denominator 2009-11-01 2009-11-30 0 to 30 Both 365 603 48.83 - -
Outcome 2009-11-01 2009-11-30 0 to 30 Both 365 - - 4 8,192.19 (2,232.10 - 20,975.26)
Denominator 2009-12-01 2009-12-31 0 to 30 Both 365 599 49.83 - -
Outcome 2009-12-01 2009-12-31 0 to 30 Both 365 - - 4 8,027.94 (2,187.34 - 20,554.71)
Denominator 2010-01-01 2010-01-31 0 to 30 Both 365 580 48.64 - -
Outcome 2010-01-01 2010-01-31 0 to 30 Both 365 - - 4 8,223.18 (2,240.54 - 21,054.60)
Denominator 2010-02-01 2010-02-28 0 to 30 Both 365 566 43.01 - -
Outcome 2010-02-01 2010-02-28 0 to 30 Both 365 - - 5 11,625.47 (3,774.76 - 27,129.98)
Denominator 2010-03-01 2010-03-31 0 to 30 Both 365 554 46.37 - -
Outcome 2010-03-01 2010-03-31 0 to 30 Both 365 - - 5 10,782.60 (3,501.08 - 25,162.99)
Denominator 2010-04-01 2010-04-30 0 to 30 Both 365 539 43.83 - -
Outcome 2010-04-01 2010-04-30 0 to 30 Both 365 - - 3 6,844.63 (1,411.53 - 20,002.90)
Denominator 2010-05-01 2010-05-31 0 to 30 Both 365 528 44.40 - -
Outcome 2010-05-01 2010-05-31 0 to 30 Both 365 - - 4 9,009.62 (2,454.82 - 23,068.20)
Denominator 2010-06-01 2010-06-30 0 to 30 Both 365 514 41.66 - -
Outcome 2010-06-01 2010-06-30 0 to 30 Both 365 - - 3 7,200.81 (1,484.98 - 21,043.81)
Denominator 2010-07-01 2010-07-31 0 to 30 Both 365 501 42.03 - -
Outcome 2010-07-01 2010-07-31 0 to 30 Both 365 - - 6 14,275.86 (5,238.99 - 31,072.53)
Denominator 2010-08-01 2010-08-31 0 to 30 Both 365 489 40.84 - -
Outcome 2010-08-01 2010-08-31 0 to 30 Both 365 - - 5 12,242.00 (3,974.94 - 28,568.74)
Denominator 2010-09-01 2010-09-30 0 to 30 Both 365 473 38.30 - -
Outcome 2010-09-01 2010-09-30 0 to 30 Both 365 - - 5 13,053.13 (4,238.31 - 30,461.64)
Denominator 2010-10-01 2010-10-31 0 to 30 Both 365 458 38.32 - -
Outcome 2010-10-01 2010-10-31 0 to 30 Both 365 - - 3 7,827.99 (1,614.32 - 22,876.72)
Denominator 2010-11-01 2010-11-30 0 to 30 Both 365 444 36.06 - -
Outcome 2010-11-01 2010-11-30 0 to 30 Both 365 - - 1 2,773.16 (70.21 - 15,451.03)
Denominator 2010-12-01 2010-12-31 0 to 30 Both 365 435 36.26 - -
Outcome 2010-12-01 2010-12-31 0 to 30 Both 365 - - 5 13,789.30 (4,477.35 - 32,179.62)
Denominator 2011-01-01 2011-01-31 0 to 30 Both 365 421 35.18 - -
Outcome 2011-01-01 2011-01-31 0 to 30 Both 365 - - 2 5,684.89 (688.47 - 20,535.77)
Denominator 2011-02-01 2011-02-28 0 to 30 Both 365 410 31.40 - -
Outcome 2011-02-01 2011-02-28 0 to 30 Both 365 - - 1 3,185.22 (80.64 - 17,746.91)
Denominator 2011-03-01 2011-03-31 0 to 30 Both 365 408 34.07 - -
Outcome 2011-03-01 2011-03-31 0 to 30 Both 365 - - 5 14,675.67 (4,765.15 - 34,248.11)
Denominator 2011-04-01 2011-04-30 0 to 30 Both 365 392 32.02 - -
Outcome 2011-04-01 2011-04-30 0 to 30 Both 365 - - 1 3,123.15 (79.07 - 17,401.05)
Denominator 2011-05-01 2011-05-31 0 to 30 Both 365 383 32.02 - -
Outcome 2011-05-01 2011-05-31 0 to 30 Both 365 - - 2 6,245.71 (756.38 - 22,561.64)
Denominator 2011-06-01 2011-06-30 0 to 30 Both 365 373 30.42 - -
Outcome 2011-06-01 2011-06-30 0 to 30 Both 365 - - 1 3,286.99 (83.22 - 18,313.92)
Denominator 2011-07-01 2011-07-31 0 to 30 Both 365 368 30.69 - -
Outcome 2011-07-01 2011-07-31 0 to 30 Both 365 - - 1 3,258.82 (82.51 - 18,156.96)
Denominator 2011-08-01 2011-08-31 0 to 30 Both 365 355 29.81 - -
Outcome 2011-08-01 2011-08-31 0 to 30 Both 365 - - 1 3,354.35 (84.92 - 18,689.26)
Denominator 2011-09-01 2011-09-30 0 to 30 Both 365 348 28.04 - -
Outcome 2011-09-01 2011-09-30 0 to 30 Both 365 - - 4 14,267.37 (3,887.38 - 36,530.14)
Denominator 2011-10-01 2011-10-31 0 to 30 Both 365 336 28.09 - -
Outcome 2011-10-01 2011-10-31 0 to 30 Both 365 - - 2 7,119.21 (862.17 - 25,717.04)
Denominator 2011-11-01 2011-11-30 0 to 30 Both 365 326 26.19 - -
Outcome 2011-11-01 2011-11-30 0 to 30 Both 365 - - 2 7,635.63 (924.71 - 27,582.51)
Denominator 2011-12-01 2011-12-31 0 to 30 Both 365 314 26.37 - -
Outcome 2011-12-01 2011-12-31 0 to 30 Both 365 - - 4 15,168.18 (4,132.82 - 38,836.56)
denominator_cohort_2 Denominator 2008-01-01 2008-01-31 31 to 50 Both 365 664 54.86 - -
Outcome 2008-01-01 2008-01-31 31 to 50 Both 365 - - 4 7,291.82 (1,986.78 - 18,669.95)
Denominator 2008-02-01 2008-02-29 31 to 50 Both 365 664 51.75 - -
Outcome 2008-02-01 2008-02-29 31 to 50 Both 365 - - 3 5,797.33 (1,195.55 - 16,942.24)
Denominator 2008-03-01 2008-03-31 31 to 50 Both 365 669 55.51 - -
Outcome 2008-03-01 2008-03-31 31 to 50 Both 365 - - 6 10,808.28 (3,966.45 - 23,525.07)
Denominator 2008-04-01 2008-04-30 31 to 50 Both 365 671 54.31 - -
Outcome 2008-04-01 2008-04-30 31 to 50 Both 365 - - 2 3,682.70 (445.99 - 13,303.17)
Denominator 2008-05-01 2008-05-31 31 to 50 Both 365 673 56.33 - -
Outcome 2008-05-01 2008-05-31 31 to 50 Both 365 - - 2 3,550.25 (429.95 - 12,824.74)
Denominator 2008-06-01 2008-06-30 31 to 50 Both 365 681 54.64 - -
Outcome 2008-06-01 2008-06-30 31 to 50 Both 365 - - 6 10,980.56 (4,029.67 - 23,900.07)
Denominator 2008-07-01 2008-07-31 31 to 50 Both 365 681 56.67 - -
Outcome 2008-07-01 2008-07-31 31 to 50 Both 365 - - 3 5,293.99 (1,091.75 - 15,471.29)
Denominator 2008-08-01 2008-08-31 31 to 50 Both 365 683 56.64 - -
Outcome 2008-08-01 2008-08-31 31 to 50 Both 365 - - 3 5,296.80 (1,092.33 - 15,479.49)
Denominator 2008-09-01 2008-09-30 31 to 50 Both 365 681 54.61 - -
Outcome 2008-09-01 2008-09-30 31 to 50 Both 365 - - 8 14,650.41 (6,325.00 - 28,867.14)
Denominator 2008-10-01 2008-10-31 31 to 50 Both 365 676 55.67 - -
Outcome 2008-10-01 2008-10-31 31 to 50 Both 365 - - 3 5,388.51 (1,111.24 - 15,747.52)
Denominator 2008-11-01 2008-11-30 31 to 50 Both 365 661 53.43 - -
Outcome 2008-11-01 2008-11-30 31 to 50 Both 365 - - 3 5,614.61 (1,157.87 - 16,408.28)
Denominator 2008-12-01 2008-12-31 31 to 50 Both 365 658 54.23 - -
Outcome 2008-12-01 2008-12-31 31 to 50 Both 365 - - 7 12,908.22 (5,189.77 - 26,595.87)
Denominator 2009-01-01 2009-01-31 31 to 50 Both 365 658 54.33 - -
Outcome 2009-01-01 2009-01-31 31 to 50 Both 365 - - 4 7,362.82 (2,006.12 - 18,851.75)
Denominator 2009-02-01 2009-02-28 31 to 50 Both 365 650 48.99 - -
Outcome 2009-02-01 2009-02-28 31 to 50 Both 365 - - 3 6,124.20 (1,262.96 - 17,897.51)
Denominator 2009-03-01 2009-03-31 31 to 50 Both 365 646 54.05 - -
Outcome 2009-03-01 2009-03-31 31 to 50 Both 365 - - 3 5,550.31 (1,144.61 - 16,220.37)
Denominator 2009-04-01 2009-04-30 31 to 50 Both 365 644 51.87 - -
Outcome 2009-04-01 2009-04-30 31 to 50 Both 365 - - 5 9,639.67 (3,129.97 - 22,495.77)
Denominator 2009-05-01 2009-05-31 31 to 50 Both 365 642 53.68 - -
Outcome 2009-05-01 2009-05-31 31 to 50 Both 365 - - 3 5,589.09 (1,152.61 - 16,333.69)
Denominator 2009-06-01 2009-06-30 31 to 50 Both 365 652 52.11 - -
Outcome 2009-06-01 2009-06-30 31 to 50 Both 365 - - 4 7,676.07 (2,091.47 - 19,653.79)
Denominator 2009-07-01 2009-07-31 31 to 50 Both 365 654 54.36 - -
Outcome 2009-07-01 2009-07-31 31 to 50 Both 365 - - 5 9,198.45 (2,986.71 - 21,466.11)
Denominator 2009-08-01 2009-08-31 31 to 50 Both 365 653 54.20 - -
Outcome 2009-08-01 2009-08-31 31 to 50 Both 365 - - 9 16,605.78 (7,593.22 - 31,522.94)
Denominator 2009-09-01 2009-09-30 31 to 50 Both 365 647 52.11 - -
Outcome 2009-09-01 2009-09-30 31 to 50 Both 365 - - 4 7,676.51 (2,091.59 - 19,654.92)
Denominator 2009-10-01 2009-10-31 31 to 50 Both 365 644 53.44 - -
Outcome 2009-10-01 2009-10-31 31 to 50 Both 365 - - 7 13,098.07 (5,266.10 - 26,987.02)
Denominator 2009-11-01 2009-11-30 31 to 50 Both 365 628 50.63 - -
Outcome 2009-11-01 2009-11-30 31 to 50 Both 365 - - 5 9,875.96 (3,206.70 - 23,047.19)
Denominator 2009-12-01 2009-12-31 31 to 50 Both 365 631 51.93 - -
Outcome 2009-12-01 2009-12-31 31 to 50 Both 365 - - 4 7,702.82 (2,098.76 - 19,722.29)
Denominator 2010-01-01 2010-01-31 31 to 50 Both 365 620 51.94 - -
Outcome 2010-01-01 2010-01-31 31 to 50 Both 365 - - 6 11,550.68 (4,238.90 - 25,140.96)
Denominator 2010-02-01 2010-02-28 31 to 50 Both 365 607 46.00 - -
Outcome 2010-02-01 2010-02-28 31 to 50 Both 365 - - 7 15,217.72 (6,118.31 - 31,354.32)
Denominator 2010-03-01 2010-03-31 31 to 50 Both 365 591 49.31 - -
Outcome 2010-03-01 2010-03-31 31 to 50 Both 365 - - 6 12,168.16 (4,465.50 - 26,484.97)
Denominator 2010-04-01 2010-04-30 31 to 50 Both 365 575 46.77 - -
Outcome 2010-04-01 2010-04-30 31 to 50 Both 365 - - 1 2,138.08 (54.13 - 11,912.60)
Denominator 2010-05-01 2010-05-31 31 to 50 Both 365 566 46.95 - -
Outcome 2010-05-01 2010-05-31 31 to 50 Both 365 - - 4 8,520.43 (2,321.53 - 21,815.68)
Denominator 2010-06-01 2010-06-30 31 to 50 Both 365 547 44.55 - -
Outcome 2010-06-01 2010-06-30 31 to 50 Both 365 - - 1 2,244.52 (56.83 - 12,505.65)
Denominator 2010-07-01 2010-07-31 31 to 50 Both 365 538 45.03 - -
Outcome 2010-07-01 2010-07-31 31 to 50 Both 365 - - 6 13,322.97 (4,889.30 - 28,998.50)
Denominator 2010-08-01 2010-08-31 31 to 50 Both 365 527 44.20 - -
Outcome 2010-08-01 2010-08-31 31 to 50 Both 365 - - 5 11,312.99 (3,673.30 - 26,400.73)
Denominator 2010-09-01 2010-09-30 31 to 50 Both 365 516 42.04 - -
Outcome 2010-09-01 2010-09-30 31 to 50 Both 365 - - 3 7,135.72 (1,471.56 - 20,853.61)
Denominator 2010-10-01 2010-10-31 31 to 50 Both 365 507 42.04 - -
Outcome 2010-10-01 2010-10-31 31 to 50 Both 365 - - 2 4,757.37 (576.14 - 17,185.27)
Denominator 2010-11-01 2010-11-30 31 to 50 Both 365 491 39.77 - -
Outcome 2010-11-01 2010-11-30 31 to 50 Both 365 - - 4 10,057.83 (2,740.42 - 25,752.05)
Denominator 2010-12-01 2010-12-31 31 to 50 Both 365 482 40.22 - -
Outcome 2010-12-01 2010-12-31 31 to 50 Both 365 - - 3 7,458.60 (1,538.14 - 21,797.21)
Denominator 2011-01-01 2011-01-31 31 to 50 Both 365 470 39.17 - -
Outcome 2011-01-01 2011-01-31 31 to 50 Both 365 - - 4 10,211.11 (2,782.18 - 26,144.51)
Denominator 2011-02-01 2011-02-28 31 to 50 Both 365 458 34.62 - -
Outcome 2011-02-01 2011-02-28 31 to 50 Both 365 - - 2 5,777.84 (699.72 - 20,871.55)
Denominator 2011-03-01 2011-03-31 31 to 50 Both 365 446 37.56 - -
Outcome 2011-03-01 2011-03-31 31 to 50 Both 365 - - 1 2,662.19 (67.40 - 14,832.80)
Denominator 2011-04-01 2011-04-30 31 to 50 Both 365 442 36.13 - -
Outcome 2011-04-01 2011-04-30 31 to 50 Both 365 - - 0 0.00 (0.00 - 10,208.89)
Denominator 2011-05-01 2011-05-31 31 to 50 Both 365 440 36.74 - -
Outcome 2011-05-01 2011-05-31 31 to 50 Both 365 - - 4 10,887.61 (2,966.51 - 27,876.61)
Denominator 2011-06-01 2011-06-30 31 to 50 Both 365 430 34.70 - -
Outcome 2011-06-01 2011-06-30 31 to 50 Both 365 - - 5 14,407.15 (4,677.96 - 33,621.47)
Denominator 2011-07-01 2011-07-31 31 to 50 Both 365 419 35.01 - -
Outcome 2011-07-01 2011-07-31 31 to 50 Both 365 - - 3 8,569.23 (1,767.18 - 25,042.91)
Denominator 2011-08-01 2011-08-31 31 to 50 Both 365 407 33.92 - -
Outcome 2011-08-01 2011-08-31 31 to 50 Both 365 - - 5 14,742.31 (4,786.79 - 34,403.62)
Denominator 2011-09-01 2011-09-30 31 to 50 Both 365 396 31.95 - -
Outcome 2011-09-01 2011-09-30 31 to 50 Both 365 - - 3 9,389.38 (1,936.32 - 27,439.74)
Denominator 2011-10-01 2011-10-31 31 to 50 Both 365 386 32.24 - -
Outcome 2011-10-01 2011-10-31 31 to 50 Both 365 - - 1 3,101.35 (78.52 - 17,279.63)
Denominator 2011-11-01 2011-11-30 31 to 50 Both 365 377 30.29 - -
Outcome 2011-11-01 2011-11-30 31 to 50 Both 365 - - 4 13,207.42 (3,598.58 - 33,816.25)
Denominator 2011-12-01 2011-12-31 31 to 50 Both 365 364 30.61 - -
Outcome 2011-12-01 2011-12-31 31 to 50 Both 365 - - 1 3,266.69 (82.71 - 18,200.85)
denominator_cohort_3 Denominator 2008-01-01 2008-01-31 51 to 70 Both 365 631 52.18 - -
Outcome 2008-01-01 2008-01-31 51 to 70 Both 365 - - 5 9,581.67 (3,111.14 - 22,360.41)
Denominator 2008-02-01 2008-02-29 51 to 70 Both 365 631 49.14 - -
Outcome 2008-02-01 2008-02-29 51 to 70 Both 365 - - 6 12,209.51 (4,480.68 - 26,574.97)
Denominator 2008-03-01 2008-03-31 51 to 70 Both 365 631 51.85 - -
Outcome 2008-03-01 2008-03-31 51 to 70 Both 365 - - 1 1,928.68 (48.83 - 10,745.90)
Denominator 2008-04-01 2008-04-30 51 to 70 Both 365 628 49.95 - -
Outcome 2008-04-01 2008-04-30 51 to 70 Both 365 - - 7 14,014.86 (5,634.70 - 28,875.96)
Denominator 2008-05-01 2008-05-31 51 to 70 Both 365 618 51.32 - -
Outcome 2008-05-01 2008-05-31 51 to 70 Both 365 - - 6 11,692.26 (4,290.85 - 25,449.13)
Denominator 2008-06-01 2008-06-30 51 to 70 Both 365 617 49.98 - -
Outcome 2008-06-01 2008-06-30 51 to 70 Both 365 - - 5 10,004.60 (3,248.47 - 23,347.40)
Denominator 2008-07-01 2008-07-31 51 to 70 Both 365 626 51.99 - -
Outcome 2008-07-01 2008-07-31 51 to 70 Both 365 - - 7 13,465.16 (5,413.69 - 27,743.38)
Denominator 2008-08-01 2008-08-31 51 to 70 Both 365 634 52.16 - -
Outcome 2008-08-01 2008-08-31 51 to 70 Both 365 - - 5 9,586.07 (3,112.57 - 22,370.70)
Denominator 2008-09-01 2008-09-30 51 to 70 Both 365 623 50.06 - -
Outcome 2008-09-01 2008-09-30 51 to 70 Both 365 - - 3 5,992.33 (1,235.76 - 17,512.13)
Denominator 2008-10-01 2008-10-31 51 to 70 Both 365 620 51.99 - -
Outcome 2008-10-01 2008-10-31 51 to 70 Both 365 - - 4 7,693.49 (2,096.22 - 19,698.39)
Denominator 2008-11-01 2008-11-30 51 to 70 Both 365 630 50.57 - -
Outcome 2008-11-01 2008-11-30 51 to 70 Both 365 - - 1 1,977.42 (50.06 - 11,017.47)
Denominator 2008-12-01 2008-12-31 51 to 70 Both 365 624 52.10 - -
Outcome 2008-12-01 2008-12-31 51 to 70 Both 365 - - 6 11,515.43 (4,225.96 - 25,064.24)
Denominator 2009-01-01 2009-01-31 51 to 70 Both 365 627 52.06 - -
Outcome 2009-01-01 2009-01-31 51 to 70 Both 365 - - 4 7,683.88 (2,093.60 - 19,673.80)
Denominator 2009-02-01 2009-02-28 51 to 70 Both 365 630 47.51 - -
Outcome 2009-02-01 2009-02-28 51 to 70 Both 365 - - 1 2,104.82 (53.29 - 11,727.31)
Denominator 2009-03-01 2009-03-31 51 to 70 Both 365 629 51.82 - -
Outcome 2009-03-01 2009-03-31 51 to 70 Both 365 - - 10 19,297.94 (9,254.11 - 35,489.60)
Denominator 2009-04-01 2009-04-30 51 to 70 Both 365 617 49.66 - -
Outcome 2009-04-01 2009-04-30 51 to 70 Both 365 - - 7 14,096.14 (5,667.38 - 29,043.43)
Denominator 2009-05-01 2009-05-31 51 to 70 Both 365 622 51.48 - -
Outcome 2009-05-01 2009-05-31 51 to 70 Both 365 - - 3 5,827.84 (1,201.84 - 17,031.44)
Denominator 2009-06-01 2009-06-30 51 to 70 Both 365 618 49.93 - -
Outcome 2009-06-01 2009-06-30 51 to 70 Both 365 - - 6 12,016.82 (4,409.96 - 26,155.57)
Denominator 2009-07-01 2009-07-31 51 to 70 Both 365 618 51.09 - -
Outcome 2009-07-01 2009-07-31 51 to 70 Both 365 - - 8 15,657.42 (6,759.76 - 30,851.35)
Denominator 2009-08-01 2009-08-31 51 to 70 Both 365 617 51.09 - -
Outcome 2009-08-01 2009-08-31 51 to 70 Both 365 - - 5 9,785.89 (3,177.45 - 22,836.99)
Denominator 2009-09-01 2009-09-30 51 to 70 Both 365 609 49.19 - -
Outcome 2009-09-01 2009-09-30 51 to 70 Both 365 - - 9 18,294.91 (8,365.60 - 34,729.45)
Denominator 2009-10-01 2009-10-31 51 to 70 Both 365 613 50.98 - -
Outcome 2009-10-01 2009-10-31 51 to 70 Both 365 - - 3 5,884.43 (1,213.51 - 17,196.80)
Denominator 2009-11-01 2009-11-30 51 to 70 Both 365 616 49.36 - -
Outcome 2009-11-01 2009-11-30 51 to 70 Both 365 - - 4 8,103.56 (2,207.95 - 20,748.34)
Denominator 2009-12-01 2009-12-31 51 to 70 Both 365 613 51.05 - -
Outcome 2009-12-01 2009-12-31 51 to 70 Both 365 - - 4 7,835.46 (2,134.90 - 20,061.88)
Denominator 2010-01-01 2010-01-31 51 to 70 Both 365 601 50.34 - -
Outcome 2010-01-01 2010-01-31 51 to 70 Both 365 - - 5 9,933.45 (3,225.36 - 23,181.35)
Denominator 2010-02-01 2010-02-28 51 to 70 Both 365 588 44.77 - -
Outcome 2010-02-01 2010-02-28 51 to 70 Both 365 - - 1 2,233.79 (56.56 - 12,445.87)
Denominator 2010-03-01 2010-03-31 51 to 70 Both 365 582 48.89 - -
Outcome 2010-03-01 2010-03-31 51 to 70 Both 365 - - 4 8,181.63 (2,229.22 - 20,948.23)
Denominator 2010-04-01 2010-04-30 51 to 70 Both 365 576 46.84 - -
Outcome 2010-04-01 2010-04-30 51 to 70 Both 365 - - 3 6,405.33 (1,320.93 - 18,719.09)
Denominator 2010-05-01 2010-05-31 51 to 70 Both 365 575 47.75 - -
Outcome 2010-05-01 2010-05-31 51 to 70 Both 365 - - 6 12,564.39 (4,610.91 - 27,347.39)
Denominator 2010-06-01 2010-06-30 51 to 70 Both 365 556 45.16 - -
Outcome 2010-06-01 2010-06-30 51 to 70 Both 365 - - 3 6,643.78 (1,370.11 - 19,415.95)
Denominator 2010-07-01 2010-07-31 51 to 70 Both 365 544 45.54 - -
Outcome 2010-07-01 2010-07-31 51 to 70 Both 365 - - 4 8,783.68 (2,393.26 - 22,489.71)
Denominator 2010-08-01 2010-08-31 51 to 70 Both 365 529 44.40 - -
Outcome 2010-08-01 2010-08-31 51 to 70 Both 365 - - 1 2,252.40 (57.03 - 12,549.59)
Denominator 2010-09-01 2010-09-30 51 to 70 Both 365 522 41.95 - -
Outcome 2010-09-01 2010-09-30 51 to 70 Both 365 - - 3 7,151.54 (1,474.82 - 20,899.84)
Denominator 2010-10-01 2010-10-31 51 to 70 Both 365 513 43.08 - -
Outcome 2010-10-01 2010-10-31 51 to 70 Both 365 - - 1 2,321.53 (58.78 - 12,934.75)
Denominator 2010-11-01 2010-11-30 51 to 70 Both 365 504 40.77 - -
Outcome 2010-11-01 2010-11-30 51 to 70 Both 365 - - 6 14,717.06 (5,400.90 - 32,032.85)
Denominator 2010-12-01 2010-12-31 51 to 70 Both 365 490 41.03 - -
Outcome 2010-12-01 2010-12-31 51 to 70 Both 365 - - 1 2,436.94 (61.70 - 13,577.78)
Denominator 2011-01-01 2011-01-31 51 to 70 Both 365 480 40.08 - -
Outcome 2011-01-01 2011-01-31 51 to 70 Both 365 - - 7 17,465.51 (7,022.04 - 35,985.62)
Denominator 2011-02-01 2011-02-28 51 to 70 Both 365 469 35.36 - -
Outcome 2011-02-01 2011-02-28 51 to 70 Both 365 - - 5 14,141.47 (4,591.70 - 33,001.48)
Denominator 2011-03-01 2011-03-31 51 to 70 Both 365 461 38.49 - -
Outcome 2011-03-01 2011-03-31 51 to 70 Both 365 - - 3 7,795.04 (1,607.53 - 22,780.42)
Denominator 2011-04-01 2011-04-30 51 to 70 Both 365 453 36.66 - -
Outcome 2011-04-01 2011-04-30 51 to 70 Both 365 - - 4 10,910.18 (2,972.66 - 27,934.40)
Denominator 2011-05-01 2011-05-31 51 to 70 Both 365 443 36.78 - -
Outcome 2011-05-01 2011-05-31 51 to 70 Both 365 - - 3 8,155.94 (1,681.95 - 23,835.12)
Denominator 2011-06-01 2011-06-30 51 to 70 Both 365 433 34.90 - -
Outcome 2011-06-01 2011-06-30 51 to 70 Both 365 - - 3 8,596.73 (1,772.85 - 25,123.29)
Denominator 2011-07-01 2011-07-31 51 to 70 Both 365 427 35.36 - -
Outcome 2011-07-01 2011-07-31 51 to 70 Both 365 - - 4 11,311.58 (3,082.02 - 28,962.13)
Denominator 2011-08-01 2011-08-31 51 to 70 Both 365 419 35.06 - -
Outcome 2011-08-01 2011-08-31 51 to 70 Both 365 - - 1 2,852.17 (72.21 - 15,891.28)
Denominator 2011-09-01 2011-09-30 51 to 70 Both 365 409 33.25 - -
Outcome 2011-09-01 2011-09-30 51 to 70 Both 365 - - 3 9,022.28 (1,860.61 - 26,366.95)
Denominator 2011-10-01 2011-10-31 51 to 70 Both 365 404 33.91 - -
Outcome 2011-10-01 2011-10-31 51 to 70 Both 365 - - 2 5,898.31 (714.31 - 21,306.74)
Denominator 2011-11-01 2011-11-30 51 to 70 Both 365 403 32.58 - -
Outcome 2011-11-01 2011-11-30 51 to 70 Both 365 - - 4 12,277.47 (3,345.20 - 31,435.20)
Denominator 2011-12-01 2011-12-31 51 to 70 Both 365 396 33.08 - -
Outcome 2011-12-01 2011-12-31 51 to 70 Both 365 - - 3 9,067.83 (1,870.00 - 26,500.04)
denominator_cohort_4 Denominator 2008-01-01 2008-01-31 71 to 100 Both 365 524 43.67 - -
Outcome 2008-01-01 2008-01-31 71 to 100 Both 365 - - 3 6,869.08 (1,416.57 - 20,074.35)
Denominator 2008-02-01 2008-02-29 71 to 100 Both 365 526 40.99 - -
Outcome 2008-02-01 2008-02-29 71 to 100 Both 365 - - 4 9,759.43 (2,659.12 - 24,988.02)
Denominator 2008-03-01 2008-03-31 71 to 100 Both 365 534 44.40 - -
Outcome 2008-03-01 2008-03-31 71 to 100 Both 365 - - 5 11,261.26 (3,656.50 - 26,280.03)
Denominator 2008-04-01 2008-04-30 71 to 100 Both 365 536 43.08 - -
Outcome 2008-04-01 2008-04-30 71 to 100 Both 365 - - 8 18,571.40 (8,017.81 - 36,593.05)
Denominator 2008-05-01 2008-05-31 71 to 100 Both 365 533 44.12 - -
Outcome 2008-05-01 2008-05-31 71 to 100 Both 365 - - 8 18,133.19 (7,828.62 - 35,729.61)
Denominator 2008-06-01 2008-06-30 71 to 100 Both 365 537 42.88 - -
Outcome 2008-06-01 2008-06-30 71 to 100 Both 365 - - 6 13,993.52 (5,135.37 - 30,457.99)
Denominator 2008-07-01 2008-07-31 71 to 100 Both 365 536 44.73 - -
Outcome 2008-07-01 2008-07-31 71 to 100 Both 365 - - 4 8,942.34 (2,436.49 - 22,895.95)
Denominator 2008-08-01 2008-08-31 71 to 100 Both 365 543 45.11 - -
Outcome 2008-08-01 2008-08-31 71 to 100 Both 365 - - 5 11,084.26 (3,599.03 - 25,866.97)
Denominator 2008-09-01 2008-09-30 71 to 100 Both 365 548 44.15 - -
Outcome 2008-09-01 2008-09-30 71 to 100 Both 365 - - 4 9,059.41 (2,468.38 - 23,195.68)
Denominator 2008-10-01 2008-10-31 71 to 100 Both 365 544 45.55 - -
Outcome 2008-10-01 2008-10-31 71 to 100 Both 365 - - 5 10,976.47 (3,564.03 - 25,615.41)
Denominator 2008-11-01 2008-11-30 71 to 100 Both 365 550 44.03 - -
Outcome 2008-11-01 2008-11-30 71 to 100 Both 365 - - 8 18,168.19 (7,843.74 - 35,798.58)
Denominator 2008-12-01 2008-12-31 71 to 100 Both 365 547 45.58 - -
Outcome 2008-12-01 2008-12-31 71 to 100 Both 365 - - 4 8,775.78 (2,391.10 - 22,469.48)
Denominator 2009-01-01 2009-01-31 71 to 100 Both 365 551 45.76 - -
Outcome 2009-01-01 2009-01-31 71 to 100 Both 365 - - 4 8,740.69 (2,381.54 - 22,379.63)
Denominator 2009-02-01 2009-02-28 71 to 100 Both 365 551 40.97 - -
Outcome 2009-02-01 2009-02-28 71 to 100 Both 365 - - 7 17,087.34 (6,870.00 - 35,206.45)
Denominator 2009-03-01 2009-03-31 71 to 100 Both 365 547 45.51 - -
Outcome 2009-03-01 2009-03-31 71 to 100 Both 365 - - 4 8,789.08 (2,394.73 - 22,503.55)
Denominator 2009-04-01 2009-04-30 71 to 100 Both 365 545 44.18 - -
Outcome 2009-04-01 2009-04-30 71 to 100 Both 365 - - 2 4,526.83 (548.22 - 16,352.48)
Denominator 2009-05-01 2009-05-31 71 to 100 Both 365 553 45.84 - -
Outcome 2009-05-01 2009-05-31 71 to 100 Both 365 - - 6 13,087.58 (4,802.91 - 28,486.15)
Denominator 2009-06-01 2009-06-30 71 to 100 Both 365 545 43.95 - -
Outcome 2009-06-01 2009-06-30 71 to 100 Both 365 - - 4 9,101.04 (2,479.73 - 23,302.29)
Denominator 2009-07-01 2009-07-31 71 to 100 Both 365 538 44.73 - -
Outcome 2009-07-01 2009-07-31 71 to 100 Both 365 - - 3 6,706.76 (1,383.10 - 19,599.99)
Denominator 2009-08-01 2009-08-31 71 to 100 Both 365 535 44.60 - -
Outcome 2009-08-01 2009-08-31 71 to 100 Both 365 - - 7 15,694.36 (6,309.95 - 32,336.39)
Denominator 2009-09-01 2009-09-30 71 to 100 Both 365 534 43.27 - -
Outcome 2009-09-01 2009-09-30 71 to 100 Both 365 - - 6 13,866.74 (5,088.85 - 30,182.06)
Denominator 2009-10-01 2009-10-31 71 to 100 Both 365 539 44.44 - -
Outcome 2009-10-01 2009-10-31 71 to 100 Both 365 - - 2 4,500.96 (545.09 - 16,259.00)
Denominator 2009-11-01 2009-11-30 71 to 100 Both 365 537 43.04 - -
Outcome 2009-11-01 2009-11-30 71 to 100 Both 365 - - 2 4,647.27 (562.81 - 16,787.54)
Denominator 2009-12-01 2009-12-31 71 to 100 Both 365 541 45.24 - -
Outcome 2009-12-01 2009-12-31 71 to 100 Both 365 - - 2 4,420.57 (535.35 - 15,968.63)
Denominator 2010-01-01 2010-01-31 71 to 100 Both 365 538 44.88 - -
Outcome 2010-01-01 2010-01-31 71 to 100 Both 365 - - 6 13,370.18 (4,906.62 - 29,101.24)
Denominator 2010-02-01 2010-02-28 71 to 100 Both 365 525 39.71 - -
Outcome 2010-02-01 2010-02-28 71 to 100 Both 365 - - 4 10,073.79 (2,744.77 - 25,792.90)
Denominator 2010-03-01 2010-03-31 71 to 100 Both 365 514 43.14 - -
Outcome 2010-03-01 2010-03-31 71 to 100 Both 365 - - 6 13,908.21 (5,104.07 - 30,272.31)
Denominator 2010-04-01 2010-04-30 71 to 100 Both 365 504 40.93 - -
Outcome 2010-04-01 2010-04-30 71 to 100 Both 365 - - 5 12,214.78 (3,966.11 - 28,505.23)
Denominator 2010-05-01 2010-05-31 71 to 100 Both 365 496 41.80 - -
Outcome 2010-05-01 2010-05-31 71 to 100 Both 365 - - 4 9,569.61 (2,607.40 - 24,501.99)
Denominator 2010-06-01 2010-06-30 71 to 100 Both 365 493 39.95 - -
Outcome 2010-06-01 2010-06-30 71 to 100 Both 365 - - 3 7,509.20 (1,548.58 - 21,945.06)
Denominator 2010-07-01 2010-07-31 71 to 100 Both 365 484 40.81 - -
Outcome 2010-07-01 2010-07-31 71 to 100 Both 365 - - 2 4,901.00 (593.53 - 17,704.10)
Denominator 2010-08-01 2010-08-31 71 to 100 Both 365 484 40.21 - -
Outcome 2010-08-01 2010-08-31 71 to 100 Both 365 - - 6 14,920.18 (5,475.44 - 32,474.94)
Denominator 2010-09-01 2010-09-30 71 to 100 Both 365 472 38.04 - -
Outcome 2010-09-01 2010-09-30 71 to 100 Both 365 - - 5 13,145.10 (4,268.18 - 30,676.27)
Denominator 2010-10-01 2010-10-31 71 to 100 Both 365 460 38.86 - -
Outcome 2010-10-01 2010-10-31 71 to 100 Both 365 - - 2 5,147.21 (623.35 - 18,593.49)
Denominator 2010-11-01 2010-11-30 71 to 100 Both 365 459 37.24 - -
Outcome 2010-11-01 2010-11-30 71 to 100 Both 365 - - 6 16,112.57 (5,913.03 - 35,070.29)
Denominator 2010-12-01 2010-12-31 71 to 100 Both 365 450 37.79 - -
Outcome 2010-12-01 2010-12-31 71 to 100 Both 365 - - 4 10,583.97 (2,883.78 - 27,099.17)
Denominator 2011-01-01 2011-01-31 71 to 100 Both 365 444 36.98 - -
Outcome 2011-01-01 2011-01-31 71 to 100 Both 365 - - 7 18,930.69 (7,611.12 - 39,004.45)
Denominator 2011-02-01 2011-02-28 71 to 100 Both 365 433 32.80 - -
Outcome 2011-02-01 2011-02-28 71 to 100 Both 365 - - 5 15,242.97 (4,949.35 - 35,572.01)
Denominator 2011-03-01 2011-03-31 71 to 100 Both 365 425 35.69 - -
Outcome 2011-03-01 2011-03-31 71 to 100 Both 365 - - 3 8,405.48 (1,733.41 - 24,564.38)
Denominator 2011-04-01 2011-04-30 71 to 100 Both 365 418 34.04 - -
Outcome 2011-04-01 2011-04-30 71 to 100 Both 365 - - 2 5,875.96 (711.61 - 21,225.98)
Denominator 2011-05-01 2011-05-31 71 to 100 Both 365 412 34.87 - -
Outcome 2011-05-01 2011-05-31 71 to 100 Both 365 - - 2 5,736.08 (694.67 - 20,720.70)
Denominator 2011-06-01 2011-06-30 71 to 100 Both 365 410 33.08 - -
Outcome 2011-06-01 2011-06-30 71 to 100 Both 365 - - 4 12,090.44 (3,294.24 - 30,956.32)
Denominator 2011-07-01 2011-07-31 71 to 100 Both 365 399 33.63 - -
Outcome 2011-07-01 2011-07-31 71 to 100 Both 365 - - 2 5,947.78 (720.30 - 21,485.42)
Denominator 2011-08-01 2011-08-31 71 to 100 Both 365 395 32.83 - -
Outcome 2011-08-01 2011-08-31 71 to 100 Both 365 - - 3 9,137.98 (1,884.47 - 26,705.07)
Denominator 2011-09-01 2011-09-30 71 to 100 Both 365 385 31.25 - -
Outcome 2011-09-01 2011-09-30 71 to 100 Both 365 - - 6 19,196.93 (7,044.93 - 41,783.63)
Denominator 2011-10-01 2011-10-31 71 to 100 Both 365 377 31.73 - -
Outcome 2011-10-01 2011-10-31 71 to 100 Both 365 - - 3 9,455.07 (1,949.86 - 27,631.74)
Denominator 2011-11-01 2011-11-30 71 to 100 Both 365 371 30.29 - -
Outcome 2011-11-01 2011-11-30 71 to 100 Both 365 - - 1 3,300.98 (83.57 - 18,391.90)
Denominator 2011-12-01 2011-12-31 71 to 100 Both 365 371 31.04 - -
Outcome 2011-12-01 2011-12-31 71 to 100 Both 365 - - 2 6,442.47 (780.21 - 23,272.41)

plotIncidencePopulation()

We can check incidence results are ok so we can look at trends of the denominator population.

plotIncidencePopulation()

We can plot this to understand if our results make sense

plot

estimatePointPrevalence() and estimatePeriodPrevalence()

Create the denominator and calculate point prevalence

cdm <- IncidencePrevalence::mockIncidencePrevalence(
  sampleSize = 50000,
  outPre = 0.5
)

cdm <- generateDenominatorCohortSet(
  cdm = cdm, 
  name = "denominator",
  cohortDateRange = as.Date(c("2008-01-01", "2012-01-01")),
  ageGroup = list(
    c(0, 30),
    c(31, 50),
    c(51, 70),
    c(71, 100)
  )
)
prev <- estimatePointPrevalence(
  cdm = cdm,
  denominatorTable = "denominator",
  outcomeTable = "outcome",
  interval = "Years"
)

estimatePointPrevalence() and estimatePeriodPrevalence()

prev %>%
  glimpse()
Rows: 276
Columns: 13
$ result_id        <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
$ cdm_name         <chr> "mock", "mock", "mock", "mock", "mock", "mock", "mock…
$ group_name       <chr> "denominator_cohort_name &&& outcome_cohort_name", "d…
$ group_level      <chr> "denominator_cohort_1 &&& cohort_1", "denominator_coh…
$ strata_name      <chr> "overall", "overall", "overall", "overall", "overall"…
$ strata_level     <chr> "overall", "overall", "overall", "overall", "overall"…
$ variable_name    <chr> "Denominator", "Outcome", "Outcome", "Outcome", "Outc…
$ variable_level   <chr> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…
$ estimate_name    <chr> "denominator_count", "outcome_count", "prevalence", "…
$ estimate_type    <chr> "integer", "integer", "numeric", "numeric", "numeric"…
$ estimate_value   <chr> "755", "1", "0.00132", "0.00023", "0.00746", "708", "…
$ additional_name  <chr> "prevalence_start_date &&& prevalence_end_date &&& an…
$ additional_level <chr> "2008-01-01 &&& 2008-01-01 &&& years", "2008-01-01 &&…

estimatePointPrevalence() and estimatePeriodPrevalence()

Create the denominator and calculate period prevalence

prev <- estimatePeriodPrevalence(
  cdm = cdm,
  denominatorTable = "denominator",
  outcomeTable = "outcome",
  interval = "months"
)

prev %>%
  glimpse()
Rows: 1,136
Columns: 13
$ result_id        <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
$ cdm_name         <chr> "mock", "mock", "mock", "mock", "mock", "mock", "mock…
$ group_name       <chr> "denominator_cohort_name &&& outcome_cohort_name", "d…
$ group_level      <chr> "denominator_cohort_1 &&& cohort_1", "denominator_coh…
$ strata_name      <chr> "overall", "overall", "overall", "overall", "overall"…
$ strata_level     <chr> "overall", "overall", "overall", "overall", "overall"…
$ variable_name    <chr> "Denominator", "Outcome", "Outcome", "Outcome", "Outc…
$ variable_level   <chr> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…
$ estimate_name    <chr> "denominator_count", "outcome_count", "prevalence", "…
$ estimate_type    <chr> "integer", "integer", "numeric", "numeric", "numeric"…
$ estimate_value   <chr> "766", "4", "0.00522", "0.00203", "0.01335", "764", "…
$ additional_name  <chr> "prevalence_start_date &&& prevalence_end_date &&& an…
$ additional_level <chr> "2008-01-01 &&& 2008-01-31 &&& months", "2008-01-01 &…

estimatePointPrevalence() and estimatePeriodPrevalence()

We can make pretty plots

plot <- plotPrevalence(prev,
              facet = "denominator_age_group")

estimatePointPrevalence() and estimatePeriodPrevalence()

See pretty plots

plot

Overview

  • The Basics
  • Interface
  • More information

Package website

https://darwin-eu.github.io/IncidencePrevalence/

Package paper

https://onlinelibrary.wiley.com/doi/10.1002/pds.5717

CohortCharacteristics

Characterising Cohorts in OMOP CDM

Overview

  • The Basics
  • Interface
  • More information

The Basics

Table one: vital for any epidemiological study

Overview

  • The Basics
  • Interface
  • More information

Interface

install.packages("CohortCharacteristics")

summariseCharacteristics()

con <- dbConnect(duckdb(), dbdir = eunomiaDir())

cdm <- cdmFromCon(
  con = con, cdmSchem = "main", writeSchema = "main", cdmName = "Eunomia"
)

cdm <- generateConceptCohortSet(
  cdm = cdm,
  name = "injuries",
  conceptSet = list(
    "ankle_sprain" = 81151,
    "ankle_fracture" = 4059173,
    "forearm_fracture" = 4278672,
    "hip_fracture" = 4230399
  ),
  end = "event_end_date",
  limit = "all"
)

summariseCharacteristics()

chars <- cdm$injuries |>
  summariseCharacteristics(ageGroup = list(c(0, 49), c(50, Inf)))
chars |>
  glimpse()
Rows: 192
Columns: 13
$ result_id        <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
$ cdm_name         <chr> "Eunomia", "Eunomia", "Eunomia", "Eunomia", "Eunomia"…
$ group_name       <chr> "cohort_name", "cohort_name", "cohort_name", "cohort_…
$ group_level      <chr> "ankle_sprain", "ankle_sprain", "ankle_sprain", "ankl…
$ strata_name      <chr> "overall", "overall", "overall", "overall", "overall"…
$ strata_level     <chr> "overall", "overall", "overall", "overall", "overall"…
$ variable_name    <chr> "Number records", "Number subjects", "Cohort start da…
$ variable_level   <chr> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…
$ estimate_name    <chr> "count", "count", "min", "q25", "median", "q75", "max…
$ estimate_type    <chr> "integer", "integer", "date", "date", "date", "date",…
$ estimate_value   <chr> "1915", "1357", "1912-02-25", "1968-06-15", "1982-11-…
$ additional_name  <chr> "overall", "overall", "overall", "overall", "overall"…
$ additional_level <chr> "overall", "overall", "overall", "overall", "overall"…

tableCharacteristics()

CDM name
Eunomia
Variable name Variable level Estimate name Cohort name
ankle_sprain ankle_fracture forearm_fracture hip_fracture
Number records - N 1,915 464 569 138
Number subjects - N 1,357 427 510 132
Cohort start date - Median [Q25 - Q75] 1982-11-09 [1968-06-15 - 1999-04-13] 1981-01-15 [1965-03-11 - 1997-08-03] 1981-07-24 [1967-03-05 - 2000-12-16] 1996-09-17 [1977-09-20 - 2010-06-22]
Range 1912-02-25 to 2019-05-30 1911-09-07 to 2019-06-23 1917-08-16 to 2019-06-26 1927-12-14 to 2019-05-08
Cohort end date - Median [Q25 - Q75] 1982-12-10 [1968-07-06 - 1999-05-09] 1981-02-28 [1965-04-11 - 1997-10-12] 1981-08-23 [1967-04-10 - 2001-02-27] 1996-11-16 [1977-12-04 - 2010-07-22]
Range 1912-03-10 to 2019-05-30 1911-12-06 to 2019-06-24 1917-11-14 to 2019-06-26 1928-03-13 to 2019-06-07
Age - Median [Q25 - Q75] 21 [9 - 41] 16 [9 - 43] 17 [9 - 46] 40 [13 - 66]
Mean (SD) 26.63 (21.03) 27.38 (24.70) 28.69 (25.97) 40.06 (28.82)
Range 0 to 105 0 to 107 0 to 106 1 to 108
Age group 0 to 49 N (%) 1,587 (82.87%) 367 (79.09%) 440 (77.33%) 87 (63.04%)
50 or above N (%) 328 (17.13%) 97 (20.91%) 129 (22.67%) 51 (36.96%)
Sex Female N (%) 954 (49.82%) 238 (51.29%) 286 (50.26%) 74 (53.62%)
Male N (%) 961 (50.18%) 226 (48.71%) 283 (49.74%) 64 (46.38%)
Prior observation - Median [Q25 - Q75] 7,833 [3,628 - 15,147] 6,030 [3,360 - 16,032] 6,289 [3,390 - 16,847] 14,522 [4,801 - 24,401]
Mean (SD) 9,918.17 (7,672.74) 10,196.57 (9,011.31) 10,670.43 (9,480.30) 14,821.73 (10,521.89)
Range 299 to 38,429 299 to 39,430 299 to 38,943 390 to 39,792
Future observation - Median [Q25 - Q75] 12,868 [6,860 - 18,078] 13,748 [6,878 - 19,331] 13,165 [5,988 - 18,548] 7,798 [2,874 - 14,913]
Mean (SD) 12,865.11 (7,543.50) 13,470.92 (8,215.96) 12,913.27 (7,929.17) 9,167.33 (7,160.81)
Range 0 to 38,403 1 to 39,051 0 to 36,654 0 to 29,045
Days in cohort - Median [Q25 - Q75] 22 [15 - 29] 61 [31 - 91] 61 [31 - 91] 61 [31 - 91]
Mean (SD) 25.02 (8.00) 61.65 (25.38) 62.16 (25.32) 59.26 (24.79)
Range 1 to 37 2 to 92 1 to 91 1 to 91

summariseCharacteristics()

Get some medications to characterise in our injury cohorts

medsCs <- getDrugIngredientCodes(
  cdm = cdm,
  name = c("acetaminophen", "morphine", "warfarin")
)
cdm <- generateConceptCohortSet(
  cdm = cdm,
  name = "meds",
  conceptSet = medsCs,
  end = "event_end_date",
  limit = "all",
  overwrite = TRUE
)

summariseCharacteristics()

Get some conditions to characterise in our injury cohort

cdm <- generateConceptCohortSet(
  cdm = cdm,
  name = "conditions",
  conceptSet = list(
    "viral_sinusitis" = 40481087,
    "acute_viral_pharyngitis" = 4112343,
    "acute_bronchitis" = 260139
  ),
  end = "event_end_date",
  limit = "all"
)

summariseCharacteristics()

We can then look at medications and conditions before the index date of our injury cohort

chars <- cdm$injuries |>
  summariseCharacteristics(cohortIntersectFlag = list(
    "Medications prior to index date" = list(
      targetCohortTable = "meds",
      window = c(-Inf, -1)
    ),
    "Conditions prior to index date" = list(
      targetCohortTable = "conditions",
      window = c(-Inf, -1)
    )
  ),
  demographics = FALSE)

tableCharacteristics()

CDM name
Eunomia
Variable name Variable level Estimate name Cohort name
ankle_sprain ankle_fracture forearm_fracture hip_fracture
Number records - N 1,915 464 569 138
Number subjects - N 1,357 427 510 132
Medications prior to index date 11289 warfarin N (%) 12 (0.63%) 8 (1.72%) 11 (1.93%) 4 (2.90%)
7052 morphine N (%) 15 (0.78%) 1 (0.22%) 2 (0.35%) 2 (1.45%)
161 acetaminophen N (%) 1,530 (79.90%) 357 (76.94%) 447 (78.56%) 119 (86.23%)
Conditions prior to index date Viral sinusitis N (%) 1,493 (77.96%) 351 (75.65%) 447 (78.56%) 120 (86.96%)
Acute bronchitis N (%) 1,203 (62.82%) 292 (62.93%) 359 (63.09%) 102 (73.91%)
Acute viral pharyngitis N (%) 1,308 (68.30%) 319 (68.75%) 397 (69.77%) 104 (75.36%)

Some other fancy functions

We can summarise the cohort attrition of your cohort.

We can summarise all clinical codes in your database.

Overview

  • The Basics
  • Interface
  • More information

Package website

https://darwin-eu.github.io/CohortCharacteristics/

Top tips :)

  • Translating protocols to code is super hard - dont leave it to interpretation
  • Work closely with data analysts - have a statistical analysis plan + protocol
  • Know what you want and the implications of what you want and timings and index dates!

Any questions?