HDS training: Reporting tools

Content

  • Simple manipulations of the summarised_result object.
  • Quarto to create reports.
  • OmopViewer to create shiny apps.

The summarised_result object

The summarised_result object is defined with 13 columns:

omopgenerics::resultColumns()
 [1] "result_id"        "cdm_name"         "group_name"       "group_level"      "strata_name"      "strata_level"    
 [7] "variable_name"    "variable_level"   "estimate_name"    "estimate_type"    "estimate_value"   "additional_name" 
[13] "additional_level"
visOmopResults::mockSummarisedResult() |>
  dplyr::glimpse()
Rows: 126
Columns: 13
$ result_id        <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, …
$ cdm_name         <chr> "mock", "mock", "mock", "mock", "mock", "mock", "mock", "mock", "mock", "mock", "mock", "mock…
$ group_name       <chr> "cohort_name", "cohort_name", "cohort_name", "cohort_name", "cohort_name", "cohort_name", "co…
$ group_level      <chr> "cohort1", "cohort1", "cohort1", "cohort1", "cohort1", "cohort1", "cohort1", "cohort1", "coho…
$ strata_name      <chr> "overall", "age_group &&& sex", "age_group &&& sex", "age_group &&& sex", "age_group &&& sex"…
$ strata_level     <chr> "overall", "<40 &&& Male", ">=40 &&& Male", "<40 &&& Female", ">=40 &&& Female", "Male", "Fem…
$ variable_name    <chr> "number subjects", "number subjects", "number subjects", "number subjects", "number subjects"…
$ variable_level   <chr> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…
$ estimate_name    <chr> "count", "count", "count", "count", "count", "count", "count", "count", "count", "count", "co…
$ estimate_type    <chr> "integer", "integer", "integer", "integer", "integer", "integer", "integer", "integer", "inte…
$ estimate_value   <chr> "94627", "5695047", "6175816", "4994839", "2190852", "640616", "8254000", "4600920", "1600953…
$ additional_name  <chr> "overall", "overall", "overall", "overall", "overall", "overall", "overall", "overall", "over…
$ additional_level <chr> "overall", "overall", "overall", "overall", "overall", "overall", "overall", "overall", "over…

Settings attribute

result <- visOmopResults::mockSummarisedResult()
omopgenerics::settings(result) |>
  dplyr::glimpse()
Rows: 1
Columns: 8
$ result_id       <int> 1
$ result_type     <chr> "mock_summarised_result"
$ package_name    <chr> "visOmopResults"
$ package_version <chr> "1.0.0"
$ group           <chr> "cohort_name"
$ strata          <chr> "age_group &&& sex"
$ additional      <chr> ""
$ min_cell_count  <chr> "0"

Explore the summarised_result object

The best way to explore the summarised_result object is filtering to the result_type of interest and then using the tidy() function:

result |>
  omopgenerics::filterSettings(result_type == "mock_summarised_result") |>
  omopgenerics::tidy() |> # also reexported in visOmopResults and many of the analytics packages (originally from broom)
  print(n = 100)
# A tibble: 72 × 10
   cdm_name cohort_name age_group sex     variable_name   variable_level   count  mean    sd percentage
   <chr>    <chr>       <chr>     <chr>   <chr>           <chr>            <int> <dbl> <dbl>      <dbl>
 1 mock     cohort1     overall   overall number subjects <NA>           6195060 NA    NA         NA   
 2 mock     cohort1     <40       Male    number subjects <NA>           7921623 NA    NA         NA   
 3 mock     cohort1     >=40      Male    number subjects <NA>           9767892 NA    NA         NA   
 4 mock     cohort1     <40       Female  number subjects <NA>           4312228 NA    NA         NA   
 5 mock     cohort1     >=40      Female  number subjects <NA>           5996531 NA    NA         NA   
 6 mock     cohort1     overall   Male    number subjects <NA>           6762596 NA    NA         NA   
 7 mock     cohort1     overall   Female  number subjects <NA>           5019826 NA    NA         NA   
 8 mock     cohort1     <40       overall number subjects <NA>           1078208 NA    NA         NA   
 9 mock     cohort1     >=40      overall number subjects <NA>           9779580 NA    NA         NA   
10 mock     cohort2     overall   overall number subjects <NA>           5651427 NA    NA         NA   
11 mock     cohort2     <40       Male    number subjects <NA>           3568004 NA    NA         NA   
12 mock     cohort2     >=40      Male    number subjects <NA>           9104281 NA    NA         NA   
13 mock     cohort2     <40       Female  number subjects <NA>           9170531 NA    NA         NA   
14 mock     cohort2     >=40      Female  number subjects <NA>           7875339 NA    NA         NA   
15 mock     cohort2     overall   Male    number subjects <NA>           9426397 NA    NA         NA   
16 mock     cohort2     overall   Female  number subjects <NA>           9141886 NA    NA         NA   
17 mock     cohort2     <40       overall number subjects <NA>           2413249 NA    NA         NA   
18 mock     cohort2     >=40      overall number subjects <NA>           1378584 NA    NA         NA   
19 mock     cohort1     overall   overall age             <NA>                NA 36.9   8.39      NA   
20 mock     cohort1     <40       Male    age             <NA>                NA 83.2   3.19      NA   
21 mock     cohort1     >=40      Male    age             <NA>                NA 79.7   8.43      NA   
22 mock     cohort1     <40       Female  age             <NA>                NA 14.3   5.49      NA   
23 mock     cohort1     >=40      Female  age             <NA>                NA 70.0   2.10      NA   
24 mock     cohort1     overall   Male    age             <NA>                NA 92.9   6.29      NA   
25 mock     cohort1     overall   Female  age             <NA>                NA  8.20  9.12      NA   
26 mock     cohort1     <40       overall age             <NA>                NA 98.6   7.84      NA   
27 mock     cohort1     >=40      overall age             <NA>                NA 66.8   8.62      NA   
28 mock     cohort2     overall   overall age             <NA>                NA 40.1   6.12      NA   
29 mock     cohort2     <40       Male    age             <NA>                NA 30.5   8.14      NA   
30 mock     cohort2     >=40      Male    age             <NA>                NA 54.5   7.53      NA   
31 mock     cohort2     <40       Female  age             <NA>                NA 46.3   1.67      NA   
32 mock     cohort2     >=40      Female  age             <NA>                NA 34.1   6.31      NA   
33 mock     cohort2     overall   Male    age             <NA>                NA 38.9   5.64      NA   
34 mock     cohort2     overall   Female  age             <NA>                NA 20.9   5.82      NA   
35 mock     cohort2     <40       overall age             <NA>                NA 81.9   4.51      NA   
36 mock     cohort2     >=40      overall age             <NA>                NA 86.2   6.35      NA   
37 mock     cohort1     overall   overall Medications     Amoxiciline      10909 NA    NA         54.2 
38 mock     cohort1     <40       Male    Medications     Amoxiciline      24461 NA    NA         87.7 
39 mock     cohort1     >=40      Male    Medications     Amoxiciline      97106 NA    NA         10.1 
40 mock     cohort1     <40       Female  Medications     Amoxiciline      80457 NA    NA          2.52
41 mock     cohort1     >=40      Female  Medications     Amoxiciline      99779 NA    NA         24.3 
42 mock     cohort1     overall   Male    Medications     Amoxiciline      38765 NA    NA         42.1 
43 mock     cohort1     overall   Female  Medications     Amoxiciline      42993 NA    NA         99.8 
44 mock     cohort1     <40       overall Medications     Amoxiciline      18302 NA    NA         61.6 
45 mock     cohort1     >=40      overall Medications     Amoxiciline      19409 NA    NA         72.8 
46 mock     cohort2     overall   overall Medications     Amoxiciline      13423 NA    NA         85.8 
47 mock     cohort2     <40       Male    Medications     Amoxiciline      24626 NA    NA         47.2 
48 mock     cohort2     >=40      Male    Medications     Amoxiciline      79528 NA    NA         64.9 
49 mock     cohort2     <40       Female  Medications     Amoxiciline      42835 NA    NA         24.0 
50 mock     cohort2     >=40      Female  Medications     Amoxiciline      20886 NA    NA          5.94
51 mock     cohort2     overall   Male    Medications     Amoxiciline      60144 NA    NA         89.0 
52 mock     cohort2     overall   Female  Medications     Amoxiciline      75159 NA    NA          1.84
53 mock     cohort2     <40       overall Medications     Amoxiciline      82738 NA    NA         84.7 
54 mock     cohort2     >=40      overall Medications     Amoxiciline      35610 NA    NA         93.3 
55 mock     cohort1     overall   overall Medications     Ibuprofen        91537 NA    NA         91.8 
56 mock     cohort1     <40       Male    Medications     Ibuprofen        44156 NA    NA         92.9 
57 mock     cohort1     >=40      Male    Medications     Ibuprofen        60119 NA    NA         20.6 
58 mock     cohort1     <40       Female  Medications     Ibuprofen        93109 NA    NA         31.2 
59 mock     cohort1     >=40      Female  Medications     Ibuprofen        35647 NA    NA         69.7 
60 mock     cohort1     overall   Male    Medications     Ibuprofen        93342 NA    NA         26.2 
61 mock     cohort1     overall   Female  Medications     Ibuprofen        45149 NA    NA         65.3 
62 mock     cohort1     <40       overall Medications     Ibuprofen        45205 NA    NA         47.6 
63 mock     cohort1     >=40      overall Medications     Ibuprofen        51950 NA    NA         54.3 
64 mock     cohort2     overall   overall Medications     Ibuprofen         4823 NA    NA         36.4 
65 mock     cohort2     <40       Male    Medications     Ibuprofen        16278 NA    NA          9.89
66 mock     cohort2     >=40      Male    Medications     Ibuprofen        40798 NA    NA         49.5 
67 mock     cohort2     <40       Female  Medications     Ibuprofen        94400 NA    NA         95.6 
68 mock     cohort2     >=40      Female  Medications     Ibuprofen        83039 NA    NA         55.8 
69 mock     cohort2     overall   Male    Medications     Ibuprofen        84853 NA    NA         67.6 
70 mock     cohort2     overall   Female  Medications     Ibuprofen        77855 NA    NA         12.5 
71 mock     cohort2     <40       overall Medications     Ibuprofen        70256 NA    NA         23.3 
72 mock     cohort2     >=40      overall Medications     Ibuprofen        52713 NA    NA         39.4

Filter the summarised_result object

  • dplyr::filter() it is the normal filter function you specify a column and then you can filter
result |>
  dplyr::filter(variable_level == "Amoxiciline" & strata_name == "overall")
# A tibble: 4 × 13
  result_id cdm_name group_name  group_level strata_name strata_level variable_name variable_level estimate_name
      <int> <chr>    <chr>       <chr>       <chr>       <chr>        <chr>         <chr>          <chr>        
1         1 mock     cohort_name cohort1     overall     overall      Medications   Amoxiciline    count        
2         1 mock     cohort_name cohort2     overall     overall      Medications   Amoxiciline    count        
3         1 mock     cohort_name cohort1     overall     overall      Medications   Amoxiciline    percentage   
4         1 mock     cohort_name cohort2     overall     overall      Medications   Amoxiciline    percentage   
# ℹ 4 more variables: estimate_type <chr>, estimate_value <chr>, additional_name <chr>, additional_level <chr>

Filter the summarised_result object

omopgenerics::settings(result)
# A tibble: 1 × 8
  result_id result_type            package_name   package_version group       strata           additional min_cell_count
      <int> <chr>                  <chr>          <chr>           <chr>       <chr>            <chr>      <chr>         
1         1 mock_summarised_result visOmopResults 1.0.0           cohort_name age_group &&& s… ""         0             
result |>
  omopgenerics::filterSettings(
    result_type == "mock_summarised_result" & 
      package_name == "visOmopResults"
  )
# A tibble: 126 × 13
   result_id cdm_name group_name  group_level strata_name       strata_level  variable_name variable_level estimate_name
       <int> <chr>    <chr>       <chr>       <chr>             <chr>         <chr>         <chr>          <chr>        
 1         1 mock     cohort_name cohort1     overall           overall       number subje… <NA>           count        
 2         1 mock     cohort_name cohort1     age_group &&& sex <40 &&& Male  number subje… <NA>           count        
 3         1 mock     cohort_name cohort1     age_group &&& sex >=40 &&& Male number subje… <NA>           count        
 4         1 mock     cohort_name cohort1     age_group &&& sex <40 &&& Fema… number subje… <NA>           count        
 5         1 mock     cohort_name cohort1     age_group &&& sex >=40 &&& Fem… number subje… <NA>           count        
 6         1 mock     cohort_name cohort1     sex               Male          number subje… <NA>           count        
 7         1 mock     cohort_name cohort1     sex               Female        number subje… <NA>           count        
 8         1 mock     cohort_name cohort1     age_group         <40           number subje… <NA>           count        
 9         1 mock     cohort_name cohort1     age_group         >=40          number subje… <NA>           count        
10         1 mock     cohort_name cohort2     overall           overall       number subje… <NA>           count        
# ℹ 116 more rows
# ℹ 4 more variables: estimate_type <chr>, estimate_value <chr>, additional_name <chr>, additional_level <chr>

Filter the summarised_result object

  • omopgenerics::filterGroup/Strata/Additional() you can filter using the ‘tidy’ version of group, strata or additional.
result |>
  omopgenerics::filterStrata(sex == "Female")
# A tibble: 42 × 13
   result_id cdm_name group_name  group_level strata_name       strata_level  variable_name variable_level estimate_name
       <int> <chr>    <chr>       <chr>       <chr>             <chr>         <chr>         <chr>          <chr>        
 1         1 mock     cohort_name cohort1     age_group &&& sex <40 &&& Fema… number subje… <NA>           count        
 2         1 mock     cohort_name cohort1     age_group &&& sex >=40 &&& Fem… number subje… <NA>           count        
 3         1 mock     cohort_name cohort1     sex               Female        number subje… <NA>           count        
 4         1 mock     cohort_name cohort2     age_group &&& sex <40 &&& Fema… number subje… <NA>           count        
 5         1 mock     cohort_name cohort2     age_group &&& sex >=40 &&& Fem… number subje… <NA>           count        
 6         1 mock     cohort_name cohort2     sex               Female        number subje… <NA>           count        
 7         1 mock     cohort_name cohort1     age_group &&& sex <40 &&& Fema… age           <NA>           mean         
 8         1 mock     cohort_name cohort1     age_group &&& sex >=40 &&& Fem… age           <NA>           mean         
 9         1 mock     cohort_name cohort1     sex               Female        age           <NA>           mean         
10         1 mock     cohort_name cohort2     age_group &&& sex <40 &&& Fema… age           <NA>           mean         
# ℹ 32 more rows
# ℹ 4 more variables: estimate_type <chr>, estimate_value <chr>, additional_name <chr>, additional_level <chr>

Tidy the summarised_result

Import/Export the summarised_result

Although we export and import the summarised_result from csv files it is important that we import and export them with the appropriate functions. This is important to make sure settings are exported and imported correctly.

  • importSummarisedResult() To import a summarised_result object from a csv file.
  • exportSummarisedResult() To create a csv file from a summarised_result object. Note that by default counts will be suppressed with minCellCount = 5.

! Note that readr::write_csv() and readr::read_csv will not export/import settings therefore results will be incomplete.

Cheatsheet

If there is time add a cheatsheet here and give it to everyone

Your turn

Prepare your session:

  1. Create a project (top right of Rstudio + new project)

  2. Install last version of omopgenerics

install.packages("omopgenerics")

  1. Open empty file: tidy_result.R

  2. Create empty folder data

dir.create(here::here("data"))
  1. Download the results that we are going to work with
download.file(
  url = "https://raw.githubusercontent.com/oxford-pharmacoepi/HDS_training_reporting/refs/heads/main/Study/hds_training_results.csv",
  destfile = here::here("data", "results.csv")
)

Your turn

Exercise: (5 minutes)

  • Import the results.
  • How many results types are included?
  • Which are the version of the packages used?
  • Show the tidy version of one of the result_type that you want to analyse

Solution

result <- omopgenerics::importSummarisedResult(here::here("data", "results.csv"))
result |>
  omopgenerics::settings() |>
  dplyr::pull("result_type") |>
  unique()
[1] "summarise_cohort_attrition"               "summarise_proportion_of_patients_covered"
[3] "summarise_characteristics"                "prevalence"                              
[5] "prevalence_attrition"                    
result |>
  omopgenerics::settings() |>
  dplyr::select(package_name, package_version) |>
  dplyr::distinct()
# A tibble: 3 × 2
  package_name          package_version
  <chr>                 <chr>          
1 CohortCharacteristics 0.4.0          
2 DrugUtilisation       0.8.2          
3 IncidencePrevalence   1.0.0          
result |>
  omopgenerics::filterSettings(result_type == "summarise_characteristics") |>
  omopgenerics::tidy()
# A tibble: 4,320 × 19
   cdm_name  cohort_name age_group sex    variable_name variable_level table window value count   min   q25 median   q75
   <chr>     <chr>       <chr>     <chr>  <chr>         <chr>          <chr> <chr>  <chr> <int> <dbl> <dbl>  <dbl> <dbl>
 1 CPRD GOLD amoxicillin overall   overa… Number recor… <NA>           over… overa… over… 30133    NA    NA     NA    NA
 2 CPRD GOLD amoxicillin overall   overa… Number subje… <NA>           over… overa… over… 19457    NA    NA     NA    NA
 3 CPRD GOLD amoxicillin overall   overa… Cohort start… <NA>           over… overa… over…    NA 14610 15299  15995 16869
 4 CPRD GOLD amoxicillin overall   overa… Cohort end d… <NA>           over… overa… over…    NA 14616 15305  16001 16876
 5 CPRD GOLD amoxicillin overall   overa… Age           <NA>           over… overa… over…    NA    NA    NA     NA    NA
 6 CPRD GOLD amoxicillin overall   overa… Age group     0 to 19        over… overa… over…  7155    NA    NA     NA    NA
 7 CPRD GOLD amoxicillin overall   overa… Age group     20 to 39       over… overa… over…  5915    NA    NA     NA    NA
 8 CPRD GOLD amoxicillin overall   overa… Age group     40 to 59       over… overa… over…  7624    NA    NA     NA    NA
 9 CPRD GOLD amoxicillin overall   overa… Age group     60 to 79       over… overa… over…  6997    NA    NA     NA    NA
10 CPRD GOLD amoxicillin overall   overa… Age group     80 to 150      over… overa… over…  2442    NA    NA     NA    NA
# ℹ 4,310 more rows
# ℹ 5 more variables: max <dbl>, mean <dbl>, sd <dbl>, percentage <dbl>, table_name <chr>

Quarto: Why Another Tool?

Quarto enables you to weave together content and executable code into a finished document. To learn more about Quarto see https://quarto.org.

  • We use Shiny for interactive analysis.
  • But what about:
    • Static reports for regulatory submissions?
    • Summaries with tables and figures for publications?
    • Easy export to Word/PDF without manual copy-pasting?
  • Quarto helps us generate structured, automated, and reproducible reports.

Quarto vs. Shiny: Different Purposes

Feature Shiny (Apps) Quarto (Reports)
User Need Interactive dashboards Static reports with analysis
Reproducibility Reacts to user inputs Fixed, version-controlled outputs
Output Format Web-based UI Word, PDF, HTML, PowerPoint
Best For Exploratory data analysis Structured study reports

💡 We need both:

  • Shiny for exploring data.
  • Quarto for final reporting.

Write simple quarto code

Create my first quarto document:

Blank file -> Quarto Doc… -> my_first_quarto.qmd

Use the Render button to generate the html document.

Write simple quarto code

Let’s add some content to the quarto document:

---
title: "My quarto document"
format: html
editor: visual
---

Write simple quarto code

Write simple quarto code

Add some text:

---
title: "My quarto document"
format: html
editor: visual
---
  
We can add some text here

Write simple quarto code

Titles

We can add titles using ‘#’, more symbols lower level:

## Title
### Subtitle
#### Subsubtitle
##### Subsubsubtitle
We can add some text here

Titles

Images

You can easily add images like:

![](relative path to image)
![](myfigure.png)
![](folder/myfigure.png)

Code

The main reason to use quarto is that we can embed code into quarto!

To add code we can use:

```{r}
ggplot2::ggplot(ggplot2::midwest, ggplot2::aes(x=area, y=poptotal)) + 
  ggplot2::geom_point(ggplot2::aes(col=state, size=popdensity)) + 
  ggplot2::geom_smooth(method="loess", se=F) + 
  ggplot2::xlim(c(0, 0.1)) + 
  ggplot2::ylim(c(0, 500000)) + 
  ggplot2::labs(
    subtitle="Area Vs Population", 
    y="Population", 
    x="Area", 
    title="Scatterplot", 
    caption = "Source: midwest"
  )
```

You can add the code chunk with the following button:

Code

Code

Tip

You can hide, messages, warning, output using the following options:

  • message=TRUE/FALSE
  • warning=TRUE/FALSE
  • echo=TRUE/FALSE
  • eval=TRUE/FALSE
```{r, warning=FALSE, message=FALSE, echo=FALSE}
ggplot2::ggplot(ggplot2::midwest, ggplot2::aes(x=area, y=poptotal)) + 
  ggplot2::geom_point(ggplot2::aes(col=state, size=popdensity)) + 
  ggplot2::geom_smooth(method="loess", se=F) + 
  ggplot2::xlim(c(0, 0.1)) + 
  ggplot2::ylim(c(0, 500000)) + 
  ggplot2::labs(subtitle="Area Vs Population", 
       y="Population", 
       x="Area", 
       title="Scatterplot", 
       caption = "Source: midwest")
```

Code

Code

You can also include simple code in the middle of text:

We have 623874 individuals in my report from those 85.4% had the condition of interest.

Output format

By default we’ve used html as output, but several outputs can be used:

See all output formats and options: https://quarto.org/docs/reference/

Your turn

5 minutes

Create a quarto file that:

  • Generates a ‘Microsoft Word’ document

  • Add a title

  • Subtitle (##)

  • A link

  • Some code

# example
ggplot2::ggplot(cars, ggplot2::aes(x = speed, y = dist)) +
  ggplot2::geom_point()

Your turn

---
title: "ggplot2"
format: docx
editor: visual
---

## Plotting with R

ggplot2 is a very powerful R package that allows us to create plots in R. The ggplot2 package is available from [cran](https://cran.r-project.org). There are very nice tutorials in a the [ggplot2 website](https://ggplot2.tidyverse.org).

## Example

Here some simple code that creates an scatter plot:


```{r}
ggplot2::ggplot(cars, ggplot2::aes(x = speed, y = dist)) +
  ggplot2::geom_point()
```

Your turn

Use the omopverse tools in reports

With the help of visOmopResults package, we can use table and plot functions to directly output results in different formats. Examples:

Package Result Function result_type Table Function Plot Function
CohortCharacteristics summariseCharacteristics summarise_characteristics tableCharacteristics plotCharacteristics
IncidencePrevalence estimateIncidence incidence tableIncidence plotIncidence
IncidencePrevalence estimatePeriodPrevalence prevalence tablePrevalence plotPrevalence
DrugUtilisation summariseDrugUtilisation summarise_drug_utilisation tableDrugUtilisation -
DrugUtilisation summariseProportionOfPatientsCovered summarise_proportion_of_patients_covered - plotProportionOfPatientsCovered
OmopSketch summariseOmopSnapshot summarise_omop_snapshot tableOmopSnapshot -

💡 Key Points:

  • Each result function computes the summary/statistics.

  • Table functions generate structured tables.

  • Plot functions provide visual representations.

  • All these functions are backed by visOmopResults for consistency.

Table Output Options

💡 Which one to use?

Type Package Used Best For Key Features
"gt" gt HTML / PDF reports - Publication-quality tables
- Styling, footnotes, citations
"flextable" flextable Word / PowerPoint - Best for MS Word & PPT
- More control over formatting
"tibble" tibble Data wrangling in R - Prints neatly in console
- Not for final reports
"datatable" DT Interactive web reports - JavaScript-powered tables
- Search, filter, and sort features

Create a simple table

result <- omopgenerics::importSummarisedResult(here::here("data"))
CohortCharacteristics::tableCharacteristics(result)
CDM name
CPRD GOLD
Age group Sex Variable name Variable level Estimate name Cohort name
amoxicillin azithromycin codeine metformin tramadol
overall overall Number records - N 30,133 568 16,070 1,397 3,953
Number subjects - N 19,457 530 11,495 1,297 3,289
Cohort start date - Median [Q25 - Q75] 2013-10-17 [2011-11-21 - 2016-03-09] 2014-02-17 [2012-01-28 - 2016-11-17] 2014-02-10 [2012-01-06 - 2016-07-21] 2013-12-10 [2012-01-24 - 2016-08-26] 2013-07-11 [2011-10-07 - 2015-10-19]
Range 2010-01-01 to 2019-12-31 2010-01-06 to 2019-12-03 2010-01-04 to 2019-12-31 2010-01-04 to 2019-12-20 2010-01-04 to 2019-12-30
Cohort end date - Median [Q25 - Q75] 2013-10-23 [2011-11-27 - 2016-03-16] 2014-03-30 [2012-03-15 - 2017-02-07] 2014-03-18 [2012-02-08 - 2016-09-01] 2015-06-16 [2013-03-19 - 2018-05-03] 2013-09-19 [2011-12-12 - 2016-01-29]
Range 2010-01-07 to 2020-01-23 2010-01-08 to 2024-06-09 2010-01-07 to 2024-06-09 2010-02-25 to 2024-06-10 2010-01-17 to 2024-06-09
Age - Median [Q25 - Q75] 45 [21 - 65] 30 [21 - 60] 53 [38 - 68] 59 [47 - 70] 55 [42 - 69]
Mean (SD) 43.16 (26.08) 38.17 (23.85) 52.93 (19.30) 58.18 (15.59) 55.13 (17.38)
Range 1 to 112 1 to 96 2 to 106 10 to 98 14 to 102
Age group 0 to 19 N (%) 7,155 (23.74%) 118 (20.77%) 521 (3.24%) 10 (0.72%) 29 (0.73%)
20 to 39 N (%) 5,915 (19.63%) 225 (39.61%) 3,813 (23.73%) 180 (12.88%) 777 (19.66%)
40 to 59 N (%) 7,624 (25.30%) 78 (13.73%) 5,540 (34.47%) 510 (36.51%) 1,500 (37.95%)
60 to 79 N (%) 6,997 (23.22%) 116 (20.42%) 4,681 (29.13%) 591 (42.30%) 1,320 (33.39%)
80 to 150 N (%) 2,442 (8.10%) 31 (5.46%) 1,515 (9.43%) 106 (7.59%) 327 (8.27%)
Sex Female N (%) 17,311 (57.45%) 343 (60.39%) 9,486 (59.03%) 662 (47.39%) 2,380 (60.21%)
Male N (%) 12,822 (42.55%) 225 (39.61%) 6,584 (40.97%) 735 (52.61%) 1,573 (39.79%)
Prior observation - Median [Q25 - Q75] 3,413 [1,674 - 4,950] 3,647 [2,174 - 5,132] 3,917 [2,373 - 5,328] 3,546 [1,579 - 5,166] 3,757 [2,376 - 5,121]
Mean (SD) 3,503.70 (2,137.64) 3,625.37 (1,951.07) 3,930.88 (2,122.09) 3,603.25 (2,257.94) 3,812.97 (2,043.03)
Range 365 to 11,197 378 to 9,486 365 to 11,385 365 to 10,971 365 to 10,644
Future observation - Median [Q25 - Q75] 1,888 [841 - 3,170] 1,925 [805 - 3,156] 1,950 [859 - 3,167] 1,710 [751 - 2,824] 1,927 [839 - 3,218]
Mean (SD) 2,089.88 (1,436.62) 2,060.82 (1,411.62) 2,106.93 (1,427.46) 1,909.97 (1,352.96) 2,108.90 (1,448.90)
Range 0 to 5,271 15 to 5,218 0 to 5,270 7 to 5,263 1 to 5,267
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 3 [1 - 8] 13 [8 - 28] 214 [56 - 700] 28 [25 - 46]
Mean (SD) 7.71 (8.19) 69.09 (287.24) 38.72 (157.74) 567.35 (822.79) 91.37 (292.96)
Range 1 to 645 1 to 2,919 1 to 5,099 7 to 5,001 1 to 4,700
Number of visits in the year prior - Median [Q25 - Q75] 13.00 [5.00 - 26.00] 16.00 [7.00 - 35.00] 18.00 [8.00 - 30.00] 26.00 [16.00 - 37.00] 25.00 [14.00 - 39.00]
Mean (SD) 18.42 (17.78) 24.23 (24.53) 21.69 (18.16) 28.99 (19.37) 29.04 (21.11)
Range 0.00 to 310.00 0.00 to 171.00 0.00 to 156.00 0.00 to 191.00 0.00 to 312.00
Medications in the year prior D dermatologicals N (%) 9,761 (32.39%) 223 (39.26%) 5,258 (32.72%) 524 (37.51%) 1,557 (39.39%)
N nervous system N (%) 13,906 (46.15%) 283 (49.82%) 8,601 (53.52%) 907 (64.92%) 3,204 (81.05%)
R respiratory system N (%) 10,904 (36.19%) 283 (49.82%) 5,920 (36.84%) 534 (38.22%) 1,961 (49.61%)
S sensory organs N (%) 3,909 (12.97%) 80 (14.08%) 1,958 (12.18%) 187 (13.39%) 570 (14.42%)
A alimentary tract and metabolism N (%) 12,565 (41.70%) 257 (45.25%) 7,966 (49.57%) 871 (62.35%) 2,587 (65.44%)
B blood and blood forming organs N (%) 5,276 (17.51%) 128 (22.54%) 3,564 (22.18%) 345 (24.70%) 1,144 (28.94%)
P antiparasitic products insecticides and repellents N (%) 1,425 (4.73%) 61 (10.74%) 885 (5.51%) 76 (5.44%) 335 (8.47%)
J antiinfectives for systemic use N (%) 11,146 (36.99%) 400 (70.42%) 7,602 (47.31%) 652 (46.67%) 2,083 (52.69%)
G genito urinary system and sex hormones N (%) 6,901 (22.90%) 205 (36.09%) 4,234 (26.35%) 391 (27.99%) 1,148 (29.04%)
M musculo skeletal system N (%) 7,433 (24.67%) 155 (27.29%) 5,535 (34.44%) 437 (31.28%) 2,136 (54.03%)
V various N (%) 1,692 (5.62%) 42 (7.39%) 1,021 (6.35%) 100 (7.16%) 316 (7.99%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 3,562 (11.82%) 153 (26.94%) 2,464 (15.33%) 248 (17.75%) 878 (22.21%)
L antineoplastic and immunomodulating agents N (%) 1,030 (3.42%) 24 (4.23%) 661 (4.11%) 54 (3.87%) 267 (6.75%)
C cardiovascular system N (%) 11,495 (38.15%) 189 (33.27%) 7,332 (45.63%) 952 (68.15%) 2,127 (53.81%)
Conditions any time prior Diseases of the nervous system N (%) 5,957 (19.77%) 125 (22.01%) 3,585 (22.31%) 300 (21.47%) 1,195 (30.23%)
Certain conditions originating in the perinatal period N (%) 849 (2.82%) 19 (3.35%) 616 (3.83%) 439 (31.42%) 179 (4.53%)
Certain infectious and parasitic diseases N (%) 13,262 (44.01%) 275 (48.42%) 7,023 (43.70%) 783 (56.05%) 1,922 (48.62%)
Mental and behavioural disorders N (%) 1,198 (3.98%) 30 (5.28%) 868 (5.40%) 65 (4.65%) 274 (6.93%)
Pregnancy childbirth and the puerperium N (%) 1,034 (3.43%) 30 (5.28%) 606 (3.77%) 67 (4.80%) 132 (3.34%)
Endocrine nutritional and metabolic diseases N (%) 1,564 (5.19%) 30 (5.28%) 1,112 (6.92%) 537 (38.44%) 342 (8.65%)
Neoplasms N (%) 1,278 (4.24%) 19 (3.35%) 853 (5.31%) 81 (5.80%) 259 (6.55%)
Diseases of the digestive system N (%) 4,091 (13.58%) 107 (18.84%) 2,243 (13.96%) 184 (13.17%) 717 (18.14%)
Diseases of the circulatory system N (%) 8,233 (27.32%) 233 (41.02%) 4,556 (28.35%) 716 (51.25%) 1,309 (33.11%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 25,540 (84.76%) 504 (88.73%) 14,438 (89.84%) 1,376 (98.50%) 3,747 (94.79%)
Diseases of the skin and subcutaneous tissue N (%) 7,414 (24.60%) 153 (26.94%) 3,903 (24.29%) 340 (24.34%) 1,137 (28.76%)
Injury poisoning and certain other consequences of external causes N (%) 11,340 (37.63%) 275 (48.42%) 6,602 (41.08%) 586 (41.95%) 1,904 (48.17%)
Diseases of the ear and mastoid process N (%) 1,727 (5.73%) 34 (5.99%) 940 (5.85%) 92 (6.59%) 259 (6.55%)
Diseases of the genitourinary system N (%) 3,298 (10.94%) 94 (16.55%) 2,025 (12.60%) 223 (15.96%) 588 (14.87%)
Diseases of the respiratory system N (%) 5,365 (17.80%) 201 (35.39%) 3,080 (19.17%) 296 (21.19%) 923 (23.35%)
Congenital malformations deformations and chromosomal abnormalities N (%) 185 (0.61%) 5 (0.88%) 92 (0.57%) 6 (0.43%) 28 (0.71%)
Codes for special purposes N (%) 4,564 (15.15%) 106 (18.66%) 3,112 (19.37%) 398 (28.49%) 926 (23.43%)
Diseases of the musculoskeletal system and connective tissue N (%) 9,840 (32.66%) 200 (35.21%) 5,584 (34.75%) 470 (33.64%) 1,732 (43.81%)
Diseases of the eye and adnexa N (%) 2,660 (8.83%) 44 (7.75%) 1,418 (8.82%) 304 (21.76%) 389 (9.84%)
Factors influencing health status and contact with health services N (%) 25,780 (85.55%) 519 (91.37%) 14,524 (90.38%) 1,374 (98.35%) 3,797 (96.05%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 2,307 (7.66%) 68 (11.97%) 1,361 (8.47%) 114 (8.16%) 406 (10.27%)
External causes of morbidity and mortality N (%) 793 (2.63%) 34 (5.99%) 664 (4.13%) 66 (4.72%) 241 (6.10%)
0 to 19 overall Number records - N 7,155 118 521 10 29
Number subjects - N 5,080 114 463 10 28
Cohort start date - Median [Q25 - Q75] 2013-09-10 [2011-11-21 - 2015-12-21] 2013-07-08 [2011-10-20 - 2016-01-08] 2013-07-12 [2011-09-13 - 2016-01-21] 2014-03-29 [2011-09-28 - 2016-06-27] 2012-10-03 [2011-06-17 - 2013-04-11]
Range 2010-01-04 to 2019-12-31 2010-01-06 to 2019-07-01 2010-01-11 to 2019-12-19 2010-10-15 to 2019-03-04 2010-02-19 to 2018-05-17
Cohort end date - Median [Q25 - Q75] 2013-09-16 [2011-11-26 - 2015-12-28] 2013-08-03 [2011-10-21 - 2016-03-28] 2013-07-26 [2011-10-03 - 2016-03-03] 2014-04-24 [2011-11-01 - 2016-09-14] 2012-10-10 [2011-07-14 - 2013-04-18]
Range 2010-01-08 to 2020-01-06 2010-01-08 to 2024-01-22 2010-01-14 to 2020-11-22 2010-11-11 to 2019-03-31 2010-07-19 to 2018-08-20
Age - Median [Q25 - Q75] 6 [3 - 12] 12 [3 - 18] 17 [15 - 19] 17 [15 - 18] 19 [18 - 19]
Mean (SD) 7.44 (5.64) 10.60 (7.20) 16.58 (2.69) 16.10 (2.88) 17.93 (1.49)
Range 1 to 19 1 to 19 2 to 19 10 to 19 14 to 19
Age group 0 to 19 N (%) 7,155 (100.00%) 118 (100.00%) 521 (100.00%) 10 (100.00%) 29 (100.00%)
Sex Female N (%) 3,509 (49.04%) 71 (60.17%) 335 (64.30%) 8 (80.00%) 20 (68.97%)
Male N (%) 3,646 (50.96%) 47 (39.83%) 186 (35.70%) - 9 (31.03%)
Prior observation - Median [Q25 - Q75] 1,655 [778 - 3,063] 2,344 [1,133 - 3,666] 3,869 [2,576 - 5,052] 4,802 [3,408 - 4,952] 3,686 [2,717 - 4,598]
Mean (SD) 2,067.95 (1,507.51) 2,566.98 (1,710.53) 3,719.34 (1,710.59) 3,984.60 (1,864.03) 3,633.34 (1,572.20)
Range 365 to 7,065 378 to 7,217 373 to 7,183 476 to 6,328 412 to 7,102
Future observation - Median [Q25 - Q75] 1,999 [930 - 3,370] 2,119 [1,053 - 3,389] 2,063 [974 - 3,415] 581 [319 - 1,954] 2,492 [1,190 - 4,251]
Mean (SD) 2,192.74 (1,457.75) 2,249.51 (1,439.07) 2,260.56 (1,475.88) 1,274.30 (1,451.58) 2,623.31 (1,697.48)
Range 1 to 5,271 30 to 5,059 6 to 5,263 81 to 4,090 95 to 5,008
Days in cohort - Median [Q25 - Q75] 7 [5 - 7] 3 [1 - 3] 13 [7 - 28] 28 [28 - 56] 28 [8 - 28]
Mean (SD) 7.38 (5.77) 35.98 (270.56) 24.96 (112.77) 51.30 (40.09) 28.34 (33.23)
Range 1 to 141 1 to 2,919 1 to 2,173 28 to 153 4 to 167
Number of visits in the year prior - Median [Q25 - Q75] 6.00 [3.00 - 11.00] 11.00 [5.00 - 20.75] 9.00 [4.00 - 15.00] 8.00 [7.00 - 13.50] 15.00 [11.00 - 22.00]
Mean (SD) 8.11 (8.47) 16.65 (18.69) 10.61 (9.58) 11.60 (11.65) 16.83 (10.72)
Range 0.00 to 107.00 0.00 to 118.00 0.00 to 110.00 0.00 to 42.00 0.00 to 39.00
Medications in the year prior D dermatologicals N (%) 2,161 (30.20%) 46 (38.98%) 173 (33.21%) - 12 (41.38%)
N nervous system N (%) 1,156 (16.16%) 36 (30.51%) 130 (24.95%) - 17 (58.62%)
R respiratory system N (%) 2,249 (31.43%) 55 (46.61%) 218 (41.84%) - 19 (65.52%)
S sensory organs N (%) 958 (13.39%) 20 (16.95%) 50 (9.60%) 0 (0.00%) 5 (17.24%)
A alimentary tract and metabolism N (%) 1,434 (20.04%) 34 (28.81%) 109 (20.92%) - 6 (20.69%)
B blood and blood forming organs N (%) 254 (3.55%) 12 (10.17%) 87 (16.70%) 0 (0.00%) 9 (31.03%)
P antiparasitic products insecticides and repellents N (%) 188 (2.63%) 8 (6.78%) 22 (4.22%) 0 (0.00%) 5 (17.24%)
J antiinfectives for systemic use N (%) 2,968 (41.48%) 93 (78.81%) 275 (52.78%) - 21 (72.41%)
G genito urinary system and sex hormones N (%) 699 (9.77%) 36 (30.51%) 163 (31.29%) - 10 (34.48%)
M musculo skeletal system N (%) 631 (8.82%) 22 (18.64%) 144 (27.64%) 0 (0.00%) 17 (58.62%)
V various N (%) 91 (1.27%) - 26 (4.99%) - 0 (0.00%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 290 (4.05%) 11 (9.32%) 22 (4.22%) 0 (0.00%) 0 (0.00%)
L antineoplastic and immunomodulating agents N (%) 44 (0.61%) - 24 (4.61%) 0 (0.00%) -
C cardiovascular system N (%) 959 (13.40%) 23 (19.49%) 63 (12.09%) 0 (0.00%) 5 (17.24%)
Conditions any time prior Diseases of the nervous system N (%) 1,409 (19.69%) 35 (29.66%) 129 (24.76%) - 10 (34.48%)
Certain conditions originating in the perinatal period N (%) 19 (0.27%) - - - 0 (0.00%)
Certain infectious and parasitic diseases N (%) 3,407 (47.62%) 64 (54.24%) 254 (48.75%) - 18 (62.07%)
Mental and behavioural disorders N (%) 68 (0.95%) - 15 (2.88%) 0 (0.00%) -
Pregnancy childbirth and the puerperium N (%) 65 (0.91%) - 19 (3.65%) 0 (0.00%) 0 (0.00%)
Endocrine nutritional and metabolic diseases N (%) 41 (0.57%) - 12 (2.30%) - -
Neoplasms N (%) 49 (0.68%) - 7 (1.34%) 0 (0.00%) 0 (0.00%)
Diseases of the digestive system N (%) 1,201 (16.79%) 31 (26.27%) 84 (16.12%) 0 (0.00%) 8 (27.59%)
Diseases of the circulatory system N (%) 2,448 (34.21%) 52 (44.07%) 137 (26.30%) - 13 (44.83%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 5,227 (73.05%) 104 (88.14%) 441 (84.64%) 9 (90.00%) 26 (89.66%)
Diseases of the skin and subcutaneous tissue N (%) 1,960 (27.39%) 39 (33.05%) 130 (24.95%) - 12 (41.38%)
Injury poisoning and certain other consequences of external causes N (%) 2,618 (36.59%) 56 (47.46%) 237 (45.49%) - 20 (68.97%)
Diseases of the ear and mastoid process N (%) 494 (6.90%) 11 (9.32%) 33 (6.33%) - -
Diseases of the genitourinary system N (%) 324 (4.53%) 14 (11.86%) 48 (9.21%) - 5 (17.24%)
Diseases of the respiratory system N (%) 2,016 (28.18%) 52 (44.07%) 103 (19.77%) 0 (0.00%) 8 (27.59%)
Congenital malformations deformations and chromosomal abnormalities N (%) 77 (1.08%) - - 0 (0.00%) 0 (0.00%)
Codes for special purposes N (%) 208 (2.91%) 6 (5.08%) 36 (6.91%) - -
Diseases of the musculoskeletal system and connective tissue N (%) 2,368 (33.10%) 46 (38.98%) 180 (34.55%) - 17 (58.62%)
Diseases of the eye and adnexa N (%) 553 (7.73%) 13 (11.02%) 32 (6.14%) - -
Factors influencing health status and contact with health services N (%) 5,434 (75.95%) 106 (89.83%) 429 (82.34%) 8 (80.00%) 28 (96.55%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 593 (8.29%) 17 (14.41%) 56 (10.75%) 0 (0.00%) 6 (20.69%)
External causes of morbidity and mortality N (%) 35 (0.49%) 5 (4.24%) 6 (1.15%) 0 (0.00%) -
20 to 39 overall Number records - N 5,915 225 3,813 180 777
Number subjects - N 4,340 217 2,932 155 666
Cohort start date - Median [Q25 - Q75] 2013-09-11 [2011-10-16 - 2016-03-02] 2014-01-08 [2012-01-05 - 2016-07-25] 2014-03-11 [2012-01-19 - 2016-09-02] 2014-05-28 [2012-08-22 - 2016-10-30] 2013-08-26 [2011-11-10 - 2016-03-31]
Range 2010-01-01 to 2019-12-31 2010-01-14 to 2019-12-03 2010-01-04 to 2019-12-30 2010-01-29 to 2019-12-02 2010-01-05 to 2019-12-24
Cohort end date - Median [Q25 - Q75] 2013-09-17 [2011-10-23 - 2016-03-08] 2014-02-05 [2012-01-14 - 2016-07-25] 2014-04-06 [2012-02-07 - 2016-09-26] 2015-03-06 [2013-01-06 - 2017-04-04] 2013-10-04 [2011-12-22 - 2016-05-15]
Range 2010-01-07 to 2020-01-12 2010-01-14 to 2019-12-12 2010-01-09 to 2024-06-09 2010-02-25 to 2024-06-09 2010-01-22 to 2024-06-09
Age - Median [Q25 - Q75] 30 [25 - 35] 25 [22 - 30] 30 [26 - 35] 33 [29 - 36] 31 [27 - 36]
Mean (SD) 29.96 (5.76) 26.67 (5.39) 30.15 (5.58) 32.27 (4.87) 30.89 (5.37)
Range 20 to 39 20 to 39 20 to 39 20 to 39 20 to 39
Age group 20 to 39 N (%) 5,915 (100.00%) 225 (100.00%) 3,813 (100.00%) 180 (100.00%) 777 (100.00%)
Sex Female N (%) 3,859 (65.24%) 140 (62.22%) 2,384 (62.52%) 128 (71.11%) 496 (63.84%)
Male N (%) 2,056 (34.76%) 85 (37.78%) 1,429 (37.48%) 52 (28.89%) 281 (36.16%)
Prior observation - Median [Q25 - Q75] 3,277 [1,594 - 4,850] 3,798 [2,366 - 5,160] 3,291 [1,519 - 4,960] 2,744 [1,213 - 4,677] 3,322 [1,558 - 4,855]
Mean (SD) 3,418.84 (2,107.83) 3,720.84 (1,932.97) 3,432.46 (2,133.57) 3,097.93 (2,153.83) 3,396.67 (2,102.66)
Range 365 to 10,993 411 to 9,235 365 to 10,620 371 to 10,971 371 to 9,871
Future observation - Median [Q25 - Q75] 1,876 [832 - 3,218] 2,028 [986 - 3,397] 2,049 [918 - 3,254] 1,582 [818 - 2,800] 2,008 [896 - 3,374]
Mean (SD) 2,098.71 (1,454.46) 2,195.92 (1,445.70) 2,177.66 (1,430.34) 1,871.02 (1,299.88) 2,168.17 (1,460.87)
Range 1 to 5,270 16 to 5,141 0 to 5,269 7 to 5,070 1 to 5,259
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 1 [1 - 3] 13 [7 - 28] 69 [28 - 186] 28 [15 - 36]
Mean (SD) 7.45 (4.88) 12.11 (99.38) 29.11 (137.90) 245.54 (522.85) 73.43 (215.76)
Range 1 to 72 1 to 1,427 1 to 3,880 8 to 3,313 2 to 2,219
Number of visits in the year prior - Median [Q25 - Q75] 9.00 [4.00 - 18.00] 9.00 [4.00 - 16.00] 10.00 [5.00 - 19.00] 18.00 [11.00 - 28.00] 16.00 [8.00 - 29.00]
Mean (SD) 13.18 (13.40) 11.85 (10.64) 13.90 (12.87) 22.61 (20.15) 20.52 (17.10)
Range 0.00 to 176.00 0.00 to 58.00 0.00 to 110.00 1.00 to 191.00 0.00 to 159.00
Medications in the year prior D dermatologicals N (%) 1,803 (30.48%) 76 (33.78%) 1,171 (30.71%) 63 (35.00%) 283 (36.42%)
N nervous system N (%) 2,284 (38.61%) 83 (36.89%) 1,550 (40.65%) 93 (51.67%) 551 (70.91%)
R respiratory system N (%) 1,864 (31.51%) 69 (30.67%) 1,219 (31.97%) 61 (33.89%) 368 (47.36%)
S sensory organs N (%) 486 (8.22%) 12 (5.33%) 286 (7.50%) 14 (7.78%) 76 (9.78%)
A alimentary tract and metabolism N (%) 1,661 (28.08%) 56 (24.89%) 1,189 (31.18%) 93 (51.67%) 367 (47.23%)
B blood and blood forming organs N (%) 949 (16.04%) 34 (15.11%) 694 (18.20%) 38 (21.11%) 188 (24.20%)
P antiparasitic products insecticides and repellents N (%) 271 (4.58%) 34 (15.11%) 193 (5.06%) 11 (6.11%) 56 (7.21%)
J antiinfectives for systemic use N (%) 2,159 (36.50%) 123 (54.67%) 1,799 (47.18%) 94 (52.22%) 408 (52.51%)
G genito urinary system and sex hormones N (%) 2,141 (36.20%) 97 (43.11%) 1,310 (34.36%) 59 (32.78%) 291 (37.45%)
M musculo skeletal system N (%) 1,246 (21.07%) 42 (18.67%) 1,054 (27.64%) 43 (23.89%) 383 (49.29%)
V various N (%) 369 (6.24%) 11 (4.89%) 245 (6.43%) 20 (11.11%) 48 (6.18%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 346 (5.85%) 15 (6.67%) 242 (6.35%) 13 (7.22%) 77 (9.91%)
L antineoplastic and immunomodulating agents N (%) 248 (4.19%) 11 (4.89%) 174 (4.56%) 7 (3.89%) 51 (6.56%)
C cardiovascular system N (%) 971 (16.42%) 23 (10.22%) 655 (17.18%) 41 (22.78%) 169 (21.75%)
Conditions any time prior Diseases of the nervous system N (%) 1,100 (18.60%) 40 (17.78%) 858 (22.50%) 36 (20.00%) 214 (27.54%)
Certain conditions originating in the perinatal period N (%) 64 (1.08%) - 50 (1.31%) 56 (31.11%) 10 (1.29%)
Certain infectious and parasitic diseases N (%) 2,470 (41.76%) 90 (40.00%) 1,613 (42.30%) 100 (55.56%) 381 (49.03%)
Mental and behavioural disorders N (%) 409 (6.91%) 15 (6.67%) 326 (8.55%) 14 (7.78%) 85 (10.94%)
Pregnancy childbirth and the puerperium N (%) 642 (10.85%) 21 (9.33%) 387 (10.15%) 41 (22.78%) 71 (9.14%)
Endocrine nutritional and metabolic diseases N (%) 242 (4.09%) 6 (2.67%) 157 (4.12%) 81 (45.00%) 36 (4.63%)
Neoplasms N (%) 174 (2.94%) - 97 (2.54%) - 16 (2.06%)
Diseases of the digestive system N (%) 803 (13.58%) 27 (12.00%) 573 (15.03%) 32 (17.78%) 169 (21.75%)
Diseases of the circulatory system N (%) 1,358 (22.96%) 62 (27.56%) 919 (24.10%) 89 (49.44%) 228 (29.34%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 4,927 (83.30%) 185 (82.22%) 3,225 (84.58%) 177 (98.33%) 714 (91.89%)
Diseases of the skin and subcutaneous tissue N (%) 1,346 (22.76%) 52 (23.11%) 878 (23.03%) 47 (26.11%) 192 (24.71%)
Injury poisoning and certain other consequences of external causes N (%) 2,114 (35.74%) 81 (36.00%) 1,534 (40.23%) 80 (44.44%) 388 (49.94%)
Diseases of the ear and mastoid process N (%) 283 (4.78%) 8 (3.56%) 230 (6.03%) 13 (7.22%) 57 (7.34%)
Diseases of the genitourinary system N (%) 788 (13.32%) 39 (17.33%) 512 (13.43%) 46 (25.56%) 120 (15.44%)
Diseases of the respiratory system N (%) 832 (14.07%) 32 (14.22%) 661 (17.34%) 31 (17.22%) 169 (21.75%)
Congenital malformations deformations and chromosomal abnormalities N (%) 21 (0.36%) - 18 (0.47%) - -
Codes for special purposes N (%) 652 (11.02%) 26 (11.56%) 427 (11.20%) 18 (10.00%) 126 (16.22%)
Diseases of the musculoskeletal system and connective tissue N (%) 1,700 (28.74%) 65 (28.89%) 1,163 (30.50%) 57 (31.67%) 294 (37.84%)
Diseases of the eye and adnexa N (%) 335 (5.66%) 6 (2.67%) 190 (4.98%) 41 (22.78%) 43 (5.53%)
Factors influencing health status and contact with health services N (%) 4,900 (82.84%) 196 (87.11%) 3,271 (85.79%) 174 (96.67%) 734 (94.47%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 457 (7.73%) 14 (6.22%) 348 (9.13%) 11 (6.11%) 75 (9.65%)
External causes of morbidity and mortality N (%) 98 (1.66%) - 106 (2.78%) - 42 (5.41%)
40 to 59 overall Number records - N 7,624 78 5,540 510 1,500
Number subjects - N 5,135 76 4,084 487 1,260
Cohort start date - Median [Q25 - Q75] 2013-09-26 [2011-11-04 - 2016-02-02] 2014-07-31 [2012-06-27 - 2017-04-22] 2014-01-23 [2011-12-23 - 2016-07-07] 2014-01-08 [2012-03-21 - 2016-07-23] 2013-08-01 [2011-10-23 - 2015-09-10]
Range 2010-01-04 to 2019-12-31 2010-01-25 to 2019-09-18 2010-01-04 to 2019-12-30 2010-01-15 to 2019-12-20 2010-01-05 to 2019-12-30
Cohort end date - Median [Q25 - Q75] 2013-10-02 [2011-11-13 - 2016-02-08] 2014-10-15 [2012-07-13 - 2017-07-24] 2014-02-26 [2012-01-31 - 2016-08-17] 2015-07-23 [2013-05-25 - 2018-05-29] 2013-10-28 [2011-12-26 - 2016-01-03]
Range 2010-01-08 to 2020-01-08 2010-01-27 to 2024-03-03 2010-01-07 to 2024-06-09 2010-02-26 to 2024-06-09 2010-01-24 to 2024-06-09
Age - Median [Q25 - Q75] 50 [45 - 55] 50 [45 - 54] 50 [45 - 55] 52 [45 - 56] 50 [45 - 55]
Mean (SD) 49.73 (5.70) 49.32 (5.68) 49.71 (5.67) 50.83 (5.80) 49.87 (5.66)
Range 40 to 59 40 to 59 40 to 59 40 to 59 40 to 59
Age group 40 to 59 N (%) 7,624 (100.00%) 78 (100.00%) 5,540 (100.00%) 510 (100.00%) 1,500 (100.00%)
Sex Female N (%) 4,514 (59.21%) 49 (62.82%) 3,171 (57.24%) 204 (40.00%) 880 (58.67%)
Male N (%) 3,110 (40.79%) 29 (37.18%) 2,369 (42.76%) 306 (60.00%) 620 (41.33%)
Prior observation - Median [Q25 - Q75] 3,841 [2,461 - 5,167] 3,489 [2,311 - 4,892] 3,818 [2,318 - 5,198] 3,394 [1,541 - 5,002] 3,618 [2,266 - 4,916]
Mean (SD) 3,880.16 (1,990.27) 3,653.51 (1,827.82) 3,833.94 (2,064.50) 3,490.65 (2,229.52) 3,658.85 (1,952.13)
Range 365 to 10,833 380 to 7,645 365 to 11,385 369 to 10,781 367 to 10,114
Future observation - Median [Q25 - Q75] 2,086 [999 - 3,425] 2,043 [1,138 - 3,243] 2,206 [1,084 - 3,470] 1,880 [892 - 3,138] 2,177 [1,016 - 3,536]
Mean (SD) 2,266.74 (1,454.56) 2,195.01 (1,408.12) 2,337.65 (1,448.00) 2,050.53 (1,382.92) 2,313.02 (1,470.07)
Range 0 to 5,269 69 to 5,218 4 to 5,270 7 to 5,241 3 to 5,267
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 3 [1 - 8] 13 [8 - 28] 214 [63 - 816] 28 [25 - 47]
Mean (SD) 7.56 (5.21) 91.65 (336.19) 35.86 (154.37) 626.62 (896.82) 104.00 (348.42)
Range 1 to 102 1 to 2,149 1 to 4,527 8 to 4,855 1 to 4,386
Number of visits in the year prior - Median [Q25 - Q75] 14.00 [6.00 - 24.00] 18.50 [11.00 - 36.75] 14.00 [7.00 - 25.00] 22.00 [14.00 - 34.00] 22.00 [12.00 - 34.00]
Mean (SD) 17.50 (16.53) 25.45 (24.59) 18.14 (16.24) 25.42 (17.73) 25.62 (20.60)
Range 0.00 to 310.00 0.00 to 171.00 0.00 to 156.00 0.00 to 166.00 0.00 to 312.00
Medications in the year prior D dermatologicals N (%) 2,112 (27.70%) 27 (34.62%) 1,540 (27.80%) 176 (34.51%) 505 (33.67%)
N nervous system N (%) 3,851 (50.51%) 47 (60.26%) 2,775 (50.09%) 297 (58.24%) 1,182 (78.80%)
R respiratory system N (%) 2,723 (35.72%) 41 (52.56%) 1,950 (35.20%) 186 (36.47%) 719 (47.93%)
S sensory organs N (%) 702 (9.21%) 9 (11.54%) 485 (8.75%) 53 (10.39%) 168 (11.20%)
A alimentary tract and metabolism N (%) 3,156 (41.40%) 43 (55.13%) 2,399 (43.30%) 284 (55.69%) 918 (61.20%)
B blood and blood forming organs N (%) 1,166 (15.29%) 17 (21.79%) 871 (15.72%) 104 (20.39%) 356 (23.73%)
P antiparasitic products insecticides and repellents N (%) 325 (4.26%) 5 (6.41%) 243 (4.39%) 23 (4.51%) 98 (6.53%)
J antiinfectives for systemic use N (%) 2,398 (31.45%) 57 (73.08%) 2,381 (42.98%) 219 (42.94%) 737 (49.13%)
G genito urinary system and sex hormones N (%) 1,760 (23.08%) 21 (26.92%) 1,300 (23.47%) 121 (23.73%) 405 (27.00%)
M musculo skeletal system N (%) 2,152 (28.23%) 21 (26.92%) 1,835 (33.12%) 161 (31.57%) 826 (55.07%)
V various N (%) 360 (4.72%) 6 (7.69%) 240 (4.33%) 21 (4.12%) 110 (7.33%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 940 (12.33%) 28 (35.90%) 751 (13.56%) 81 (15.88%) 293 (19.53%)
L antineoplastic and immunomodulating agents N (%) 292 (3.83%) - 179 (3.23%) 14 (2.75%) 97 (6.47%)
C cardiovascular system N (%) 2,669 (35.01%) 31 (39.74%) 1,989 (35.90%) 302 (59.22%) 665 (44.33%)
Conditions any time prior Diseases of the nervous system N (%) 1,368 (17.94%) 12 (15.38%) 1,118 (20.18%) 101 (19.80%) 436 (29.07%)
Certain conditions originating in the perinatal period N (%) 254 (3.33%) - 183 (3.30%) 161 (31.57%) 57 (3.80%)
Certain infectious and parasitic diseases N (%) 2,846 (37.33%) 34 (43.59%) 2,084 (37.62%) 259 (50.78%) 647 (43.13%)
Mental and behavioural disorders N (%) 414 (5.43%) - 319 (5.76%) 31 (6.08%) 123 (8.20%)
Pregnancy childbirth and the puerperium N (%) 178 (2.33%) - 105 (1.90%) 15 (2.94%) 32 (2.13%)
Endocrine nutritional and metabolic diseases N (%) 425 (5.57%) 5 (6.41%) 333 (6.01%) 189 (37.06%) 122 (8.13%)
Neoplasms N (%) 326 (4.28%) - 232 (4.19%) 21 (4.12%) 81 (5.40%)
Diseases of the digestive system N (%) 821 (10.77%) 16 (20.51%) 661 (11.93%) 57 (11.18%) 254 (16.93%)
Diseases of the circulatory system N (%) 1,696 (22.25%) 30 (38.46%) 1,389 (25.07%) 262 (51.37%) 456 (30.40%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 6,509 (85.38%) 72 (92.31%) 4,838 (87.33%) 499 (97.84%) 1,401 (93.40%)
Diseases of the skin and subcutaneous tissue N (%) 1,648 (21.62%) 19 (24.36%) 1,235 (22.29%) 128 (25.10%) 414 (27.60%)
Injury poisoning and certain other consequences of external causes N (%) 2,469 (32.38%) 36 (46.15%) 1,961 (35.40%) 187 (36.67%) 648 (43.20%)
Diseases of the ear and mastoid process N (%) 403 (5.29%) - 287 (5.18%) 29 (5.69%) 90 (6.00%)
Diseases of the genitourinary system N (%) 844 (11.07%) 12 (15.38%) 604 (10.90%) 64 (12.55%) 200 (13.33%)
Diseases of the respiratory system N (%) 928 (12.17%) 30 (38.46%) 932 (16.82%) 103 (20.20%) 324 (21.60%)
Congenital malformations deformations and chromosomal abnormalities N (%) 30 (0.39%) 0 (0.00%) 21 (0.38%) - 11 (0.73%)
Codes for special purposes N (%) 1,146 (15.03%) 16 (20.51%) 915 (16.52%) 123 (24.12%) 283 (18.87%)
Diseases of the musculoskeletal system and connective tissue N (%) 2,259 (29.63%) 32 (41.03%) 1,782 (32.17%) 170 (33.33%) 622 (41.47%)
Diseases of the eye and adnexa N (%) 513 (6.73%) 5 (6.41%) 365 (6.59%) 97 (19.02%) 126 (8.40%)
Factors influencing health status and contact with health services N (%) 6,501 (85.27%) 71 (91.03%) 4,892 (88.30%) 502 (98.43%) 1,418 (94.53%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 432 (5.67%) 6 (7.69%) 359 (6.48%) 32 (6.27%) 132 (8.80%)
External causes of morbidity and mortality N (%) 176 (2.31%) - 176 (3.18%) 19 (3.73%) 71 (4.73%)
60 to 79 overall Number records - N 6,997 116 4,681 591 1,320
Number subjects - N 4,434 105 3,462 558 1,120
Cohort start date - Median [Q25 - Q75] 2013-12-18 [2011-12-12 - 2016-05-26] 2014-11-05 [2012-08-08 - 2016-12-11] 2014-02-21 [2012-01-17 - 2016-06-29] 2013-09-30 [2011-11-06 - 2016-10-02] 2013-05-29 [2011-08-24 - 2015-10-16]
Range 2010-01-04 to 2019-12-31 2010-03-10 to 2019-11-22 2010-01-04 to 2019-12-31 2010-01-06 to 2019-12-17 2010-01-04 to 2019-12-13
Cohort end date - Median [Q25 - Q75] 2013-12-25 [2011-12-18 - 2016-06-02] 2015-02-26 [2013-01-20 - 2017-09-15] 2014-04-04 [2012-02-15 - 2016-08-21] 2015-07-20 [2013-04-07 - 2018-08-15] 2013-08-17 [2011-11-02 - 2016-02-01]
Range 2010-01-08 to 2020-01-23 2010-03-10 to 2024-06-09 2010-01-09 to 2024-06-09 2010-03-21 to 2024-06-10 2010-01-17 to 2024-06-09
Age - Median [Q25 - Q75] 68 [64 - 73] 68 [64 - 72] 68 [64 - 74] 68 [64 - 73] 69 [64 - 74]
Mean (SD) 68.79 (5.58) 68.50 (5.42) 68.84 (5.61) 68.55 (5.54) 68.82 (5.61)
Range 60 to 79 60 to 79 60 to 79 60 to 79 60 to 79
Age group 60 to 79 N (%) 6,997 (100.00%) 116 (100.00%) 4,681 (100.00%) 591 (100.00%) 1,320 (100.00%)
Sex Female N (%) 3,883 (55.50%) 68 (58.62%) 2,604 (55.63%) 268 (45.35%) 758 (57.42%)
Male N (%) 3,114 (44.50%) 48 (41.38%) 2,077 (44.37%) 323 (54.65%) 562 (42.58%)
Prior observation - Median [Q25 - Q75] 4,329 [2,994 - 5,597] 4,693 [3,201 - 5,560] 4,236 [2,924 - 5,569] 3,795 [1,982 - 5,306] 3,992 [2,740 - 5,303]
Mean (SD) 4,352.12 (2,056.88) 4,339.85 (1,777.26) 4,289.17 (2,073.48) 3,825.93 (2,291.24) 4,085.21 (2,030.00)
Range 365 to 11,197 434 to 7,695 365 to 10,691 365 to 10,441 365 to 10,644
Future observation - Median [Q25 - Q75] 1,925 [913 - 3,085] 1,680 [711 - 2,534] 1,874 [811 - 3,037] 1,681 [748 - 2,822] 1,858 [814 - 3,047]
Mean (SD) 2,087.28 (1,381.60) 1,768.27 (1,263.66) 2,022.55 (1,389.05) 1,914.23 (1,361.06) 2,035.81 (1,414.26)
Range 1 to 5,269 21 to 4,723 0 to 5,270 13 to 5,263 3 to 5,267
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 6 [3 - 105] 14 [9 - 28] 294 [81 - 844] 28 [28 - 53]
Mean (SD) 8.05 (10.46) 207.53 (456.80) 46.31 (178.83) 648.55 (849.87) 91.60 (287.98)
Range 1 to 620 1 to 1,819 1 to 5,099 14 to 5,001 1 to 4,700
Number of visits in the year prior - Median [Q25 - Q75] 24.00 [15.00 - 36.00] 39.50 [28.00 - 61.50] 25.00 [16.00 - 37.00] 29.00 [20.00 - 40.00] 31.00 [21.00 - 43.00]
Mean (SD) 27.44 (18.32) 45.97 (26.48) 28.42 (18.39) 31.83 (17.80) 34.70 (20.18)
Range 0.00 to 156.00 1.00 to 142.00 0.00 to 151.00 0.00 to 142.00 0.00 to 153.00
Medications in the year prior D dermatologicals N (%) 2,575 (36.80%) 55 (47.41%) 1,721 (36.77%) 239 (40.44%) 600 (45.45%)
N nervous system N (%) 4,624 (66.09%) 90 (77.59%) 2,976 (63.58%) 420 (71.07%) 1,147 (86.89%)
R respiratory system N (%) 3,068 (43.85%) 96 (82.76%) 1,944 (41.53%) 234 (39.59%) 684 (51.82%)
S sensory organs N (%) 1,124 (16.06%) 30 (25.86%) 733 (15.66%) 90 (15.23%) 238 (18.03%)
A alimentary tract and metabolism N (%) 4,404 (62.94%) 95 (81.90%) 3,083 (65.86%) 398 (67.34%) 1,022 (77.42%)
B blood and blood forming organs N (%) 1,803 (25.77%) 51 (43.97%) 1,276 (27.26%) 161 (27.24%) 445 (33.71%)
P antiparasitic products insecticides and repellents N (%) 454 (6.49%) 9 (7.76%) 292 (6.24%) 37 (6.26%) 142 (10.76%)
J antiinfectives for systemic use N (%) 2,540 (36.30%) 99 (85.34%) 2,314 (49.43%) 279 (47.21%) 732 (55.45%)
G genito urinary system and sex hormones N (%) 1,662 (23.75%) 38 (32.76%) 1,115 (23.82%) 170 (28.76%) 359 (27.20%)
M musculo skeletal system N (%) 2,471 (35.32%) 50 (43.10%) 1,856 (39.65%) 198 (33.50%) 711 (53.86%)
V various N (%) 540 (7.72%) 15 (12.93%) 330 (7.05%) 46 (7.78%) 124 (9.39%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 1,396 (19.95%) 74 (63.79%) 1,072 (22.90%) 124 (20.98%) 394 (29.85%)
L antineoplastic and immunomodulating agents N (%) 319 (4.56%) 5 (4.31%) 204 (4.36%) 28 (4.74%) 85 (6.44%)
C cardiovascular system N (%) 4,833 (69.07%) 84 (72.41%) 3,331 (71.16%) 507 (85.79%) 1,005 (76.14%)
Conditions any time prior Diseases of the nervous system N (%) 1,460 (20.87%) 29 (25.00%) 1,103 (23.56%) 124 (20.98%) 429 (32.50%)
Certain conditions originating in the perinatal period N (%) 375 (5.36%) 10 (8.62%) 308 (6.58%) 184 (31.13%) 95 (7.20%)
Certain infectious and parasitic diseases N (%) 3,267 (46.69%) 66 (56.90%) 2,266 (48.41%) 351 (59.39%) 690 (52.27%)
Mental and behavioural disorders N (%) 168 (2.40%) 6 (5.17%) 141 (3.01%) 12 (2.03%) 47 (3.56%)
Pregnancy childbirth and the puerperium N (%) 115 (1.64%) - 81 (1.73%) 11 (1.86%) 24 (1.82%)
Endocrine nutritional and metabolic diseases N (%) 626 (8.95%) 12 (10.34%) 497 (10.62%) 221 (37.39%) 155 (11.74%)
Neoplasms N (%) 521 (7.45%) 9 (7.76%) 389 (8.31%) 49 (8.29%) 125 (9.47%)
Diseases of the digestive system N (%) 902 (12.89%) 27 (23.28%) 680 (14.53%) 75 (12.69%) 224 (16.97%)
Diseases of the circulatory system N (%) 1,912 (27.33%) 68 (58.62%) 1,559 (33.30%) 304 (51.44%) 485 (36.74%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 6,499 (92.88%) 112 (96.55%) 4,454 (95.15%) 585 (98.98%) 1,286 (97.42%)
Diseases of the skin and subcutaneous tissue N (%) 1,806 (25.81%) 34 (29.31%) 1,262 (26.96%) 139 (23.52%) 417 (31.59%)
Injury poisoning and certain other consequences of external causes N (%) 2,921 (41.75%) 77 (66.38%) 2,072 (44.26%) 262 (44.33%) 661 (50.08%)
Diseases of the ear and mastoid process N (%) 401 (5.73%) 7 (6.03%) 305 (6.52%) 42 (7.11%) 83 (6.29%)
Diseases of the genitourinary system N (%) 909 (12.99%) 18 (15.52%) 596 (12.73%) 88 (14.89%) 202 (15.30%)
Diseases of the respiratory system N (%) 1,143 (16.34%) 68 (58.62%) 1,035 (22.11%) 136 (23.01%) 331 (25.08%)
Congenital malformations deformations and chromosomal abnormalities N (%) 49 (0.70%) - 39 (0.83%) - 10 (0.76%)
Codes for special purposes N (%) 1,895 (27.08%) 44 (37.93%) 1,327 (28.35%) 208 (35.19%) 429 (32.50%)
Diseases of the musculoskeletal system and connective tissue N (%) 2,583 (36.92%) 46 (39.66%) 1,851 (39.54%) 201 (34.01%) 644 (48.79%)
Diseases of the eye and adnexa N (%) 877 (12.53%) 18 (15.52%) 581 (12.41%) 131 (22.17%) 169 (12.80%)
Factors influencing health status and contact with health services N (%) 6,564 (93.81%) 115 (99.14%) 4,448 (95.02%) 584 (98.82%) 1,295 (98.11%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 564 (8.06%) 20 (17.24%) 431 (9.21%) 57 (9.64%) 144 (10.91%)
External causes of morbidity and mortality N (%) 325 (4.64%) 12 (10.34%) 268 (5.73%) 36 (6.09%) 92 (6.97%)
80 to 150 overall Number records - N 2,442 31 1,515 106 327
Number subjects - N 1,731 28 1,199 106 298
Cohort start date - Median [Q25 - Q75] 2014-01-14 [2012-01-13 - 2016-10-02] 2014-06-20 [2012-10-15 - 2017-06-03] 2014-02-18 [2012-03-01 - 2016-11-13] 2013-07-13 [2011-07-19 - 2016-06-18] 2013-09-02 [2012-01-01 - 2015-09-12]
Range 2010-01-04 to 2019-12-27 2010-02-03 to 2019-10-01 2010-01-04 to 2019-12-31 2010-01-04 to 2019-12-03 2010-01-05 to 2019-12-13
Cohort end date - Median [Q25 - Q75] 2014-01-20 [2012-01-20 - 2016-10-11] 2014-06-26 [2012-12-02 - 2017-06-07] 2014-04-27 [2012-04-21 - 2016-12-25] 2014-11-14 [2012-03-16 - 2017-08-02] 2013-10-13 [2012-03-24 - 2015-11-11]
Range 2010-01-08 to 2020-01-02 2010-03-30 to 2019-10-03 2010-01-12 to 2023-04-18 2010-04-05 to 2024-06-09 2010-01-18 to 2021-09-26
Age - Median [Q25 - Q75] 85 [82 - 89] 85 [82 - 88] 84 [82 - 88] 83 [81 - 86] 84 [82 - 88]
Mean (SD) 85.89 (4.89) 84.97 (3.90) 85.37 (4.49) 83.66 (3.58) 84.94 (4.00)
Range 80 to 112 80 to 96 80 to 106 80 to 98 80 to 102
Age group 80 to 150 N (%) 2,442 (100.00%) 31 (100.00%) 1,515 (100.00%) 106 (100.00%) 327 (100.00%)
Sex Female N (%) 1,546 (63.31%) 15 (48.39%) 992 (65.48%) 54 (50.94%) 226 (69.11%)
Male N (%) 896 (36.69%) 16 (51.61%) 523 (34.52%) 52 (49.06%) 101 (30.89%)
Prior observation - Median [Q25 - Q75] 4,302 [2,671 - 5,756] 4,114 [2,813 - 5,719] 4,515 [2,976 - 5,910] 3,515 [1,712 - 5,232] 4,448 [2,983 - 5,556]
Mean (SD) 4,309.73 (2,295.70) 4,216.77 (2,267.62) 4,505.49 (2,245.75) 3,725.52 (2,274.68) 4,426.13 (2,113.12)
Range 371 to 10,950 397 to 9,486 365 to 10,983 365 to 9,143 371 to 10,298
Future observation - Median [Q25 - Q75] 932 [357 - 1,843] 806 [306 - 1,418] 1,028 [378 - 1,964] 1,128 [504 - 2,046] 975 [406 - 1,870]
Mean (SD) 1,222.40 (1,078.80) 1,119.00 (1,094.19) 1,293.15 (1,091.81) 1,336.04 (1,061.10) 1,281.13 (1,076.77)
Range 0 to 5,266 15 to 4,036 1 to 5,215 37 to 4,137 17 to 4,377
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 6 [3 - 19] 28 [10 - 30] 188 [56 - 593] 28 [22 - 48]
Mean (SD) 8.76 (16.48) 33.84 (69.45) 54.64 (158.21) 424.59 (547.27) 80.70 (183.83)
Range 1 to 645 1 to 342 2 to 2,347 7 to 2,919 3 to 1,579
Number of visits in the year prior - Median [Q25 - Q75] 34.00 [24.00 - 49.00] 58.00 [41.00 - 73.50] 33.00 [23.00 - 47.00] 36.00 [28.00 - 54.75] 37.00 [27.00 - 56.00]
Mean (SD) 38.42 (20.75) 58.42 (22.48) 37.27 (20.44) 42.88 (24.01) 43.25 (22.92)
Range 0.00 to 141.00 27.00 to 124.00 0.00 to 129.00 3.00 to 136.00 0.00 to 129.00
Medications in the year prior D dermatologicals N (%) 1,110 (45.45%) 19 (61.29%) 653 (43.10%) 45 (42.45%) 157 (48.01%)
N nervous system N (%) 1,991 (81.53%) 27 (87.10%) 1,170 (77.23%) 95 (89.62%) 307 (93.88%)
R respiratory system N (%) 1,000 (40.95%) 22 (70.97%) 589 (38.88%) 52 (49.06%) 171 (52.29%)
S sensory organs N (%) 639 (26.17%) 9 (29.03%) 404 (26.67%) 30 (28.30%) 83 (25.38%)
A alimentary tract and metabolism N (%) 1,910 (78.21%) 29 (93.55%) 1,186 (78.28%) 93 (87.74%) 274 (83.79%)
B blood and blood forming organs N (%) 1,104 (45.21%) 14 (45.16%) 636 (41.98%) 42 (39.62%) 146 (44.65%)
P antiparasitic products insecticides and repellents N (%) 187 (7.66%) 5 (16.13%) 135 (8.91%) 5 (4.72%) 34 (10.40%)
J antiinfectives for systemic use N (%) 1,081 (44.27%) 28 (90.32%) 833 (54.98%) 56 (52.83%) 185 (56.57%)
G genito urinary system and sex hormones N (%) 639 (26.17%) 13 (41.94%) 346 (22.84%) 39 (36.79%) 83 (25.38%)
M musculo skeletal system N (%) 933 (38.21%) 20 (64.52%) 646 (42.64%) 35 (33.02%) 199 (60.86%)
V various N (%) 332 (13.60%) 9 (29.03%) 180 (11.88%) 12 (11.32%) 34 (10.40%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 590 (24.16%) 25 (80.65%) 377 (24.88%) 30 (28.30%) 114 (34.86%)
L antineoplastic and immunomodulating agents N (%) 127 (5.20%) - 80 (5.28%) 5 (4.72%) 32 (9.79%)
C cardiovascular system N (%) 2,063 (84.48%) 28 (90.32%) 1,294 (85.41%) 102 (96.23%) 283 (86.54%)
Conditions any time prior Diseases of the nervous system N (%) 620 (25.39%) 9 (29.03%) 377 (24.88%) 37 (34.91%) 106 (32.42%)
Certain conditions originating in the perinatal period N (%) 137 (5.61%) - 74 (4.88%) 37 (34.91%) 17 (5.20%)
Certain infectious and parasitic diseases N (%) 1,272 (52.09%) 21 (67.74%) 806 (53.20%) 70 (66.04%) 186 (56.88%)
Mental and behavioural disorders N (%) 139 (5.69%) - 67 (4.42%) 8 (7.55%) 17 (5.20%)
Pregnancy childbirth and the puerperium N (%) 34 (1.39%) - 14 (0.92%) 0 (0.00%) 5 (1.53%)
Endocrine nutritional and metabolic diseases N (%) 230 (9.42%) 6 (19.35%) 113 (7.46%) 43 (40.57%) 26 (7.95%)
Neoplasms N (%) 208 (8.52%) - 128 (8.45%) 8 (7.55%) 37 (11.31%)
Diseases of the digestive system N (%) 364 (14.91%) 6 (19.35%) 245 (16.17%) 20 (18.87%) 62 (18.96%)
Diseases of the circulatory system N (%) 819 (33.54%) 21 (67.74%) 552 (36.44%) 58 (54.72%) 127 (38.84%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 2,378 (97.38%) 31 (100.00%) 1,480 (97.69%) 106 (100.00%) 320 (97.86%)
Diseases of the skin and subcutaneous tissue N (%) 654 (26.78%) 9 (29.03%) 398 (26.27%) 25 (23.58%) 102 (31.19%)
Injury poisoning and certain other consequences of external causes N (%) 1,218 (49.88%) 25 (80.65%) 798 (52.67%) 56 (52.83%) 187 (57.19%)
Diseases of the ear and mastoid process N (%) 146 (5.98%) 5 (16.13%) 85 (5.61%) 7 (6.60%) 26 (7.95%)
Diseases of the genitourinary system N (%) 433 (17.73%) 11 (35.48%) 265 (17.49%) 22 (20.75%) 61 (18.65%)
Diseases of the respiratory system N (%) 446 (18.26%) 19 (61.29%) 349 (23.04%) 26 (24.53%) 91 (27.83%)
Congenital malformations deformations and chromosomal abnormalities N (%) 8 (0.33%) 0 (0.00%) 11 (0.73%) - -
Codes for special purposes N (%) 663 (27.15%) 14 (45.16%) 407 (26.86%) 47 (44.34%) 87 (26.61%)
Diseases of the musculoskeletal system and connective tissue N (%) 930 (38.08%) 11 (35.48%) 608 (40.13%) 41 (38.68%) 155 (47.40%)
Diseases of the eye and adnexa N (%) 382 (15.64%) - 250 (16.50%) 33 (31.13%) 48 (14.68%)
Factors influencing health status and contact with health services N (%) 2,381 (97.50%) 31 (100.00%) 1,484 (97.95%) 106 (100.00%) 322 (98.47%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 261 (10.69%) 11 (35.48%) 167 (11.02%) 14 (13.21%) 49 (14.98%)
External causes of morbidity and mortality N (%) 159 (6.51%) 11 (35.48%) 108 (7.13%) 10 (9.43%) 33 (10.09%)
overall Female Number records - N 17,311 343 9,486 662 2,380
Number subjects - N 10,876 325 6,686 611 1,962
Cohort start date - Median [Q25 - Q75] 2013-10-25 [2011-11-18 - 2016-03-16] 2014-02-18 [2012-03-06 - 2016-10-30] 2014-02-01 [2012-01-06 - 2016-06-27] 2013-12-27 [2012-02-29 - 2016-09-10] 2013-07-15 [2011-10-13 - 2015-11-25]
Range 2010-01-01 to 2019-12-31 2010-01-06 to 2019-12-03 2010-01-04 to 2019-12-31 2010-01-06 to 2019-12-20 2010-01-05 to 2019-12-30
Cohort end date - Median [Q25 - Q75] 2013-11-03 [2011-11-24 - 2016-03-22] 2014-03-04 [2012-03-14 - 2017-01-20] 2014-03-11 [2012-02-08 - 2016-08-07] 2015-04-23 [2012-12-26 - 2018-01-23] 2013-09-24 [2011-12-20 - 2016-03-21]
Range 2010-01-07 to 2020-01-23 2010-01-08 to 2024-06-09 2010-01-07 to 2024-06-09 2010-02-25 to 2024-06-10 2010-01-17 to 2024-06-09
Age - Median [Q25 - Q75] 45 [24 - 65] 29 [21 - 58] 52 [37 - 68] 58 [43 - 70] 55 [41 - 69]
Mean (SD) 44.28 (25.46) 37.80 (23.08) 52.56 (19.84) 56.69 (17.50) 54.99 (17.84)
Range 1 to 112 1 to 96 2 to 106 13 to 98 14 to 102
Age group 0 to 19 N (%) 3,509 (20.27%) 71 (20.70%) 335 (3.53%) 8 (1.21%) 20 (0.84%)
20 to 39 N (%) 3,859 (22.29%) 140 (40.82%) 2,384 (25.13%) 128 (19.34%) 496 (20.84%)
40 to 59 N (%) 4,514 (26.08%) 49 (14.29%) 3,171 (33.43%) 204 (30.82%) 880 (36.97%)
60 to 79 N (%) 3,883 (22.43%) 68 (19.83%) 2,604 (27.45%) 268 (40.48%) 758 (31.85%)
80 to 150 N (%) 1,546 (8.93%) 15 (4.37%) 992 (10.46%) 54 (8.16%) 226 (9.50%)
Sex Female N (%) 17,311 (100.00%) 343 (100.00%) 9,486 (100.00%) 662 (100.00%) 2,380 (100.00%)
Prior observation - Median [Q25 - Q75] 3,499 [1,764 - 5,002] 3,598 [2,134 - 4,960] 3,908 [2,376 - 5,311] 3,566 [1,567 - 5,178] 3,788 [2,428 - 5,127]
Mean (SD) 3,563.78 (2,133.80) 3,574.67 (1,908.41) 3,915.00 (2,103.47) 3,572.27 (2,194.56) 3,822.07 (2,013.20)
Range 365 to 10,993 380 to 9,291 365 to 10,983 365 to 10,971 365 to 10,644
Future observation - Median [Q25 - Q75] 1,881 [848 - 3,167] 1,923 [767 - 3,284] 1,962 [871 - 3,201] 1,634 [691 - 2,742] 1,941 [886 - 3,241]
Mean (SD) 2,088.59 (1,434.32) 2,072.31 (1,437.51) 2,123.40 (1,429.68) 1,862.31 (1,368.97) 2,139.04 (1,444.07)
Range 1 to 5,269 15 to 5,218 1 to 5,270 7 to 5,263 3 to 5,267
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 3 [1 - 6] 13 [8 - 28] 171 [56 - 620] 28 [21 - 43]
Mean (SD) 7.78 (9.70) 59.27 (270.94) 39.85 (160.43) 480.42 (701.88) 90.99 (296.85)
Range 1 to 645 1 to 2,919 1 to 5,099 7 to 4,747 1 to 4,168
Number of visits in the year prior - Median [Q25 - Q75] 15.00 [7.00 - 27.00] 17.00 [8.00 - 34.00] 19.00 [10.00 - 31.00] 28.00 [17.00 - 40.00] 27.00 [16.00 - 39.00]
Mean (SD) 19.52 (17.70) 24.07 (22.00) 22.73 (17.75) 31.19 (20.91) 30.40 (20.38)
Range 0.00 to 207.00 0.00 to 137.00 0.00 to 156.00 0.00 to 191.00 0.00 to 161.00
Medications in the year prior D dermatologicals N (%) 5,835 (33.71%) 136 (39.65%) 3,318 (34.98%) 276 (41.69%) 994 (41.76%)
N nervous system N (%) 8,742 (50.50%) 177 (51.60%) 5,462 (57.58%) 455 (68.73%) 1,998 (83.95%)
R respiratory system N (%) 6,532 (37.73%) 177 (51.60%) 3,775 (39.80%) 289 (43.66%) 1,288 (54.12%)
S sensory organs N (%) 2,344 (13.54%) 53 (15.45%) 1,275 (13.44%) 100 (15.11%) 365 (15.34%)
A alimentary tract and metabolism N (%) 7,633 (44.09%) 162 (47.23%) 4,991 (52.61%) 422 (63.75%) 1,632 (68.57%)
B blood and blood forming organs N (%) 3,417 (19.74%) 86 (25.07%) 2,287 (24.11%) 191 (28.85%) 739 (31.05%)
P antiparasitic products insecticides and repellents N (%) 984 (5.68%) 50 (14.58%) 644 (6.79%) 48 (7.25%) 242 (10.17%)
J antiinfectives for systemic use N (%) 7,259 (41.93%) 259 (75.51%) 5,096 (53.72%) 380 (57.40%) 1,381 (58.03%)
G genito urinary system and sex hormones N (%) 4,967 (28.69%) 160 (46.65%) 3,019 (31.83%) 194 (29.31%) 785 (32.98%)
M musculo skeletal system N (%) 4,710 (27.21%) 99 (28.86%) 3,435 (36.21%) 231 (34.89%) 1,350 (56.72%)
V various N (%) 1,186 (6.85%) 29 (8.45%) 736 (7.76%) 64 (9.67%) 217 (9.12%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 2,496 (14.42%) 91 (26.53%) 1,790 (18.87%) 154 (23.26%) 655 (27.52%)
L antineoplastic and immunomodulating agents N (%) 748 (4.32%) 20 (5.83%) 469 (4.94%) 32 (4.83%) 189 (7.94%)
C cardiovascular system N (%) 6,563 (37.91%) 118 (34.40%) 4,258 (44.89%) 421 (63.60%) 1,295 (54.41%)
Conditions any time prior Diseases of the nervous system N (%) 3,723 (21.51%) 79 (23.03%) 2,321 (24.47%) 173 (26.13%) 766 (32.18%)
Certain conditions originating in the perinatal period N (%) 416 (2.40%) 9 (2.62%) 315 (3.32%) 205 (30.97%) 90 (3.78%)
Certain infectious and parasitic diseases N (%) 7,927 (45.79%) 175 (51.02%) 4,368 (46.05%) 391 (59.06%) 1,189 (49.96%)
Mental and behavioural disorders N (%) 801 (4.63%) 18 (5.25%) 584 (6.16%) 39 (5.89%) 187 (7.86%)
Pregnancy childbirth and the puerperium N (%) 995 (5.75%) 30 (8.75%) 583 (6.15%) 64 (9.67%) 122 (5.13%)
Endocrine nutritional and metabolic diseases N (%) 925 (5.34%) 19 (5.54%) 641 (6.76%) 257 (38.82%) 197 (8.28%)
Neoplasms N (%) 769 (4.44%) 13 (3.79%) 478 (5.04%) 32 (4.83%) 136 (5.71%)
Diseases of the digestive system N (%) 2,480 (14.33%) 66 (19.24%) 1,428 (15.05%) 89 (13.44%) 463 (19.45%)
Diseases of the circulatory system N (%) 4,813 (27.80%) 148 (43.15%) 2,881 (30.37%) 346 (52.27%) 836 (35.13%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 15,193 (87.77%) 321 (93.59%) 8,794 (92.71%) 654 (98.79%) 2,294 (96.39%)
Diseases of the skin and subcutaneous tissue N (%) 4,331 (25.02%) 97 (28.28%) 2,378 (25.07%) 176 (26.59%) 697 (29.29%)
Injury poisoning and certain other consequences of external causes N (%) 6,875 (39.71%) 178 (51.90%) 4,166 (43.92%) 296 (44.71%) 1,199 (50.38%)
Diseases of the ear and mastoid process N (%) 1,013 (5.85%) 17 (4.96%) 583 (6.15%) 51 (7.70%) 163 (6.85%)
Diseases of the genitourinary system N (%) 2,456 (14.19%) 73 (21.28%) 1,555 (16.39%) 148 (22.36%) 431 (18.11%)
Diseases of the respiratory system N (%) 3,012 (17.40%) 119 (34.69%) 1,970 (20.77%) 160 (24.17%) 593 (24.92%)
Congenital malformations deformations and chromosomal abnormalities N (%) 76 (0.44%) - 38 (0.40%) - 13 (0.55%)
Codes for special purposes N (%) 2,413 (13.94%) 57 (16.62%) 1,694 (17.86%) 156 (23.56%) 542 (22.77%)
Diseases of the musculoskeletal system and connective tissue N (%) 5,831 (33.68%) 139 (40.52%) 3,380 (35.63%) 240 (36.25%) 1,057 (44.41%)
Diseases of the eye and adnexa N (%) 1,531 (8.84%) 29 (8.45%) 832 (8.77%) 144 (21.75%) 213 (8.95%)
Factors influencing health status and contact with health services N (%) 15,329 (88.55%) 329 (95.92%) 8,843 (93.22%) 651 (98.34%) 2,313 (97.18%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 1,439 (8.31%) 46 (13.41%) 914 (9.64%) 55 (8.31%) 269 (11.30%)
External causes of morbidity and mortality N (%) 532 (3.07%) 20 (5.83%) 457 (4.82%) 30 (4.53%) 164 (6.89%)
Male Number records - N 12,822 225 6,584 735 1,573
Number subjects - N 8,581 205 4,809 686 1,327
Cohort start date - Median [Q25 - Q75] 2013-10-08 [2011-11-22 - 2016-02-26] 2014-01-15 [2012-01-19 - 2016-11-25] 2014-02-25 [2012-01-06 - 2016-09-02] 2013-11-26 [2011-12-21 - 2016-08-23] 2013-07-05 [2011-09-13 - 2015-09-03]
Range 2010-01-04 to 2019-12-31 2010-02-01 to 2019-11-29 2010-01-04 to 2019-12-30 2010-01-04 to 2019-12-17 2010-01-04 to 2019-12-13
Cohort end date - Median [Q25 - Q75] 2013-10-14 [2011-11-28 - 2016-03-03] 2014-05-15 [2012-03-28 - 2017-04-05] 2014-04-02 [2012-02-08 - 2016-10-12] 2015-07-30 [2013-05-18 - 2018-07-31] 2013-09-18 [2011-11-29 - 2015-12-13]
Range 2010-01-08 to 2020-01-22 2010-02-01 to 2024-03-03 2010-01-09 to 2024-06-09 2010-02-26 to 2024-06-09 2010-01-17 to 2024-06-06
Age - Median [Q25 - Q75] 45 [15 - 64] 31 [21 - 62] 54 [40 - 68] 60 [51 - 70] 56 [44 - 68]
Mean (SD) 41.65 (26.82) 38.72 (25.03) 53.45 (18.48) 59.52 (13.52) 55.34 (16.66)
Range 1 to 106 1 to 90 2 to 105 10 to 92 15 to 95
Age group 0 to 19 N (%) 3,646 (28.44%) 47 (20.89%) 186 (2.83%) - 9 (0.57%)
20 to 39 N (%) 2,056 (16.03%) 85 (37.78%) 1,429 (21.70%) 52 (7.07%) 281 (17.86%)
40 to 59 N (%) 3,110 (24.26%) 29 (12.89%) 2,369 (35.98%) 306 (41.63%) 620 (39.42%)
60 to 79 N (%) 3,114 (24.29%) 48 (21.33%) 2,077 (31.55%) 323 (43.95%) 562 (35.73%)
80 to 150 N (%) 896 (6.99%) 16 (7.11%) 523 (7.94%) 52 (7.07%) 101 (6.42%)
Sex Male N (%) 12,822 (100.00%) 225 (100.00%) 6,584 (100.00%) 735 (100.00%) 1,573 (100.00%)
Prior observation - Median [Q25 - Q75] 3,302 [1,586 - 4,867] 3,688 [2,259 - 5,353] 3,937 [2,362 - 5,354] 3,545 [1,598 - 5,140] 3,730 [2,294 - 5,097]
Mean (SD) 3,422.59 (2,140.23) 3,702.67 (2,016.22) 3,953.75 (2,148.59) 3,631.15 (2,314.68) 3,799.20 (2,087.93)
Range 365 to 11,197 378 to 9,486 365 to 11,385 370 to 10,781 367 to 10,576
Future observation - Median [Q25 - Q75] 1,899 [833 - 3,180] 1,931 [837 - 2,867] 1,928 [840 - 3,119] 1,796 [806 - 2,916] 1,893 [783 - 3,203]
Mean (SD) 2,091.62 (1,439.78) 2,043.30 (1,374.19) 2,083.21 (1,424.02) 1,952.90 (1,337.85) 2,063.29 (1,455.43)
Range 0 to 5,271 16 to 5,059 0 to 5,270 7 to 5,241 1 to 5,267
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 3 [1 - 8] 13 [8 - 28] 242 [65 - 798] 28 [28 - 51]
Mean (SD) 7.60 (5.52) 84.05 (310.49) 37.10 (153.77) 645.65 (911.58) 91.93 (287.06)
Range 1 to 128 1 to 2,149 1 to 3,562 8 to 5,001 2 to 4,700
Number of visits in the year prior - Median [Q25 - Q75] 11.00 [4.00 - 24.00] 13.00 [4.00 - 36.00] 16.00 [6.00 - 29.00] 24.00 [15.00 - 35.00] 23.00 [11.00 - 38.00]
Mean (SD) 16.94 (17.79) 24.47 (27.99) 20.18 (18.64) 27.01 (17.64) 26.98 (22.02)
Range 0.00 to 310.00 0.00 to 171.00 0.00 to 144.00 0.00 to 129.00 0.00 to 312.00
Medications in the year prior D dermatologicals N (%) 3,926 (30.62%) 87 (38.67%) 1,940 (29.47%) 248 (33.74%) 563 (35.79%)
N nervous system N (%) 5,164 (40.27%) 106 (47.11%) 3,139 (47.68%) 452 (61.50%) 1,206 (76.67%)
R respiratory system N (%) 4,372 (34.10%) 106 (47.11%) 2,145 (32.58%) 245 (33.33%) 673 (42.78%)
S sensory organs N (%) 1,565 (12.21%) 27 (12.00%) 683 (10.37%) 87 (11.84%) 205 (13.03%)
A alimentary tract and metabolism N (%) 4,932 (38.47%) 95 (42.22%) 2,975 (45.19%) 449 (61.09%) 955 (60.71%)
B blood and blood forming organs N (%) 1,859 (14.50%) 42 (18.67%) 1,277 (19.40%) 154 (20.95%) 405 (25.75%)
P antiparasitic products insecticides and repellents N (%) 441 (3.44%) 11 (4.89%) 241 (3.66%) 28 (3.81%) 93 (5.91%)
J antiinfectives for systemic use N (%) 3,887 (30.32%) 141 (62.67%) 2,506 (38.06%) 272 (37.01%) 702 (44.63%)
G genito urinary system and sex hormones N (%) 1,934 (15.08%) 45 (20.00%) 1,215 (18.45%) 197 (26.80%) 363 (23.08%)
M musculo skeletal system N (%) 2,723 (21.24%) 56 (24.89%) 2,100 (31.90%) 206 (28.03%) 786 (49.97%)
V various N (%) 506 (3.95%) 13 (5.78%) 285 (4.33%) 36 (4.90%) 99 (6.29%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 1,066 (8.31%) 62 (27.56%) 674 (10.24%) 94 (12.79%) 223 (14.18%)
L antineoplastic and immunomodulating agents N (%) 282 (2.20%) - 192 (2.92%) 22 (2.99%) 78 (4.96%)
C cardiovascular system N (%) 4,932 (38.47%) 71 (31.56%) 3,074 (46.69%) 531 (72.24%) 832 (52.89%)
Conditions any time prior Diseases of the nervous system N (%) 2,234 (17.42%) 46 (20.44%) 1,264 (19.20%) 127 (17.28%) 429 (27.27%)
Certain conditions originating in the perinatal period N (%) 433 (3.38%) 10 (4.44%) 301 (4.57%) 234 (31.84%) 89 (5.66%)
Certain infectious and parasitic diseases N (%) 5,335 (41.61%) 100 (44.44%) 2,655 (40.33%) 392 (53.33%) 733 (46.60%)
Mental and behavioural disorders N (%) 397 (3.10%) 12 (5.33%) 284 (4.31%) 26 (3.54%) 87 (5.53%)
Pregnancy childbirth and the puerperium N (%) 39 (0.30%) 0 (0.00%) 23 (0.35%) - 10 (0.64%)
Endocrine nutritional and metabolic diseases N (%) 639 (4.98%) 11 (4.89%) 471 (7.15%) 280 (38.10%) 145 (9.22%)
Neoplasms N (%) 509 (3.97%) 6 (2.67%) 375 (5.70%) 49 (6.67%) 123 (7.82%)
Diseases of the digestive system N (%) 1,611 (12.56%) 41 (18.22%) 815 (12.38%) 95 (12.93%) 254 (16.15%)
Diseases of the circulatory system N (%) 3,420 (26.67%) 85 (37.78%) 1,675 (25.44%) 370 (50.34%) 473 (30.07%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 10,347 (80.70%) 183 (81.33%) 5,644 (85.72%) 722 (98.23%) 1,453 (92.37%)
Diseases of the skin and subcutaneous tissue N (%) 3,083 (24.04%) 56 (24.89%) 1,525 (23.16%) 164 (22.31%) 440 (27.97%)
Injury poisoning and certain other consequences of external causes N (%) 4,465 (34.82%) 97 (43.11%) 2,436 (37.00%) 290 (39.46%) 705 (44.82%)
Diseases of the ear and mastoid process N (%) 714 (5.57%) 17 (7.56%) 357 (5.42%) 41 (5.58%) 96 (6.10%)
Diseases of the genitourinary system N (%) 842 (6.57%) 21 (9.33%) 470 (7.14%) 75 (10.20%) 157 (9.98%)
Diseases of the respiratory system N (%) 2,353 (18.35%) 82 (36.44%) 1,110 (16.86%) 136 (18.50%) 330 (20.98%)
Congenital malformations deformations and chromosomal abnormalities N (%) 109 (0.85%) - 54 (0.82%) - 15 (0.95%)
Codes for special purposes N (%) 2,151 (16.78%) 49 (21.78%) 1,418 (21.54%) 242 (32.93%) 384 (24.41%)
Diseases of the musculoskeletal system and connective tissue N (%) 4,009 (31.27%) 61 (27.11%) 2,204 (33.48%) 230 (31.29%) 675 (42.91%)
Diseases of the eye and adnexa N (%) 1,129 (8.81%) 15 (6.67%) 586 (8.90%) 160 (21.77%) 176 (11.19%)
Factors influencing health status and contact with health services N (%) 10,451 (81.51%) 190 (84.44%) 5,681 (86.28%) 723 (98.37%) 1,484 (94.34%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 868 (6.77%) 22 (9.78%) 447 (6.79%) 59 (8.03%) 137 (8.71%)
External causes of morbidity and mortality N (%) 261 (2.04%) 14 (6.22%) 207 (3.14%) 36 (4.90%) 77 (4.90%)
0 to 19 Female Number records - N 3,509 71 335 8 20
Number subjects - N 2,500 70 289 8 19
Cohort start date - Median [Q25 - Q75] 2013-08-13 [2011-11-14 - 2016-01-08] 2013-06-17 [2011-09-07 - 2015-10-22] 2013-06-20 [2011-08-31 - 2016-03-01] 2013-01-16 [2011-05-11 - 2016-05-08] 2012-10-09 [2011-04-17 - 2013-05-08]
Range 2010-01-04 to 2019-12-31 2010-01-06 to 2019-02-04 2010-01-11 to 2019-12-19 2010-10-15 to 2018-10-05 2010-02-19 to 2018-05-17
Cohort end date - Median [Q25 - Q75] 2013-08-20 [2011-11-21 - 2016-01-17] 2013-06-27 [2011-09-08 - 2015-10-22] 2013-07-05 [2011-09-13 - 2016-03-26] 2013-02-26 [2011-06-07 - 2016-09-13] 2012-10-17 [2011-05-09 - 2013-06-08]
Range 2010-01-08 to 2020-01-06 2010-01-08 to 2024-01-22 2010-01-14 to 2020-11-22 2010-11-11 to 2018-12-23 2010-07-19 to 2018-08-20
Age - Median [Q25 - Q75] 6 [3 - 13] 16 [4 - 18] 17 [15 - 18] 17 [15 - 18] 19 [18 - 19]
Mean (SD) 7.83 (5.78) 12.17 (6.80) 16.63 (2.50) 16.50 (2.00) 18.00 (1.45)
Range 1 to 19 1 to 19 2 to 19 13 to 19 14 to 19
Age group 0 to 19 N (%) 3,509 (100.00%) 71 (100.00%) 335 (100.00%) 8 (100.00%) 20 (100.00%)
Sex Female N (%) 3,509 (100.00%) 71 (100.00%) 335 (100.00%) 8 (100.00%) 20 (100.00%)
Prior observation - Median [Q25 - Q75] 1,730 [820 - 3,176] 2,689 [1,625 - 3,689] 4,049 [2,611 - 5,066] 4,916 [3,821 - 5,012] 3,456 [2,709 - 4,675]
Mean (SD) 2,128.40 (1,525.97) 2,773.42 (1,501.82) 3,787.10 (1,653.21) 4,331.38 (1,579.33) 3,560.40 (1,682.95)
Range 365 to 7,043 446 to 7,215 403 to 7,183 1,122 to 6,328 412 to 7,102
Future observation - Median [Q25 - Q75] 1,968 [892 - 3,301] 2,072 [1,038 - 3,358] 1,949 [1,006 - 3,236] 370 [262 - 1,324] 2,730 [1,250 - 4,223]
Mean (SD) 2,158.62 (1,450.71) 2,245.89 (1,439.65) 2,195.70 (1,440.98) 1,076.62 (1,415.00) 2,688.45 (1,675.37)
Range 4 to 5,267 47 to 4,947 6 to 5,263 81 to 4,090 95 to 5,008
Days in cohort - Median [Q25 - Q75] 7 [5 - 7] 3 [1 - 3] 13 [7 - 28] 42 [28 - 62] 28 [9 - 28]
Mean (SD) 7.30 (5.68) 47.59 (346.19) 27.84 (134.65) 57.12 (43.28) 32.80 (38.69)
Range 1 to 141 1 to 2,919 1 to 2,173 28 to 153 4 to 167
Number of visits in the year prior - Median [Q25 - Q75] 6.00 [3.00 - 10.00] 11.00 [5.00 - 19.00] 10.00 [5.00 - 15.00] 8.50 [6.25 - 15.25] 15.50 [12.75 - 26.75]
Mean (SD) 7.84 (7.71) 14.00 (11.82) 11.57 (8.87) 12.62 (12.98) 18.55 (10.76)
Range 0.00 to 86.00 1.00 to 53.00 0.00 to 71.00 0.00 to 42.00 0.00 to 39.00
Medications in the year prior D dermatologicals N (%) 1,080 (30.78%) 25 (35.21%) 123 (36.72%) - 10 (50.00%)
N nervous system N (%) 574 (16.36%) 20 (28.17%) 96 (28.66%) - 13 (65.00%)
R respiratory system N (%) 1,069 (30.46%) 30 (42.25%) 142 (42.39%) 0 (0.00%) 16 (80.00%)
S sensory organs N (%) 447 (12.74%) 10 (14.08%) 38 (11.34%) 0 (0.00%) -
A alimentary tract and metabolism N (%) 706 (20.12%) 19 (26.76%) 80 (23.88%) - 5 (25.00%)
B blood and blood forming organs N (%) 149 (4.25%) 9 (12.68%) 72 (21.49%) 0 (0.00%) 8 (40.00%)
P antiparasitic products insecticides and repellents N (%) 96 (2.74%) 8 (11.27%) 18 (5.37%) 0 (0.00%) 5 (25.00%)
J antiinfectives for systemic use N (%) 1,533 (43.69%) 54 (76.06%) 198 (59.10%) - 16 (80.00%)
G genito urinary system and sex hormones N (%) 501 (14.28%) 29 (40.85%) 156 (46.57%) - 10 (50.00%)
M musculo skeletal system N (%) 377 (10.74%) 11 (15.49%) 106 (31.64%) 0 (0.00%) 12 (60.00%)
V various N (%) 43 (1.23%) 0 (0.00%) 20 (5.97%) - 0 (0.00%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 113 (3.22%) 6 (8.45%) 14 (4.18%) 0 (0.00%) 0 (0.00%)
L antineoplastic and immunomodulating agents N (%) 38 (1.08%) - 23 (6.87%) 0 (0.00%) -
C cardiovascular system N (%) 448 (12.77%) 13 (18.31%) 43 (12.84%) 0 (0.00%) -
Conditions any time prior Diseases of the nervous system N (%) 698 (19.89%) 15 (21.13%) 92 (27.46%) - 8 (40.00%)
Certain conditions originating in the perinatal period N (%) 8 (0.23%) - - 0 (0.00%) 0 (0.00%)
Certain infectious and parasitic diseases N (%) 1,666 (47.48%) 34 (47.89%) 172 (51.34%) - 14 (70.00%)
Mental and behavioural disorders N (%) 29 (0.83%) - 12 (3.58%) 0 (0.00%) -
Pregnancy childbirth and the puerperium N (%) 52 (1.48%) - 17 (5.07%) 0 (0.00%) 0 (0.00%)
Endocrine nutritional and metabolic diseases N (%) 24 (0.68%) - 12 (3.58%) - -
Neoplasms N (%) 26 (0.74%) - - 0 (0.00%) 0 (0.00%)
Diseases of the digestive system N (%) 593 (16.90%) 16 (22.54%) 59 (17.61%) 0 (0.00%) -
Diseases of the circulatory system N (%) 1,173 (33.43%) 24 (33.80%) 101 (30.15%) - 11 (55.00%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 2,578 (73.47%) 63 (88.73%) 297 (88.66%) 7 (87.50%) 18 (90.00%)
Diseases of the skin and subcutaneous tissue N (%) 955 (27.22%) 19 (26.76%) 82 (24.48%) - 9 (45.00%)
Injury poisoning and certain other consequences of external causes N (%) 1,285 (36.62%) 32 (45.07%) 162 (48.36%) - 13 (65.00%)
Diseases of the ear and mastoid process N (%) 234 (6.67%) - 26 (7.76%) - -
Diseases of the genitourinary system N (%) 202 (5.76%) 12 (16.90%) 45 (13.43%) - 5 (25.00%)
Diseases of the respiratory system N (%) 936 (26.67%) 24 (33.80%) 64 (19.10%) 0 (0.00%) 6 (30.00%)
Congenital malformations deformations and chromosomal abnormalities N (%) 24 (0.68%) - 0 (0.00%) 0 (0.00%) 0 (0.00%)
Codes for special purposes N (%) 108 (3.08%) 5 (7.04%) 27 (8.06%) - 0 (0.00%)
Diseases of the musculoskeletal system and connective tissue N (%) 1,140 (32.49%) 26 (36.62%) 112 (33.43%) - 11 (55.00%)
Diseases of the eye and adnexa N (%) 267 (7.61%) 7 (9.86%) 25 (7.46%) - -
Factors influencing health status and contact with health services N (%) 2,695 (76.80%) 65 (91.55%) 290 (86.57%) 7 (87.50%) 19 (95.00%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 309 (8.81%) 11 (15.49%) 37 (11.04%) 0 (0.00%) -
External causes of morbidity and mortality N (%) 21 (0.60%) - 6 (1.79%) 0 (0.00%) -
Male Number records - N 3,646 47 186 - 9
Number subjects - N 2,580 44 174 - 9
Cohort start date - Median [Q25 - Q75] 2013-09-26 [2011-11-28 - 2015-12-09] 2013-08-16 [2011-10-21 - 2017-04-12] 2013-08-09 [2011-10-14 - 2015-10-12] - 2012-09-14 [2011-11-07 - 2013-04-11]
Range 2010-01-04 to 2019-12-31 2010-07-29 to 2019-07-01 2010-01-15 to 2019-11-15 - 2011-02-25 to 2015-02-09
Cohort end date - Median [Q25 - Q75] 2013-10-02 [2011-12-04 - 2015-12-17] 2013-09-24 [2011-10-28 - 2017-04-14] 2013-08-18 [2011-10-19 - 2015-10-15] - 2012-09-17 [2011-11-29 - 2013-04-18]
Range 2010-01-08 to 2020-01-06 2010-07-31 to 2019-07-03 2010-02-04 to 2019-11-27 - 2011-03-24 to 2015-03-15
Age - Median [Q25 - Q75] 5 [2 - 11] 4 [2 - 17] 17 [15 - 19] - 18 [18 - 19]
Mean (SD) 7.06 (5.47) 8.23 (7.21) 16.47 (3.01) - 17.78 (1.64)
Range 1 to 19 1 to 19 2 to 19 - 15 to 19
Age group 0 to 19 N (%) 3,646 (100.00%) 47 (100.00%) 186 (100.00%) - 9 (100.00%)
Sex Male N (%) 3,646 (100.00%) 47 (100.00%) 186 (100.00%) - 9 (100.00%)
Prior observation - Median [Q25 - Q75] 1,588 [746 - 2,966] 1,463 [756 - 2,864] 3,608 [2,387 - 4,946] - 3,988 [3,441 - 4,547]
Mean (SD) 2,009.77 (1,487.43) 2,255.13 (1,960.77) 3,597.30 (1,807.50) - 3,795.44 (1,371.77)
Range 365 to 7,065 378 to 7,217 373 to 7,012 - 949 to 5,586
Future observation - Median [Q25 - Q75] 2,030 [950 - 3,415] 2,166 [1,154 - 3,366] 2,346 [909 - 3,514] - 2,157 [739 - 4,406]
Mean (SD) 2,225.57 (1,463.93) 2,254.98 (1,453.73) 2,377.38 (1,533.75) - 2,478.56 (1,839.72)
Range 1 to 5,271 30 to 5,059 7 to 5,248 - 212 to 4,741
Days in cohort - Median [Q25 - Q75] 7 [5 - 7] 3 [3 - 3] 13 [6 - 28] - 23 [8 - 28]
Mean (SD) 7.46 (5.86) 18.45 (57.46) 19.75 (54.48) - 18.44 (12.27)
Range 1 to 90 1 to 341 2 to 743 - 4 to 35
Number of visits in the year prior - Median [Q25 - Q75] 6.00 [3.00 - 11.00] 11.00 [6.00 - 23.50] 6.00 [2.00 - 13.00] 7.50 [7.25 - 7.75] 11.00 [7.00 - 14.00]
Mean (SD) 8.38 (9.13) 20.66 (25.46) 8.88 (10.55) 7.50 (0.71) 13.00 (10.15)
Range 0.00 to 107.00 0.00 to 118.00 0.00 to 110.00 7.00 to 8.00 3.00 to 38.00
Medications in the year prior D dermatologicals N (%) 1,081 (29.65%) 21 (44.68%) 50 (26.88%) 0 (0.00%) -
N nervous system N (%) 582 (15.96%) 16 (34.04%) 34 (18.28%) 0 (0.00%) -
R respiratory system N (%) 1,180 (32.36%) 25 (53.19%) 76 (40.86%) - -
S sensory organs N (%) 511 (14.02%) 10 (21.28%) 12 (6.45%) 0 (0.00%) -
A alimentary tract and metabolism N (%) 728 (19.97%) 15 (31.91%) 29 (15.59%) 0 (0.00%) -
B blood and blood forming organs N (%) 105 (2.88%) - 15 (8.06%) 0 (0.00%) -
P antiparasitic products insecticides and repellents N (%) 92 (2.52%) 0 (0.00%) - 0 (0.00%) 0 (0.00%)
J antiinfectives for systemic use N (%) 1,435 (39.36%) 39 (82.98%) 77 (41.40%) 0 (0.00%) 5 (55.56%)
G genito urinary system and sex hormones N (%) 198 (5.43%) 7 (14.89%) 7 (3.76%) 0 (0.00%) 0 (0.00%)
M musculo skeletal system N (%) 254 (6.97%) 11 (23.40%) 38 (20.43%) 0 (0.00%) 5 (55.56%)
V various N (%) 48 (1.32%) - 6 (3.23%) 0 (0.00%) 0 (0.00%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 177 (4.85%) 5 (10.64%) 8 (4.30%) 0 (0.00%) 0 (0.00%)
L antineoplastic and immunomodulating agents N (%) 6 (0.16%) 0 (0.00%) - 0 (0.00%) 0 (0.00%)
C cardiovascular system N (%) 511 (14.02%) 10 (21.28%) 20 (10.75%) 0 (0.00%) -
Conditions any time prior Diseases of the nervous system N (%) 711 (19.50%) 20 (42.55%) 37 (19.89%) 0 (0.00%) -
Certain conditions originating in the perinatal period N (%) 11 (0.30%) 0 (0.00%) 0 (0.00%) - 0 (0.00%)
Certain infectious and parasitic diseases N (%) 1,741 (47.75%) 30 (63.83%) 82 (44.09%) 0 (0.00%) -
Mental and behavioural disorders N (%) 39 (1.07%) - - 0 (0.00%) 0 (0.00%)
Pregnancy childbirth and the puerperium N (%) 13 (0.36%) 0 (0.00%) - 0 (0.00%) 0 (0.00%)
Endocrine nutritional and metabolic diseases N (%) 17 (0.47%) 0 (0.00%) 0 (0.00%) - 0 (0.00%)
Neoplasms N (%) 23 (0.63%) - - 0 (0.00%) 0 (0.00%)
Diseases of the digestive system N (%) 608 (16.68%) 15 (31.91%) 25 (13.44%) 0 (0.00%) -
Diseases of the circulatory system N (%) 1,275 (34.97%) 28 (59.57%) 36 (19.35%) - -
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 2,649 (72.65%) 41 (87.23%) 144 (77.42%) - 8 (88.89%)
Diseases of the skin and subcutaneous tissue N (%) 1,005 (27.56%) 20 (42.55%) 48 (25.81%) 0 (0.00%) -
Injury poisoning and certain other consequences of external causes N (%) 1,333 (36.56%) 24 (51.06%) 75 (40.32%) 0 (0.00%) 7 (77.78%)
Diseases of the ear and mastoid process N (%) 260 (7.13%) 8 (17.02%) 7 (3.76%) 0 (0.00%) 0 (0.00%)
Diseases of the genitourinary system N (%) 122 (3.35%) - - 0 (0.00%) 0 (0.00%)
Diseases of the respiratory system N (%) 1,080 (29.62%) 28 (59.57%) 39 (20.97%) 0 (0.00%) -
Congenital malformations deformations and chromosomal abnormalities N (%) 53 (1.45%) - - 0 (0.00%) 0 (0.00%)
Codes for special purposes N (%) 100 (2.74%) - 9 (4.84%) 0 (0.00%) -
Diseases of the musculoskeletal system and connective tissue N (%) 1,228 (33.68%) 20 (42.55%) 68 (36.56%) 0 (0.00%) 6 (66.67%)
Diseases of the eye and adnexa N (%) 286 (7.84%) 6 (12.77%) 7 (3.76%) 0 (0.00%) 0 (0.00%)
Factors influencing health status and contact with health services N (%) 2,739 (75.12%) 41 (87.23%) 139 (74.73%) - 9 (100.00%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 284 (7.79%) 6 (12.77%) 19 (10.22%) 0 (0.00%) -
External causes of morbidity and mortality N (%) 14 (0.38%) - 0 (0.00%) 0 (0.00%) -
20 to 39 Female Number records - N 3,859 140 2,384 128 496
Number subjects - N 2,725 138 1,789 113 415
Cohort start date - Median [Q25 - Q75] 2013-09-23 [2011-10-19 - 2016-02-29] 2014-03-31 [2011-12-12 - 2016-09-14] 2014-03-12 [2012-01-20 - 2016-07-27] 2014-07-01 [2012-10-23 - 2016-09-29] 2013-09-17 [2011-11-10 - 2016-07-02]
Range 2010-01-01 to 2019-12-31 2010-01-14 to 2019-12-03 2010-01-05 to 2019-12-30 2010-01-29 to 2019-12-02 2010-01-05 to 2019-12-24
Cohort end date - Median [Q25 - Q75] 2013-09-29 [2011-10-25 - 2016-03-06] 2014-05-30 [2012-02-09 - 2016-09-14] 2014-04-04 [2012-02-14 - 2016-08-13] 2014-12-15 [2013-01-11 - 2017-02-25] 2013-10-16 [2011-12-14 - 2016-08-22]
Range 2010-01-07 to 2020-01-12 2010-01-14 to 2019-12-12 2010-01-09 to 2024-06-09 2010-02-25 to 2024-06-09 2010-01-22 to 2024-06-09
Age - Median [Q25 - Q75] 30 [25 - 35] 26 [22 - 30] 30 [25 - 35] 33 [29 - 36] 31 [27 - 35]
Mean (SD) 29.80 (5.72) 26.56 (5.32) 30.02 (5.57) 31.95 (4.87) 30.96 (5.29)
Range 20 to 39 20 to 39 20 to 39 21 to 39 20 to 39
Age group 20 to 39 N (%) 3,859 (100.00%) 140 (100.00%) 2,384 (100.00%) 128 (100.00%) 496 (100.00%)
Sex Female N (%) 3,859 (100.00%) 140 (100.00%) 2,384 (100.00%) 128 (100.00%) 496 (100.00%)
Prior observation - Median [Q25 - Q75] 3,176 [1,510 - 4,727] 3,602 [1,859 - 4,974] 3,206 [1,500 - 4,882] 2,638 [1,233 - 4,707] 3,216 [1,587 - 4,828]
Mean (SD) 3,332.81 (2,079.57) 3,493.71 (2,021.05) 3,371.34 (2,084.83) 3,124.41 (2,205.42) 3,335.15 (2,011.81)
Range 365 to 10,993 423 to 9,235 365 to 10,546 371 to 10,971 371 to 9,679
Future observation - Median [Q25 - Q75] 1,834 [816 - 3,201] 1,975 [773 - 3,380] 2,079 [908 - 3,322] 1,480 [787 - 2,870] 2,082 [896 - 3,421]
Mean (SD) 2,081.41 (1,456.40) 2,142.86 (1,470.77) 2,197.92 (1,442.77) 1,858.58 (1,345.80) 2,199.41 (1,462.20)
Range 5 to 5,269 18 to 5,141 1 to 5,267 7 to 5,023 7 to 5,259
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 1 [1 - 3] 13 [7 - 28] 65 [28 - 146] 28 [15 - 30]
Mean (SD) 7.57 (5.32) 16.08 (124.93) 29.69 (148.18) 185.50 (404.10) 67.01 (214.41)
Range 1 to 72 1 to 1,427 1 to 3,880 8 to 3,313 2 to 2,219
Number of visits in the year prior - Median [Q25 - Q75] 11.00 [6.00 - 21.00] 11.00 [7.00 - 19.00] 13.00 [7.00 - 22.00] 18.00 [13.00 - 30.00] 20.00 [11.00 - 32.00]
Mean (SD) 15.26 (13.82) 14.18 (10.33) 16.10 (12.93) 23.58 (20.47) 23.53 (17.96)
Range 0.00 to 176.00 1.00 to 56.00 0.00 to 110.00 1.00 to 191.00 0.00 to 159.00
Medications in the year prior D dermatologicals N (%) 1,328 (34.41%) 54 (38.57%) 848 (35.57%) 49 (38.28%) 213 (42.94%)
N nervous system N (%) 1,653 (42.83%) 56 (40.00%) 1,057 (44.34%) 72 (56.25%) 369 (74.40%)
R respiratory system N (%) 1,323 (34.28%) 48 (34.29%) 853 (35.78%) 48 (37.50%) 267 (53.83%)
S sensory organs N (%) 360 (9.33%) 11 (7.86%) 201 (8.43%) 12 (9.38%) 56 (11.29%)
A alimentary tract and metabolism N (%) 1,191 (30.86%) 41 (29.29%) 850 (35.65%) 65 (50.78%) 259 (52.22%)
B blood and blood forming organs N (%) 833 (21.59%) 30 (21.43%) 578 (24.24%) 36 (28.12%) 155 (31.25%)
P antiparasitic products insecticides and repellents N (%) 231 (5.99%) 30 (21.43%) 171 (7.17%) 11 (8.59%) 51 (10.28%)
J antiinfectives for systemic use N (%) 1,696 (43.95%) 92 (65.71%) 1,322 (55.45%) 71 (55.47%) 298 (60.08%)
G genito urinary system and sex hormones N (%) 2,036 (52.76%) 89 (63.57%) 1,220 (51.17%) 52 (40.62%) 277 (55.85%)
M musculo skeletal system N (%) 891 (23.09%) 28 (20.00%) 709 (29.74%) 33 (25.78%) 264 (53.23%)
V various N (%) 345 (8.94%) 10 (7.14%) 227 (9.52%) 19 (14.84%) 46 (9.27%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 270 (7.00%) 10 (7.14%) 183 (7.68%) 10 (7.81%) 59 (11.90%)
L antineoplastic and immunomodulating agents N (%) 221 (5.73%) 11 (7.86%) 153 (6.42%) 7 (5.47%) 47 (9.48%)
C cardiovascular system N (%) 703 (18.22%) 20 (14.29%) 464 (19.46%) 26 (20.31%) 126 (25.40%)
Conditions any time prior Diseases of the nervous system N (%) 810 (20.99%) 31 (22.14%) 615 (25.80%) 31 (24.22%) 157 (31.65%)
Certain conditions originating in the perinatal period N (%) 37 (0.96%) - 33 (1.38%) 33 (25.78%) 7 (1.41%)
Certain infectious and parasitic diseases N (%) 1,792 (46.44%) 69 (49.29%) 1,134 (47.57%) 72 (56.25%) 262 (52.82%)
Mental and behavioural disorders N (%) 290 (7.51%) 9 (6.43%) 214 (8.98%) 9 (7.03%) 63 (12.70%)
Pregnancy childbirth and the puerperium N (%) 641 (16.61%) 21 (15.00%) 387 (16.23%) 41 (32.03%) 70 (14.11%)
Endocrine nutritional and metabolic diseases N (%) 201 (5.21%) 6 (4.29%) 125 (5.24%) 54 (42.19%) 26 (5.24%)
Neoplasms N (%) 132 (3.42%) - 69 (2.89%) - 9 (1.81%)
Diseases of the digestive system N (%) 591 (15.31%) 22 (15.71%) 414 (17.37%) 23 (17.97%) 122 (24.60%)
Diseases of the circulatory system N (%) 1,017 (26.35%) 50 (35.71%) 682 (28.61%) 59 (46.09%) 168 (33.87%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 3,482 (90.23%) 131 (93.57%) 2,167 (90.90%) 126 (98.44%) 473 (95.36%)
Diseases of the skin and subcutaneous tissue N (%) 961 (24.90%) 40 (28.57%) 589 (24.71%) 35 (27.34%) 125 (25.20%)
Injury poisoning and certain other consequences of external causes N (%) 1,532 (39.70%) 60 (42.86%) 1,069 (44.84%) 58 (45.31%) 270 (54.44%)
Diseases of the ear and mastoid process N (%) 192 (4.98%) - 152 (6.38%) 10 (7.81%) 41 (8.27%)
Diseases of the genitourinary system N (%) 707 (18.32%) 36 (25.71%) 456 (19.13%) 38 (29.69%) 104 (20.97%)
Diseases of the respiratory system N (%) 613 (15.88%) 25 (17.86%) 489 (20.51%) 25 (19.53%) 112 (22.58%)
Congenital malformations deformations and chromosomal abnormalities N (%) 15 (0.39%) - 11 (0.46%) - -
Codes for special purposes N (%) 480 (12.44%) 17 (12.14%) 325 (13.63%) 14 (10.94%) 92 (18.55%)
Diseases of the musculoskeletal system and connective tissue N (%) 1,192 (30.89%) 52 (37.14%) 764 (32.05%) 44 (34.38%) 188 (37.90%)
Diseases of the eye and adnexa N (%) 245 (6.35%) 6 (4.29%) 139 (5.83%) 28 (21.88%) 33 (6.65%)
Factors influencing health status and contact with health services N (%) 3,456 (89.56%) 136 (97.14%) 2,186 (91.69%) 123 (96.09%) 480 (96.77%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 340 (8.81%) 12 (8.57%) 262 (10.99%) 9 (7.03%) 53 (10.69%)
External causes of morbidity and mortality N (%) 78 (2.02%) - 81 (3.40%) 0 (0.00%) 32 (6.45%)
Male Number records - N 2,056 85 1,429 52 281
Number subjects - N 1,615 79 1,143 42 251
Cohort start date - Median [Q25 - Q75] 2013-08-19 [2011-10-13 - 2016-03-06] 2013-10-04 [2012-01-12 - 2016-06-15] 2014-03-10 [2012-01-11 - 2016-11-01] 2014-05-18 [2012-08-15 - 2016-11-11] 2013-08-05 [2011-11-21 - 2015-10-20]
Range 2010-01-04 to 2019-12-31 2010-02-01 to 2019-11-29 2010-01-04 to 2019-12-30 2010-06-02 to 2019-05-07 2010-01-20 to 2019-12-05
Cohort end date - Median [Q25 - Q75] 2013-08-25 [2011-10-19 - 2016-03-11] 2013-10-04 [2012-01-14 - 2016-06-22] 2014-04-08 [2012-02-04 - 2016-11-28] 2015-07-14 [2013-01-06 - 2017-09-29] 2013-09-27 [2012-01-04 - 2016-01-27]
Range 2010-01-08 to 2020-01-06 2010-02-01 to 2019-11-29 2010-01-11 to 2022-08-28 2011-04-10 to 2024-06-09 2010-02-01 to 2023-09-13
Age - Median [Q25 - Q75] 31 [25 - 35] 25 [23 - 31] 31 [26 - 35] 34 [30 - 37] 31 [27 - 36]
Mean (SD) 30.25 (5.83) 26.85 (5.53) 30.35 (5.59) 33.06 (4.83) 30.76 (5.51)
Range 20 to 39 20 to 39 20 to 39 20 to 39 20 to 39
Age group 20 to 39 N (%) 2,056 (100.00%) 85 (100.00%) 1,429 (100.00%) 52 (100.00%) 281 (100.00%)
Sex Male N (%) 2,056 (100.00%) 85 (100.00%) 1,429 (100.00%) 52 (100.00%) 281 (100.00%)
Prior observation - Median [Q25 - Q75] 3,449 [1,751 - 5,053] 3,988 [3,221 - 5,265] 3,440 [1,547 - 5,072] 2,929 [966 - 4,604] 3,489 [1,476 - 4,875]
Mean (SD) 3,580.31 (2,151.12) 4,094.94 (1,725.37) 3,534.42 (2,209.48) 3,032.75 (2,040.53) 3,505.25 (2,253.71)
Range 368 to 10,751 411 to 8,203 370 to 10,620 397 to 8,072 375 to 9,871
Future observation - Median [Q25 - Q75] 1,923 [875 - 3,246] 2,096 [1,152 - 3,397] 2,022 [948 - 3,115] 1,843 [1,062 - 2,643] 1,915 [896 - 3,333]
Mean (SD) 2,131.17 (1,450.62) 2,283.32 (1,407.68) 2,143.85 (1,409.21) 1,901.63 (1,191.19) 2,113.03 (1,459.49)
Range 1 to 5,270 16 to 5,019 0 to 5,269 77 to 5,070 1 to 5,156
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 1 [1 - 6] 13 [8 - 28] 96 [41 - 304] 28 [20 - 55]
Mean (SD) 7.23 (3.93) 5.56 (21.01) 28.15 (118.82) 393.33 (722.18) 84.77 (218.05)
Range 2 to 62 1 to 193 1 to 2,745 28 to 3,118 2 to 2,199
Number of visits in the year prior - Median [Q25 - Q75] 5.00 [2.00 - 12.00] 5.00 [1.00 - 11.00] 6.00 [2.00 - 14.00] 16.00 [8.00 - 22.00] 11.00 [5.00 - 22.00]
Mean (SD) 9.27 (11.59) 8.02 (10.08) 10.22 (11.91) 20.21 (19.30) 15.21 (13.99)
Range 0.00 to 99.00 0.00 to 58.00 0.00 to 108.00 2.00 to 93.00 0.00 to 74.00
Medications in the year prior D dermatologicals N (%) 475 (23.10%) 22 (25.88%) 323 (22.60%) 14 (26.92%) 70 (24.91%)
N nervous system N (%) 631 (30.69%) 27 (31.76%) 493 (34.50%) 21 (40.38%) 182 (64.77%)
R respiratory system N (%) 541 (26.31%) 21 (24.71%) 366 (25.61%) 13 (25.00%) 101 (35.94%)
S sensory organs N (%) 126 (6.13%) - 85 (5.95%) - 20 (7.12%)
A alimentary tract and metabolism N (%) 470 (22.86%) 15 (17.65%) 339 (23.72%) 28 (53.85%) 108 (38.43%)
B blood and blood forming organs N (%) 116 (5.64%) - 116 (8.12%) - 33 (11.74%)
P antiparasitic products insecticides and repellents N (%) 40 (1.95%) - 22 (1.54%) 0 (0.00%) 5 (1.78%)
J antiinfectives for systemic use N (%) 463 (22.52%) 31 (36.47%) 477 (33.38%) 23 (44.23%) 110 (39.15%)
G genito urinary system and sex hormones N (%) 105 (5.11%) 8 (9.41%) 90 (6.30%) 7 (13.46%) 14 (4.98%)
M musculo skeletal system N (%) 355 (17.27%) 14 (16.47%) 345 (24.14%) 10 (19.23%) 119 (42.35%)
V various N (%) 24 (1.17%) - 18 (1.26%) - -
H systemic hormonal preparations excl sex hormones and insulins N (%) 76 (3.70%) 5 (5.88%) 59 (4.13%) - 18 (6.41%)
L antineoplastic and immunomodulating agents N (%) 27 (1.31%) 0 (0.00%) 21 (1.47%) 0 (0.00%) -
C cardiovascular system N (%) 268 (13.04%) - 191 (13.37%) 15 (28.85%) 43 (15.30%)
Conditions any time prior Diseases of the nervous system N (%) 290 (14.11%) 9 (10.59%) 243 (17.00%) 5 (9.62%) 57 (20.28%)
Certain conditions originating in the perinatal period N (%) 27 (1.31%) 0 (0.00%) 17 (1.19%) 23 (44.23%) -
Certain infectious and parasitic diseases N (%) 678 (32.98%) 21 (24.71%) 479 (33.52%) 28 (53.85%) 119 (42.35%)
Mental and behavioural disorders N (%) 119 (5.79%) 6 (7.06%) 112 (7.84%) 5 (9.62%) 22 (7.83%)
Pregnancy childbirth and the puerperium N (%) - 0 (0.00%) 0 (0.00%) 0 (0.00%) -
Endocrine nutritional and metabolic diseases N (%) 41 (1.99%) 0 (0.00%) 32 (2.24%) 27 (51.92%) 10 (3.56%)
Neoplasms N (%) 42 (2.04%) - 28 (1.96%) - 7 (2.49%)
Diseases of the digestive system N (%) 212 (10.31%) 5 (5.88%) 159 (11.13%) 9 (17.31%) 47 (16.73%)
Diseases of the circulatory system N (%) 341 (16.59%) 12 (14.12%) 237 (16.59%) 30 (57.69%) 60 (21.35%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 1,445 (70.28%) 54 (63.53%) 1,058 (74.04%) 51 (98.08%) 241 (85.77%)
Diseases of the skin and subcutaneous tissue N (%) 385 (18.73%) 12 (14.12%) 289 (20.22%) 12 (23.08%) 67 (23.84%)
Injury poisoning and certain other consequences of external causes N (%) 582 (28.31%) 21 (24.71%) 465 (32.54%) 22 (42.31%) 118 (41.99%)
Diseases of the ear and mastoid process N (%) 91 (4.43%) - 78 (5.46%) - 16 (5.69%)
Diseases of the genitourinary system N (%) 81 (3.94%) - 56 (3.92%) 8 (15.38%) 16 (5.69%)
Diseases of the respiratory system N (%) 219 (10.65%) 7 (8.24%) 172 (12.04%) 6 (11.54%) 57 (20.28%)
Congenital malformations deformations and chromosomal abnormalities N (%) 6 (0.29%) 0 (0.00%) 7 (0.49%) 0 (0.00%) 0 (0.00%)
Codes for special purposes N (%) 172 (8.37%) 9 (10.59%) 102 (7.14%) - 34 (12.10%)
Diseases of the musculoskeletal system and connective tissue N (%) 508 (24.71%) 13 (15.29%) 399 (27.92%) 13 (25.00%) 106 (37.72%)
Diseases of the eye and adnexa N (%) 90 (4.38%) 0 (0.00%) 51 (3.57%) 13 (25.00%) 10 (3.56%)
Factors influencing health status and contact with health services N (%) 1,444 (70.23%) 60 (70.59%) 1,085 (75.93%) 51 (98.08%) 254 (90.39%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 117 (5.69%) - 86 (6.02%) - 22 (7.83%)
External causes of morbidity and mortality N (%) 20 (0.97%) - 25 (1.75%) - 10 (3.56%)
40 to 59 Female Number records - N 4,514 49 3,171 204 880
Number subjects - N 2,940 47 2,292 195 728
Cohort start date - Median [Q25 - Q75] 2013-10-30 [2011-11-15 - 2016-02-26] 2013-07-29 [2012-01-23 - 2015-09-17] 2014-01-28 [2012-01-05 - 2016-07-13] 2014-03-29 [2012-06-25 - 2016-07-18] 2013-08-21 [2011-10-19 - 2015-10-29]
Range 2010-01-04 to 2019-12-31 2010-01-25 to 2019-09-18 2010-01-04 to 2019-12-27 2010-01-25 to 2019-12-20 2010-01-05 to 2019-12-30
Cohort end date - Median [Q25 - Q75] 2013-11-05 [2011-11-21 - 2016-03-05] 2013-09-19 [2012-06-27 - 2015-09-19] 2014-03-04 [2012-02-08 - 2016-08-22] 2015-06-08 [2013-04-04 - 2018-04-19] 2013-11-01 [2011-12-25 - 2016-02-23]
Range 2010-01-08 to 2020-01-08 2010-01-27 to 2020-08-18 2010-01-07 to 2024-02-27 2010-04-14 to 2024-06-09 2010-01-24 to 2024-06-09
Age - Median [Q25 - Q75] 50 [45 - 54] 50 [43 - 54] 50 [45 - 54] 51 [45 - 56] 50 [45 - 55]
Mean (SD) 49.52 (5.70) 49.18 (5.87) 49.57 (5.68) 50.27 (6.01) 49.75 (5.68)
Range 40 to 59 40 to 59 40 to 59 40 to 59 40 to 59
Age group 40 to 59 N (%) 4,514 (100.00%) 49 (100.00%) 3,171 (100.00%) 204 (100.00%) 880 (100.00%)
Sex Female N (%) 4,514 (100.00%) 49 (100.00%) 3,171 (100.00%) 204 (100.00%) 880 (100.00%)
Prior observation - Median [Q25 - Q75] 3,870 [2,518 - 5,191] 3,554 [2,465 - 4,566] 3,848 [2,414 - 5,230] 3,518 [1,442 - 5,193] 3,714 [2,381 - 4,933]
Mean (SD) 3,915.81 (2,002.17) 3,625.24 (1,630.22) 3,881.32 (2,051.85) 3,541.75 (2,210.77) 3,713.22 (1,919.92)
Range 365 to 10,833 380 to 7,318 365 to 10,805 369 to 9,708 369 to 10,114
Future observation - Median [Q25 - Q75] 2,090 [1,032 - 3,426] 1,924 [1,143 - 3,616] 2,246 [1,131 - 3,494] 1,747 [768 - 2,871] 2,322 [1,079 - 3,591]
Mean (SD) 2,272.06 (1,447.41) 2,261.88 (1,498.87) 2,363.47 (1,443.23) 1,961.45 (1,385.47) 2,374.68 (1,473.57)
Range 6 to 5,269 200 to 5,218 5 to 5,270 11 to 5,170 3 to 5,257
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 3 [1 - 8] 13 [8 - 28] 163 [56 - 666] 28 [20 - 46]
Mean (SD) 7.62 (5.38) 47.67 (144.84) 36.57 (152.07) 563.53 (838.98) 112.54 (379.00)
Range 1 to 102 1 to 694 1 to 4,527 12 to 4,661 1 to 4,168
Number of visits in the year prior - Median [Q25 - Q75] 15.00 [8.00 - 26.00] 22.00 [13.00 - 36.00] 16.00 [9.00 - 26.00] 26.50 [14.75 - 37.00] 24.00 [14.00 - 36.00]
Mean (SD) 19.16 (16.73) 25.73 (17.28) 19.80 (16.36) 29.37 (20.70) 27.59 (18.94)
Range 0.00 to 207.00 0.00 to 75.00 0.00 to 156.00 1.00 to 166.00 0.00 to 161.00
Medications in the year prior D dermatologicals N (%) 1,377 (30.51%) 19 (38.78%) 1,013 (31.95%) 88 (43.14%) 337 (38.30%)
N nervous system N (%) 2,568 (56.89%) 35 (71.43%) 1,796 (56.64%) 140 (68.63%) 734 (83.41%)
R respiratory system N (%) 1,770 (39.21%) 30 (61.22%) 1,253 (39.51%) 96 (47.06%) 471 (53.52%)
S sensory organs N (%) 464 (10.28%) 5 (10.20%) 329 (10.38%) 24 (11.76%) 112 (12.73%)
A alimentary tract and metabolism N (%) 1,951 (43.22%) 28 (57.14%) 1,465 (46.20%) 121 (59.31%) 568 (64.55%)
B blood and blood forming organs N (%) 811 (17.97%) 13 (26.53%) 600 (18.92%) 49 (24.02%) 247 (28.07%)
P antiparasitic products insecticides and repellents N (%) 239 (5.29%) - 173 (5.46%) 14 (6.86%) 76 (8.64%)
J antiinfectives for systemic use N (%) 1,695 (37.55%) 37 (75.51%) 1,598 (50.39%) 118 (57.84%) 490 (55.68%)
G genito urinary system and sex hormones N (%) 1,373 (30.42%) 15 (30.61%) 998 (31.47%) 67 (32.84%) 293 (33.30%)
M musculo skeletal system N (%) 1,374 (30.44%) 16 (32.65%) 1,095 (34.53%) 76 (37.25%) 512 (58.18%)
V various N (%) 270 (5.98%) 5 (10.20%) 177 (5.58%) 13 (6.37%) 80 (9.09%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 718 (15.91%) 21 (42.86%) 555 (17.50%) 49 (24.02%) 231 (26.25%)
L antineoplastic and immunomodulating agents N (%) 226 (5.01%) - 141 (4.45%) 7 (3.43%) 72 (8.18%)
C cardiovascular system N (%) 1,549 (34.32%) 25 (51.02%) 1,118 (35.26%) 109 (53.43%) 399 (45.34%)
Conditions any time prior Diseases of the nervous system N (%) 925 (20.49%) 9 (18.37%) 730 (23.02%) 52 (25.49%) 280 (31.82%)
Certain conditions originating in the perinatal period N (%) 117 (2.59%) - 93 (2.93%) 65 (31.86%) 23 (2.61%)
Certain infectious and parasitic diseases N (%) 1,836 (40.67%) 20 (40.82%) 1,308 (41.25%) 112 (54.90%) 398 (45.23%)
Mental and behavioural disorders N (%) 289 (6.40%) - 219 (6.91%) 18 (8.82%) 81 (9.20%)
Pregnancy childbirth and the puerperium N (%) 167 (3.70%) - 99 (3.12%) 13 (6.37%) 28 (3.18%)
Endocrine nutritional and metabolic diseases N (%) 243 (5.38%) - 188 (5.93%) 79 (38.73%) 65 (7.39%)
Neoplasms N (%) 217 (4.81%) - 141 (4.45%) 10 (4.90%) 44 (5.00%)
Diseases of the digestive system N (%) 543 (12.03%) 8 (16.33%) 424 (13.37%) 24 (11.76%) 171 (19.43%)
Diseases of the circulatory system N (%) 1,055 (23.37%) 22 (44.90%) 872 (27.50%) 110 (53.92%) 277 (31.48%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 4,020 (89.06%) 46 (93.88%) 2,873 (90.60%) 200 (98.04%) 843 (95.80%)
Diseases of the skin and subcutaneous tissue N (%) 1,023 (22.66%) 11 (22.45%) 736 (23.21%) 59 (28.92%) 249 (28.30%)
Injury poisoning and certain other consequences of external causes N (%) 1,636 (36.24%) 24 (48.98%) 1,249 (39.39%) 87 (42.65%) 412 (46.82%)
Diseases of the ear and mastoid process N (%) 269 (5.96%) - 198 (6.24%) 14 (6.86%) 59 (6.70%)
Diseases of the genitourinary system N (%) 696 (15.42%) 10 (20.41%) 484 (15.26%) 39 (19.12%) 152 (17.27%)
Diseases of the respiratory system N (%) 584 (12.94%) 21 (42.86%) 611 (19.27%) 55 (26.96%) 212 (24.09%)
Congenital malformations deformations and chromosomal abnormalities N (%) 14 (0.31%) 0 (0.00%) 9 (0.28%) 0 (0.00%) -
Codes for special purposes N (%) 658 (14.58%) 9 (18.37%) 520 (16.40%) 44 (21.57%) 170 (19.32%)
Diseases of the musculoskeletal system and connective tissue N (%) 1,437 (31.83%) 22 (44.90%) 1,047 (33.02%) 76 (37.25%) 381 (43.30%)
Diseases of the eye and adnexa N (%) 318 (7.04%) - 214 (6.75%) 40 (19.61%) 67 (7.61%)
Factors influencing health status and contact with health services N (%) 4,015 (88.95%) 45 (91.84%) 2,913 (91.86%) 202 (99.02%) 848 (96.36%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 273 (6.05%) 5 (10.20%) 234 (7.38%) 16 (7.84%) 91 (10.34%)
External causes of morbidity and mortality N (%) 116 (2.57%) - 113 (3.56%) 9 (4.41%) 46 (5.23%)
Male Number records - N 3,110 29 2,369 306 620
Number subjects - N 2,195 29 1,792 292 532
Cohort start date - Median [Q25 - Q75] 2013-07-24 [2011-10-19 - 2015-12-30] 2015-11-21 [2013-02-12 - 2018-01-05] 2014-01-17 [2011-12-08 - 2016-07-07] 2013-11-25 [2012-01-13 - 2016-07-23] 2013-07-03 [2011-10-26 - 2015-07-01]
Range 2010-01-04 to 2019-12-31 2010-12-17 to 2019-07-29 2010-01-11 to 2019-12-30 2010-01-15 to 2019-12-12 2010-01-07 to 2019-12-06
Cohort end date - Median [Q25 - Q75] 2013-07-30 [2011-10-31 - 2016-01-06] 2015-11-23 [2013-02-12 - 2018-10-04] 2014-02-17 [2012-01-19 - 2016-08-05] 2015-08-07 [2013-06-16 - 2018-06-18] 2013-09-26 [2012-01-12 - 2015-10-29]
Range 2010-01-09 to 2020-01-05 2010-12-19 to 2024-03-03 2010-01-14 to 2024-06-09 2010-02-26 to 2024-06-09 2010-02-03 to 2023-09-18
Age - Median [Q25 - Q75] 50 [45 - 55] 50 [45 - 54] 50 [45 - 55] 52 [46 - 56] 50 [46 - 55]
Mean (SD) 50.04 (5.68) 49.55 (5.44) 49.91 (5.67) 51.20 (5.63) 50.02 (5.62)
Range 40 to 59 41 to 59 40 to 59 40 to 59 40 to 59
Age group 40 to 59 N (%) 3,110 (100.00%) 29 (100.00%) 2,369 (100.00%) 306 (100.00%) 620 (100.00%)
Sex Male N (%) 3,110 (100.00%) 29 (100.00%) 2,369 (100.00%) 306 (100.00%) 620 (100.00%)
Prior observation - Median [Q25 - Q75] 3,794 [2,389 - 5,100] 3,360 [2,259 - 5,629] 3,770 [2,185 - 5,151] 3,350 [1,574 - 4,803] 3,515 [2,068 - 4,864]
Mean (SD) 3,828.42 (1,972.04) 3,701.28 (2,151.24) 3,770.53 (2,080.07) 3,456.58 (2,244.90) 3,581.67 (1,995.97)
Range 367 to 10,601 553 to 7,645 365 to 11,385 371 to 10,781 367 to 9,436
Future observation - Median [Q25 - Q75] 2,082 [960 - 3,423] 2,148 [834 - 2,634] 2,167 [1,032 - 3,429] 1,943 [962 - 3,181] 2,046 [966 - 3,376]
Mean (SD) 2,259.01 (1,465.06) 2,082.03 (1,257.13) 2,303.08 (1,453.95) 2,109.92 (1,380.28) 2,225.51 (1,461.82)
Range 0 to 5,269 69 to 4,585 4 to 5,263 7 to 5,241 13 to 5,267
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 3 [1 - 8] 13 [8 - 28] 273 [75 - 850] 28 [28 - 48]
Mean (SD) 7.48 (4.96) 165.97 (515.51) 34.91 (157.41) 668.68 (932.37) 91.86 (299.60)
Range 1 to 86 1 to 2,149 2 to 3,056 8 to 4,855 2 to 4,386
Number of visits in the year prior - Median [Q25 - Q75] 11.00 [4.00 - 22.00] 14.00 [8.00 - 38.00] 12.00 [5.00 - 22.00] 20.00 [12.00 - 30.75] 18.00 [8.00 - 30.00]
Mean (SD) 15.09 (15.95) 24.97 (33.92) 15.91 (15.80) 22.79 (14.90) 22.83 (22.48)
Range 0.00 to 310.00 0.00 to 171.00 0.00 to 144.00 0.00 to 107.00 0.00 to 312.00
Medications in the year prior D dermatologicals N (%) 735 (23.63%) 8 (27.59%) 527 (22.25%) 88 (28.76%) 168 (27.10%)
N nervous system N (%) 1,283 (41.25%) 12 (41.38%) 979 (41.33%) 157 (51.31%) 448 (72.26%)
R respiratory system N (%) 953 (30.64%) 11 (37.93%) 697 (29.42%) 90 (29.41%) 248 (40.00%)
S sensory organs N (%) 238 (7.65%) - 156 (6.59%) 29 (9.48%) 56 (9.03%)
A alimentary tract and metabolism N (%) 1,205 (38.75%) 15 (51.72%) 934 (39.43%) 163 (53.27%) 350 (56.45%)
B blood and blood forming organs N (%) 355 (11.41%) - 271 (11.44%) 55 (17.97%) 109 (17.58%)
P antiparasitic products insecticides and repellents N (%) 86 (2.77%) - 70 (2.95%) 9 (2.94%) 22 (3.55%)
J antiinfectives for systemic use N (%) 703 (22.60%) 20 (68.97%) 783 (33.05%) 101 (33.01%) 247 (39.84%)
G genito urinary system and sex hormones N (%) 387 (12.44%) 6 (20.69%) 302 (12.75%) 54 (17.65%) 112 (18.06%)
M musculo skeletal system N (%) 778 (25.02%) 5 (17.24%) 740 (31.24%) 85 (27.78%) 314 (50.65%)
V various N (%) 90 (2.89%) - 63 (2.66%) 8 (2.61%) 30 (4.84%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 222 (7.14%) 7 (24.14%) 196 (8.27%) 32 (10.46%) 62 (10.00%)
L antineoplastic and immunomodulating agents N (%) 66 (2.12%) 0 (0.00%) 38 (1.60%) 7 (2.29%) 25 (4.03%)
C cardiovascular system N (%) 1,120 (36.01%) 6 (20.69%) 871 (36.77%) 193 (63.07%) 266 (42.90%)
Conditions any time prior Diseases of the nervous system N (%) 443 (14.24%) - 388 (16.38%) 49 (16.01%) 156 (25.16%)
Certain conditions originating in the perinatal period N (%) 137 (4.41%) - 90 (3.80%) 96 (31.37%) 34 (5.48%)
Certain infectious and parasitic diseases N (%) 1,010 (32.48%) 14 (48.28%) 776 (32.76%) 147 (48.04%) 249 (40.16%)
Mental and behavioural disorders N (%) 125 (4.02%) - 100 (4.22%) 13 (4.25%) 42 (6.77%)
Pregnancy childbirth and the puerperium N (%) 11 (0.35%) 0 (0.00%) 6 (0.25%) - -
Endocrine nutritional and metabolic diseases N (%) 182 (5.85%) - 145 (6.12%) 110 (35.95%) 57 (9.19%)
Neoplasms N (%) 109 (3.50%) 0 (0.00%) 91 (3.84%) 11 (3.59%) 37 (5.97%)
Diseases of the digestive system N (%) 278 (8.94%) 8 (27.59%) 237 (10.00%) 33 (10.78%) 83 (13.39%)
Diseases of the circulatory system N (%) 641 (20.61%) 8 (27.59%) 517 (21.82%) 152 (49.67%) 179 (28.87%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 2,489 (80.03%) 26 (89.66%) 1,965 (82.95%) 299 (97.71%) 558 (90.00%)
Diseases of the skin and subcutaneous tissue N (%) 625 (20.10%) 8 (27.59%) 499 (21.06%) 69 (22.55%) 165 (26.61%)
Injury poisoning and certain other consequences of external causes N (%) 833 (26.78%) 12 (41.38%) 712 (30.05%) 100 (32.68%) 236 (38.06%)
Diseases of the ear and mastoid process N (%) 134 (4.31%) - 89 (3.76%) 15 (4.90%) 31 (5.00%)
Diseases of the genitourinary system N (%) 148 (4.76%) - 120 (5.07%) 25 (8.17%) 48 (7.74%)
Diseases of the respiratory system N (%) 344 (11.06%) 9 (31.03%) 321 (13.55%) 48 (15.69%) 112 (18.06%)
Congenital malformations deformations and chromosomal abnormalities N (%) 16 (0.51%) 0 (0.00%) 12 (0.51%) - 9 (1.45%)
Codes for special purposes N (%) 488 (15.69%) 7 (24.14%) 395 (16.67%) 79 (25.82%) 113 (18.23%)
Diseases of the musculoskeletal system and connective tissue N (%) 822 (26.43%) 10 (34.48%) 735 (31.03%) 94 (30.72%) 241 (38.87%)
Diseases of the eye and adnexa N (%) 195 (6.27%) - 151 (6.37%) 57 (18.63%) 59 (9.52%)
Factors influencing health status and contact with health services N (%) 2,486 (79.94%) 26 (89.66%) 1,979 (83.54%) 300 (98.04%) 570 (91.94%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 159 (5.11%) - 125 (5.28%) 16 (5.23%) 41 (6.61%)
External causes of morbidity and mortality N (%) 60 (1.93%) - 63 (2.66%) 10 (3.27%) 25 (4.03%)
60 to 79 Female Number records - N 3,883 68 2,604 268 758
Number subjects - N 2,421 62 1,927 254 647
Cohort start date - Median [Q25 - Q75] 2013-12-23 [2011-12-09 - 2016-06-14] 2015-03-15 [2012-12-08 - 2017-02-05] 2014-01-31 [2012-01-17 - 2016-06-10] 2013-09-30 [2011-11-26 - 2016-10-20] 2013-05-31 [2011-09-21 - 2015-11-10]
Range 2010-01-04 to 2019-12-31 2010-03-16 to 2019-11-13 2010-01-05 to 2019-12-31 2010-01-06 to 2019-12-05 2010-01-05 to 2019-11-18
Cohort end date - Median [Q25 - Q75] 2013-12-30 [2011-12-18 - 2016-06-24] 2015-04-05 [2013-03-28 - 2018-02-09] 2014-03-17 [2012-02-10 - 2016-07-25] 2015-06-20 [2013-01-09 - 2018-05-05] 2013-08-09 [2011-11-30 - 2016-02-07]
Range 2010-01-08 to 2020-01-23 2010-03-18 to 2024-06-09 2010-01-14 to 2024-06-09 2010-05-16 to 2024-06-10 2010-01-17 to 2024-06-09
Age - Median [Q25 - Q75] 68 [64 - 74] 69 [65 - 73] 69 [64 - 74] 68 [64 - 74] 69 [64 - 74]
Mean (SD) 68.77 (5.64) 69.01 (5.66) 68.86 (5.62) 68.91 (5.72) 68.82 (5.65)
Range 60 to 79 60 to 79 60 to 79 60 to 79 60 to 79
Age group 60 to 79 N (%) 3,883 (100.00%) 68 (100.00%) 2,604 (100.00%) 268 (100.00%) 758 (100.00%)
Sex Female N (%) 3,883 (100.00%) 68 (100.00%) 2,604 (100.00%) 268 (100.00%) 758 (100.00%)
Prior observation - Median [Q25 - Q75] 4,387 [3,070 - 5,636] 4,728 [3,300 - 5,560] 4,226 [2,944 - 5,569] 3,868 [2,230 - 5,304] 4,075 [2,846 - 5,384]
Mean (SD) 4,405.89 (2,046.92) 4,334.94 (1,757.47) 4,281.13 (2,064.11) 3,830.25 (2,181.89) 4,143.81 (2,004.77)
Range 365 to 10,883 450 to 7,374 365 to 10,657 365 to 10,105 365 to 10,644
Future observation - Median [Q25 - Q75] 1,971 [977 - 3,156] 1,795 [670 - 2,650] 1,894 [860 - 3,049] 1,652 [743 - 2,800] 1,848 [890 - 2,956]
Mean (SD) 2,142.64 (1,386.26) 1,822.38 (1,270.03) 2,048.40 (1,391.43) 1,931.94 (1,395.37) 2,027.73 (1,385.53)
Range 1 to 5,269 21 to 4,429 2 to 5,268 34 to 5,263 3 to 5,267
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 5 [3 - 100] 14 [9 - 28] 304 [84 - 807] 28 [28 - 49]
Mean (SD) 8.13 (13.05) 177.31 (428.08) 46.70 (179.85) 580.41 (707.28) 85.91 (259.96)
Range 1 to 620 1 to 1,819 1 to 5,099 14 to 4,747 1 to 3,106
Number of visits in the year prior - Median [Q25 - Q75] 24.00 [15.00 - 36.00] 40.00 [28.75 - 53.75] 25.00 [16.00 - 37.00] 31.00 [21.00 - 43.00] 31.00 [21.00 - 43.00]
Mean (SD) 27.40 (18.19) 45.62 (25.74) 28.66 (18.42) 34.01 (18.39) 34.84 (20.37)
Range 0.00 to 156.00 3.00 to 137.00 0.00 to 151.00 3.00 to 142.00 2.00 to 153.00
Medications in the year prior D dermatologicals N (%) 1,371 (35.31%) 31 (45.59%) 919 (35.29%) 114 (42.54%) 331 (43.67%)
N nervous system N (%) 2,647 (68.17%) 54 (79.41%) 1,732 (66.51%) 194 (72.39%) 667 (87.99%)
R respiratory system N (%) 1,770 (45.58%) 59 (86.76%) 1,131 (43.43%) 119 (44.40%) 427 (56.33%)
S sensory organs N (%) 650 (16.74%) 23 (33.82%) 437 (16.78%) 46 (17.16%) 140 (18.47%)
A alimentary tract and metabolism N (%) 2,535 (65.28%) 59 (86.76%) 1,802 (69.20%) 188 (70.15%) 606 (79.95%)
B blood and blood forming organs N (%) 944 (24.31%) 29 (42.65%) 642 (24.65%) 83 (30.97%) 233 (30.74%)
P antiparasitic products insecticides and repellents N (%) 299 (7.70%) 5 (7.35%) 190 (7.30%) 18 (6.72%) 87 (11.48%)
J antiinfectives for systemic use N (%) 1,594 (41.05%) 62 (91.18%) 1,404 (53.92%) 152 (56.72%) 447 (58.97%)
G genito urinary system and sex hormones N (%) 758 (19.52%) 20 (29.41%) 496 (19.05%) 60 (22.39%) 165 (21.77%)
M musculo skeletal system N (%) 1,439 (37.06%) 32 (47.06%) 1,065 (40.90%) 99 (36.94%) 425 (56.07%)
V various N (%) 320 (8.24%) 11 (16.18%) 187 (7.18%) 27 (10.07%) 68 (8.97%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 969 (24.95%) 43 (63.24%) 764 (29.34%) 78 (29.10%) 280 (36.94%)
L antineoplastic and immunomodulating agents N (%) 194 (5.00%) - 112 (4.30%) 18 (6.72%) 48 (6.33%)
C cardiovascular system N (%) 2,557 (65.85%) 48 (70.59%) 1,784 (68.51%) 234 (87.31%) 571 (75.33%)
Conditions any time prior Diseases of the nervous system N (%) 896 (23.07%) 19 (27.94%) 643 (24.69%) 66 (24.63%) 246 (32.45%)
Certain conditions originating in the perinatal period N (%) 179 (4.61%) - 141 (5.41%) 87 (32.46%) 51 (6.73%)
Certain infectious and parasitic diseases N (%) 1,845 (47.51%) 41 (60.29%) 1,246 (47.85%) 164 (61.19%) 387 (51.06%)
Mental and behavioural disorders N (%) 106 (2.73%) - 97 (3.73%) 7 (2.61%) 27 (3.56%)
Pregnancy childbirth and the puerperium N (%) 104 (2.68%) - 68 (2.61%) 10 (3.73%) 21 (2.77%)
Endocrine nutritional and metabolic diseases N (%) 325 (8.37%) 5 (7.35%) 249 (9.56%) 98 (36.57%) 86 (11.35%)
Neoplasms N (%) 278 (7.16%) 6 (8.82%) 194 (7.45%) 17 (6.34%) 60 (7.92%)
Diseases of the digestive system N (%) 525 (13.52%) 17 (25.00%) 379 (14.55%) 34 (12.69%) 127 (16.75%)
Diseases of the circulatory system N (%) 1,048 (26.99%) 42 (61.76%) 865 (33.22%) 143 (53.36%) 291 (38.39%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 3,608 (92.92%) 66 (97.06%) 2,490 (95.62%) 267 (99.63%) 738 (97.36%)
Diseases of the skin and subcutaneous tissue N (%) 990 (25.50%) 22 (32.35%) 710 (27.27%) 68 (25.37%) 242 (31.93%)
Injury poisoning and certain other consequences of external causes N (%) 1,659 (42.72%) 50 (73.53%) 1,158 (44.47%) 118 (44.03%) 373 (49.21%)
Diseases of the ear and mastoid process N (%) 228 (5.87%) 5 (7.35%) 153 (5.88%) 22 (8.21%) 41 (5.41%)
Diseases of the genitourinary system N (%) 563 (14.50%) 8 (11.76%) 379 (14.55%) 53 (19.78%) 127 (16.75%)
Diseases of the respiratory system N (%) 609 (15.68%) 41 (60.29%) 578 (22.20%) 65 (24.25%) 201 (26.52%)
Congenital malformations deformations and chromosomal abnormalities N (%) 20 (0.52%) - 13 (0.50%) - -
Codes for special purposes N (%) 857 (22.07%) 21 (30.88%) 625 (24.00%) 77 (28.73%) 224 (29.55%)
Diseases of the musculoskeletal system and connective tissue N (%) 1,461 (37.63%) 33 (48.53%) 1,053 (40.44%) 97 (36.19%) 365 (48.15%)
Diseases of the eye and adnexa N (%) 469 (12.08%) 12 (17.65%) 293 (11.25%) 58 (21.64%) 79 (10.42%)
Factors influencing health status and contact with health services N (%) 3,658 (94.21%) 68 (100.00%) 2,484 (95.39%) 265 (98.88%) 744 (98.15%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 352 (9.07%) 12 (17.65%) 262 (10.06%) 25 (9.33%) 87 (11.48%)
External causes of morbidity and mortality N (%) 210 (5.41%) 8 (11.76%) 176 (6.76%) 17 (6.34%) 59 (7.78%)
Male Number records - N 3,114 48 2,077 323 562
Number subjects - N 2,013 43 1,535 304 473
Cohort start date - Median [Q25 - Q75] 2013-12-12 [2011-12-12 - 2016-05-12] 2014-03-07 [2012-01-18 - 2016-06-28] 2014-03-24 [2012-01-18 - 2016-08-05] 2013-09-12 [2011-11-02 - 2016-08-03] 2013-05-25 [2011-08-01 - 2015-09-11]
Range 2010-01-04 to 2019-12-31 2010-03-10 to 2019-11-22 2010-01-04 to 2019-12-23 2010-01-13 to 2019-12-17 2010-01-04 to 2019-12-13
Cohort end date - Median [Q25 - Q75] 2013-12-18 [2011-12-18 - 2016-05-18] 2014-12-13 [2012-06-04 - 2017-05-10] 2014-04-28 [2012-02-28 - 2016-10-08] 2015-08-08 [2013-06-02 - 2018-11-19] 2013-08-27 [2011-10-17 - 2016-01-24]
Range 2010-01-09 to 2020-01-22 2010-03-10 to 2023-08-27 2010-01-09 to 2024-06-09 2010-03-21 to 2024-06-09 2010-01-17 to 2024-06-06
Age - Median [Q25 - Q75] 68 [64 - 73] 68 [64 - 72] 68 [64 - 73] 68 [64 - 72] 69 [64 - 73]
Mean (SD) 68.81 (5.49) 67.77 (5.04) 68.81 (5.60) 68.25 (5.38) 68.81 (5.56)
Range 60 to 79 60 to 79 60 to 79 60 to 79 60 to 79
Age group 60 to 79 N (%) 3,114 (100.00%) 48 (100.00%) 2,077 (100.00%) 323 (100.00%) 562 (100.00%)
Sex Male N (%) 3,114 (100.00%) 48 (100.00%) 2,077 (100.00%) 323 (100.00%) 562 (100.00%)
Prior observation - Median [Q25 - Q75] 4,268 [2,892 - 5,536] 4,653 [3,119 - 5,523] 4,257 [2,891 - 5,562] 3,700 [1,690 - 5,314] 3,818 [2,577 - 5,252]
Mean (SD) 4,285.07 (2,067.60) 4,346.81 (1,823.60) 4,299.25 (2,085.62) 3,822.35 (2,381.52) 4,006.16 (2,062.69)
Range 368 to 11,197 434 to 7,695 366 to 10,691 370 to 10,441 383 to 10,576
Future observation - Median [Q25 - Q75] 1,857 [838 - 3,016] 1,464 [760 - 2,230] 1,866 [772 - 3,009] 1,714 [754 - 2,883] 1,900 [743 - 3,149]
Mean (SD) 2,018.26 (1,372.87) 1,691.60 (1,263.94) 1,990.14 (1,385.73) 1,899.54 (1,333.91) 2,046.71 (1,453.28)
Range 1 to 5,268 61 to 4,723 0 to 5,270 13 to 5,192 8 to 5,242
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 9 [3 - 119] 14 [9 - 28] 268 [80 - 892] 28 [28 - 57]
Mean (SD) 7.96 (5.78) 250.35 (496.11) 45.82 (177.60) 705.10 (949.51) 99.27 (322.02)
Range 1 to 84 1 to 1,690 1 to 3,562 14 to 5,001 3 to 4,700
Number of visits in the year prior - Median [Q25 - Q75] 24.00 [15.00 - 36.00] 38.50 [26.00 - 64.00] 25.00 [16.00 - 37.00] 27.00 [19.00 - 37.00] 31.50 [20.00 - 44.00]
Mean (SD) 27.48 (18.48) 46.48 (27.76) 28.12 (18.35) 30.01 (17.12) 34.51 (19.93)
Range 0.00 to 136.00 1.00 to 142.00 0.00 to 137.00 0.00 to 129.00 0.00 to 124.00
Medications in the year prior D dermatologicals N (%) 1,204 (38.66%) 24 (50.00%) 802 (38.61%) 125 (38.70%) 269 (47.86%)
N nervous system N (%) 1,977 (63.49%) 36 (75.00%) 1,244 (59.89%) 226 (69.97%) 480 (85.41%)
R respiratory system N (%) 1,298 (41.68%) 37 (77.08%) 813 (39.14%) 115 (35.60%) 257 (45.73%)
S sensory organs N (%) 474 (15.22%) 7 (14.58%) 296 (14.25%) 44 (13.62%) 98 (17.44%)
A alimentary tract and metabolism N (%) 1,869 (60.02%) 36 (75.00%) 1,281 (61.68%) 210 (65.02%) 416 (74.02%)
B blood and blood forming organs N (%) 859 (27.59%) 22 (45.83%) 634 (30.52%) 78 (24.15%) 212 (37.72%)
P antiparasitic products insecticides and repellents N (%) 155 (4.98%) - 102 (4.91%) 19 (5.88%) 55 (9.79%)
J antiinfectives for systemic use N (%) 946 (30.38%) 37 (77.08%) 910 (43.81%) 127 (39.32%) 285 (50.71%)
G genito urinary system and sex hormones N (%) 904 (29.03%) 18 (37.50%) 619 (29.80%) 110 (34.06%) 194 (34.52%)
M musculo skeletal system N (%) 1,032 (33.14%) 18 (37.50%) 791 (38.08%) 99 (30.65%) 286 (50.89%)
V various N (%) 220 (7.06%) - 143 (6.88%) 19 (5.88%) 56 (9.96%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 427 (13.71%) 31 (64.58%) 308 (14.83%) 46 (14.24%) 114 (20.28%)
L antineoplastic and immunomodulating agents N (%) 125 (4.01%) - 92 (4.43%) 10 (3.10%) 37 (6.58%)
C cardiovascular system N (%) 2,276 (73.09%) 36 (75.00%) 1,547 (74.48%) 273 (84.52%) 434 (77.22%)
Conditions any time prior Diseases of the nervous system N (%) 564 (18.11%) 10 (20.83%) 460 (22.15%) 58 (17.96%) 183 (32.56%)
Certain conditions originating in the perinatal period N (%) 196 (6.29%) 7 (14.58%) 167 (8.04%) 97 (30.03%) 44 (7.83%)
Certain infectious and parasitic diseases N (%) 1,422 (45.66%) 25 (52.08%) 1,020 (49.11%) 187 (57.89%) 303 (53.91%)
Mental and behavioural disorders N (%) 62 (1.99%) - 44 (2.12%) 5 (1.55%) 20 (3.56%)
Pregnancy childbirth and the puerperium N (%) 11 (0.35%) 0 (0.00%) 13 (0.63%) - -
Endocrine nutritional and metabolic diseases N (%) 301 (9.67%) 7 (14.58%) 248 (11.94%) 123 (38.08%) 69 (12.28%)
Neoplasms N (%) 243 (7.80%) - 195 (9.39%) 32 (9.91%) 65 (11.57%)
Diseases of the digestive system N (%) 377 (12.11%) 10 (20.83%) 301 (14.49%) 41 (12.69%) 97 (17.26%)
Diseases of the circulatory system N (%) 864 (27.75%) 26 (54.17%) 694 (33.41%) 161 (49.85%) 194 (34.52%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 2,891 (92.84%) 46 (95.83%) 1,964 (94.56%) 318 (98.45%) 548 (97.51%)
Diseases of the skin and subcutaneous tissue N (%) 816 (26.20%) 12 (25.00%) 552 (26.58%) 71 (21.98%) 175 (31.14%)
Injury poisoning and certain other consequences of external causes N (%) 1,262 (40.53%) 27 (56.25%) 914 (44.01%) 144 (44.58%) 288 (51.25%)
Diseases of the ear and mastoid process N (%) 173 (5.56%) - 152 (7.32%) 20 (6.19%) 42 (7.47%)
Diseases of the genitourinary system N (%) 346 (11.11%) 10 (20.83%) 217 (10.45%) 35 (10.84%) 75 (13.35%)
Diseases of the respiratory system N (%) 534 (17.15%) 27 (56.25%) 457 (22.00%) 71 (21.98%) 130 (23.13%)
Congenital malformations deformations and chromosomal abnormalities N (%) 29 (0.93%) 0 (0.00%) 26 (1.25%) 0 (0.00%) 6 (1.07%)
Codes for special purposes N (%) 1,038 (33.33%) 23 (47.92%) 702 (33.80%) 131 (40.56%) 205 (36.48%)
Diseases of the musculoskeletal system and connective tissue N (%) 1,122 (36.03%) 13 (27.08%) 798 (38.42%) 104 (32.20%) 279 (49.64%)
Diseases of the eye and adnexa N (%) 408 (13.10%) 6 (12.50%) 288 (13.87%) 73 (22.60%) 90 (16.01%)
Factors influencing health status and contact with health services N (%) 2,906 (93.32%) 47 (97.92%) 1,964 (94.56%) 319 (98.76%) 551 (98.04%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 212 (6.81%) 8 (16.67%) 169 (8.14%) 32 (9.91%) 57 (10.14%)
External causes of morbidity and mortality N (%) 115 (3.69%) - 92 (4.43%) 19 (5.88%) 33 (5.87%)
80 to 150 Female Number records - N 1,546 15 992 54 226
Number subjects - N 1,083 14 776 54 205
Cohort start date - Median [Q25 - Q75] 2013-12-04 [2011-12-28 - 2016-07-19] 2015-05-06 [2013-04-16 - 2017-08-26] 2014-01-10 [2012-01-27 - 2016-05-23] 2012-08-12 [2011-05-20 - 2016-05-21] 2013-07-31 [2011-11-29 - 2015-07-21]
Range 2010-01-04 to 2019-12-23 2010-02-03 to 2019-10-01 2010-01-04 to 2019-12-31 2010-01-19 to 2019-10-30 2010-01-05 to 2019-12-13
Cohort end date - Median [Q25 - Q75] 2013-12-11 [2012-01-05 - 2016-07-28] 2015-05-28 [2013-04-19 - 2017-08-28] 2014-03-20 [2012-03-13 - 2016-08-30] 2014-07-13 [2012-02-11 - 2017-06-06] 2013-09-18 [2012-02-16 - 2015-08-27]
Range 2010-01-08 to 2019-12-29 2010-03-30 to 2019-10-03 2010-01-12 to 2023-04-18 2010-06-16 to 2024-06-09 2010-01-18 to 2021-09-26
Age - Median [Q25 - Q75] 85 [82 - 90] 86 [81 - 89] 85 [82 - 89] 84 [82 - 87] 84 [82 - 88]
Mean (SD) 86.39 (5.19) 85.40 (4.82) 85.67 (4.64) 84.85 (3.92) 85.02 (4.12)
Range 80 to 112 80 to 96 80 to 106 80 to 98 80 to 102
Age group 80 to 150 N (%) 1,546 (100.00%) 15 (100.00%) 992 (100.00%) 54 (100.00%) 226 (100.00%)
Sex Female N (%) 1,546 (100.00%) 15 (100.00%) 992 (100.00%) 54 (100.00%) 226 (100.00%)
Prior observation - Median [Q25 - Q75] 4,239 [2,614 - 5,764] 5,007 [3,602 - 5,902] 4,409 [2,903 - 5,857] 3,056 [1,594 - 4,983] 4,273 [2,810 - 5,520]
Mean (SD) 4,255.30 (2,292.07) 4,511.00 (2,483.23) 4,411.34 (2,235.63) 3,356.35 (2,102.01) 4,258.58 (2,161.56)
Range 374 to 10,950 397 to 9,291 387 to 10,983 365 to 9,143 371 to 10,298
Future observation - Median [Q25 - Q75] 979 [369 - 1,912] 1,006 [110 - 1,304] 1,067 [382 - 2,037] 1,016 [371 - 1,881] 1,167 [455 - 2,087]
Mean (SD) 1,276.14 (1,117.51) 1,105.93 (1,259.42) 1,349.37 (1,138.34) 1,267.46 (1,044.65) 1,413.73 (1,159.57)
Range 1 to 5,240 15 to 4,036 1 to 4,849 37 to 4,052 20 to 4,377
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 4 [3 - 18] 28 [13 - 34] 265 [93 - 681] 28 [20 - 50]
Mean (SD) 9.06 (19.89) 20.47 (31.38) 60.80 (166.15) 431.98 (468.66) 81.92 (195.95)
Range 1 to 645 1 to 95 2 to 1,937 7 to 2,051 3 to 1,579
Number of visits in the year prior - Median [Q25 - Q75] 34.00 [24.00 - 48.00] 57.00 [41.00 - 74.50] 33.00 [22.00 - 46.00] 37.00 [28.25 - 54.75] 35.50 [26.25 - 56.00]
Mean (SD) 37.98 (19.93) 60.93 (25.58) 36.24 (19.69) 44.91 (25.36) 42.65 (22.57)
Range 0.00 to 141.00 30.00 to 124.00 0.00 to 129.00 18.00 to 136.00 0.00 to 125.00
Medications in the year prior D dermatologicals N (%) 679 (43.92%) 7 (46.67%) 415 (41.83%) 24 (44.44%) 103 (45.58%)
N nervous system N (%) 1,300 (84.09%) 12 (80.00%) 781 (78.73%) 47 (87.04%) 215 (95.13%)
R respiratory system N (%) 600 (38.81%) 10 (66.67%) 396 (39.92%) 26 (48.15%) 107 (47.35%)
S sensory organs N (%) 423 (27.36%) - 270 (27.22%) 18 (33.33%) 54 (23.89%)
A alimentary tract and metabolism N (%) 1,250 (80.85%) 15 (100.00%) 794 (80.04%) 45 (83.33%) 194 (85.84%)
B blood and blood forming organs N (%) 680 (43.98%) 5 (33.33%) 395 (39.82%) 23 (42.59%) 96 (42.48%)
P antiparasitic products insecticides and repellents N (%) 119 (7.70%) - 92 (9.27%) 5 (9.26%) 23 (10.18%)
J antiinfectives for systemic use N (%) 741 (47.93%) 14 (93.33%) 574 (57.86%) 35 (64.81%) 130 (57.52%)
G genito urinary system and sex hormones N (%) 299 (19.34%) 7 (46.67%) 149 (15.02%) 13 (24.07%) 40 (17.70%)
M musculo skeletal system N (%) 629 (40.69%) 12 (80.00%) 460 (46.37%) 23 (42.59%) 137 (60.62%)
V various N (%) 208 (13.45%) - 125 (12.60%) - 23 (10.18%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 426 (27.55%) 11 (73.33%) 274 (27.62%) 17 (31.48%) 85 (37.61%)
L antineoplastic and immunomodulating agents N (%) 69 (4.46%) - 40 (4.03%) 0 (0.00%) 20 (8.85%)
C cardiovascular system N (%) 1,306 (84.48%) 12 (80.00%) 849 (85.58%) 52 (96.30%) 195 (86.28%)
Conditions any time prior Diseases of the nervous system N (%) 394 (25.49%) 5 (33.33%) 241 (24.29%) 22 (40.74%) 75 (33.19%)
Certain conditions originating in the perinatal period N (%) 75 (4.85%) - 47 (4.74%) 20 (37.04%) 9 (3.98%)
Certain infectious and parasitic diseases N (%) 788 (50.97%) 11 (73.33%) 508 (51.21%) 40 (74.07%) 128 (56.64%)
Mental and behavioural disorders N (%) 87 (5.63%) - 42 (4.23%) 5 (9.26%) 14 (6.19%)
Pregnancy childbirth and the puerperium N (%) 31 (2.01%) - 12 (1.21%) 0 (0.00%) -
Endocrine nutritional and metabolic diseases N (%) 132 (8.54%) - 67 (6.75%) 24 (44.44%) 17 (7.52%)
Neoplasms N (%) 116 (7.50%) - 70 (7.06%) - 23 (10.18%)
Diseases of the digestive system N (%) 228 (14.75%) - 152 (15.32%) 8 (14.81%) 39 (17.26%)
Diseases of the circulatory system N (%) 520 (33.64%) 10 (66.67%) 361 (36.39%) 32 (59.26%) 89 (39.38%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 1,505 (97.35%) 15 (100.00%) 967 (97.48%) 54 (100.00%) 222 (98.23%)
Diseases of the skin and subcutaneous tissue N (%) 402 (26.00%) 5 (33.33%) 261 (26.31%) 13 (24.07%) 72 (31.86%)
Injury poisoning and certain other consequences of external causes N (%) 763 (49.35%) 12 (80.00%) 528 (53.23%) 32 (59.26%) 131 (57.96%)
Diseases of the ear and mastoid process N (%) 90 (5.82%) - 54 (5.44%) - 19 (8.41%)
Diseases of the genitourinary system N (%) 288 (18.63%) 7 (46.67%) 191 (19.25%) 15 (27.78%) 43 (19.03%)
Diseases of the respiratory system N (%) 270 (17.46%) 8 (53.33%) 228 (22.98%) 15 (27.78%) 62 (27.43%)
Congenital malformations deformations and chromosomal abnormalities N (%) - 0 (0.00%) 5 (0.50%) 0 (0.00%) -
Codes for special purposes N (%) 310 (20.05%) 5 (33.33%) 197 (19.86%) 19 (35.19%) 56 (24.78%)
Diseases of the musculoskeletal system and connective tissue N (%) 601 (38.87%) 6 (40.00%) 404 (40.73%) 22 (40.74%) 112 (49.56%)
Diseases of the eye and adnexa N (%) 232 (15.01%) - 161 (16.23%) 16 (29.63%) 31 (13.72%)
Factors influencing health status and contact with health services N (%) 1,505 (97.35%) 15 (100.00%) 970 (97.78%) 54 (100.00%) 222 (98.23%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 165 (10.67%) 6 (40.00%) 119 (12.00%) 5 (9.26%) 34 (15.04%)
External causes of morbidity and mortality N (%) 107 (6.92%) 6 (40.00%) 81 (8.17%) - 25 (11.06%)
Male Number records - N 896 16 523 52 101
Number subjects - N 648 14 423 52 93
Cohort start date - Median [Q25 - Q75] 2014-03-20 [2012-02-14 - 2017-01-10] 2014-01-29 [2012-02-13 - 2015-08-13] 2014-05-02 [2012-04-26 - 2017-04-06] 2014-01-22 [2011-10-08 - 2016-12-07] 2013-09-16 [2012-04-26 - 2016-01-25]
Range 2010-01-04 to 2019-12-27 2010-04-07 to 2018-10-12 2010-02-01 to 2019-12-24 2010-01-04 to 2019-12-03 2010-01-29 to 2019-11-01
Cohort end date - Median [Q25 - Q75] 2014-04-02 [2012-02-20 - 2017-01-16] 2014-05-10 [2012-04-16 - 2015-08-19] 2014-07-03 [2012-06-19 - 2017-06-15] 2015-04-02 [2013-01-25 - 2017-11-06] 2014-01-19 [2012-06-14 - 2016-03-06]
Range 2010-01-08 to 2020-01-02 2010-04-12 to 2018-10-14 2010-02-18 to 2023-01-31 2010-04-05 to 2024-02-01 2010-02-01 to 2020-08-20
Age - Median [Q25 - Q75] 84 [82 - 88] 85 [83 - 86] 84 [82 - 87] 82 [80 - 84] 84 [82 - 87]
Mean (SD) 85.03 (4.16) 84.56 (2.90) 84.80 (4.12) 82.42 (2.71) 84.75 (3.73)
Range 80 to 106 80 to 90 80 to 105 80 to 92 80 to 95
Age group 80 to 150 N (%) 896 (100.00%) 16 (100.00%) 523 (100.00%) 52 (100.00%) 101 (100.00%)
Sex Male N (%) 896 (100.00%) 16 (100.00%) 523 (100.00%) 52 (100.00%) 101 (100.00%)
Prior observation - Median [Q25 - Q75] 4,381 [2,765 - 5,744] 3,560 [2,614 - 4,464] 4,726 [3,214 - 5,956] 4,158 [1,852 - 5,608] 4,686 [3,684 - 5,653]
Mean (SD) 4,403.66 (2,300.20) 3,940.94 (2,088.33) 4,684.05 (2,256.19) 4,108.88 (2,401.43) 4,801.04 (1,959.25)
Range 371 to 10,659 1,276 to 9,486 365 to 10,900 432 to 8,767 419 to 10,126
Future observation - Median [Q25 - Q75] 848 [341 - 1,679] 772 [337 - 1,594] 966 [372 - 1,818] 1,275 [536 - 2,077] 846 [370 - 1,368]
Mean (SD) 1,129.67 (1,002.38) 1,131.25 (955.92) 1,186.50 (989.92) 1,407.25 (1,083.44) 984.44 (791.05)
Range 0 to 5,266 121 to 3,259 2 to 5,215 43 to 4,137 17 to 4,005
Days in cohort - Median [Q25 - Q75] 7 [7 - 7] 6 [3 - 28] 28 [9 - 28] 116 [53 - 524] 28 [28 - 46]
Mean (SD) 8.23 (7.59) 46.38 (91.55) 42.97 (141.35) 416.92 (623.10) 77.96 (154.17)
Range 1 to 128 3 to 342 2 to 2,347 25 to 2,919 4 to 995
Number of visits in the year prior - Median [Q25 - Q75] 34.00 [23.00 - 50.00] 59.50 [41.00 - 72.75] 35.00 [24.00 - 50.00] 35.00 [27.50 - 51.25] 40.00 [28.00 - 56.00]
Mean (SD) 39.17 (22.07) 56.06 (19.70) 39.24 (21.67) 40.77 (22.59) 44.59 (23.73)
Range 1.00 to 120.00 27.00 to 85.00 0.00 to 113.00 3.00 to 101.00 3.00 to 129.00
Medications in the year prior D dermatologicals N (%) 431 (48.10%) 12 (75.00%) 238 (45.51%) 21 (40.38%) 54 (53.47%)
N nervous system N (%) 691 (77.12%) 15 (93.75%) 389 (74.38%) 48 (92.31%) 92 (91.09%)
R respiratory system N (%) 400 (44.64%) 12 (75.00%) 193 (36.90%) 26 (50.00%) 64 (63.37%)
S sensory organs N (%) 216 (24.11%) 5 (31.25%) 134 (25.62%) 12 (23.08%) 29 (28.71%)
A alimentary tract and metabolism N (%) 660 (73.66%) 14 (87.50%) 392 (74.95%) 48 (92.31%) 80 (79.21%)
B blood and blood forming organs N (%) 424 (47.32%) 9 (56.25%) 241 (46.08%) 19 (36.54%) 50 (49.50%)
P antiparasitic products insecticides and repellents N (%) 68 (7.59%) - 43 (8.22%) 0 (0.00%) 11 (10.89%)
J antiinfectives for systemic use N (%) 340 (37.95%) 14 (87.50%) 259 (49.52%) 21 (40.38%) 55 (54.46%)
G genito urinary system and sex hormones N (%) 340 (37.95%) 6 (37.50%) 197 (37.67%) 26 (50.00%) 43 (42.57%)
M musculo skeletal system N (%) 304 (33.93%) 8 (50.00%) 186 (35.56%) 12 (23.08%) 62 (61.39%)
V various N (%) 124 (13.84%) 6 (37.50%) 55 (10.52%) 8 (15.38%) 11 (10.89%)
H systemic hormonal preparations excl sex hormones and insulins N (%) 164 (18.30%) 14 (87.50%) 103 (19.69%) 13 (25.00%) 29 (28.71%)
L antineoplastic and immunomodulating agents N (%) 58 (6.47%) - 40 (7.65%) 5 (9.62%) 12 (11.88%)
C cardiovascular system N (%) 757 (84.49%) 16 (100.00%) 445 (85.09%) 50 (96.15%) 88 (87.13%)
Conditions any time prior Diseases of the nervous system N (%) 226 (25.22%) - 136 (26.00%) 15 (28.85%) 31 (30.69%)
Certain conditions originating in the perinatal period N (%) 62 (6.92%) - 27 (5.16%) 17 (32.69%) 8 (7.92%)
Certain infectious and parasitic diseases N (%) 484 (54.02%) 10 (62.50%) 298 (56.98%) 30 (57.69%) 58 (57.43%)
Mental and behavioural disorders N (%) 52 (5.80%) 0 (0.00%) 25 (4.78%) - -
Pregnancy childbirth and the puerperium N (%) - 0 (0.00%) - 0 (0.00%) -
Endocrine nutritional and metabolic diseases N (%) 98 (10.94%) - 46 (8.80%) 19 (36.54%) 9 (8.91%)
Neoplasms N (%) 92 (10.27%) - 58 (11.09%) - 14 (13.86%)
Diseases of the digestive system N (%) 136 (15.18%) - 93 (17.78%) 12 (23.08%) 23 (22.77%)
Diseases of the circulatory system N (%) 299 (33.37%) 11 (68.75%) 191 (36.52%) 26 (50.00%) 38 (37.62%)
Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified N (%) 873 (97.43%) 16 (100.00%) 513 (98.09%) 52 (100.00%) 98 (97.03%)
Diseases of the skin and subcutaneous tissue N (%) 252 (28.12%) - 137 (26.20%) 12 (23.08%) 30 (29.70%)
Injury poisoning and certain other consequences of external causes N (%) 455 (50.78%) 13 (81.25%) 270 (51.63%) 24 (46.15%) 56 (55.45%)
Diseases of the ear and mastoid process N (%) 56 (6.25%) - 31 (5.93%) - 7 (6.93%)
Diseases of the genitourinary system N (%) 145 (16.18%) - 74 (14.15%) 7 (13.46%) 18 (17.82%)
Diseases of the respiratory system N (%) 176 (19.64%) 11 (68.75%) 121 (23.14%) 11 (21.15%) 29 (28.71%)
Congenital malformations deformations and chromosomal abnormalities N (%) 5 (0.56%) 0 (0.00%) 6 (1.15%) - 0 (0.00%)
Codes for special purposes N (%) 353 (39.40%) 9 (56.25%) 210 (40.15%) 28 (53.85%) 31 (30.69%)
Diseases of the musculoskeletal system and connective tissue N (%) 329 (36.72%) 5 (31.25%) 204 (39.01%) 19 (36.54%) 43 (42.57%)
Diseases of the eye and adnexa N (%) 150 (16.74%) - 89 (17.02%) 17 (32.69%) 17 (16.83%)
Factors influencing health status and contact with health services N (%) 876 (97.77%) 16 (100.00%) 514 (98.28%) 52 (100.00%) 100 (99.01%)
Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism N (%) 96 (10.71%) 5 (31.25%) 48 (9.18%) 9 (17.31%) 15 (14.85%)
External causes of morbidity and mortality N (%) 52 (5.80%) 5 (31.25%) 27 (5.16%) 6 (11.54%) 8 (7.92%)

Create a simple table

result |>
  omopgenerics::filterSettings(result_type == "summarise_characteristics") |>
  omopgenerics::filterGroup(cohort_name == "amoxicillin") |>
  omopgenerics::filterStrata(age_group == "overall") |>
  dplyr::filter(estimate_name %in% c("percentage", "median")) |>
  CohortCharacteristics::tableCharacteristics(
    header = c("cdm_name", "sex"), 
    type = "flextable", 
    hide = c("cohort_name", "age_group", "window", "table", "value", "table_name")
  )

Variable name

Variable level

Estimate name

CDM name

CPRD GOLD

Sex

overall

Female

Male

Cohort start date

-

median

2013-10-17

2013-10-25

2013-10-08

Cohort end date

-

median

2013-10-23

2013-11-03

2013-10-14

Age

-

median

45

45

45

Age group

0 to 19

percentage

23.74

20.27

28.44

20 to 39

percentage

19.63

22.29

16.03

40 to 59

percentage

25.30

26.08

24.26

60 to 79

percentage

23.22

22.43

24.29

80 to 150

percentage

8.10

8.93

6.99

Sex

Female

percentage

57.45

100.00

-

Male

percentage

42.55

-

100.00

Prior observation

-

median

3,413

3,499

3,302

Future observation

-

median

1,888

1,881

1,899

Days in cohort

-

median

7

7

7

Number of visits in the year prior

-

median

13.00

15.00

11.00

Medications in the year prior

D dermatologicals

percentage

32.39

33.71

30.62

N nervous system

percentage

46.15

50.50

40.27

R respiratory system

percentage

36.19

37.73

34.10

S sensory organs

percentage

12.97

13.54

12.21

A alimentary tract and metabolism

percentage

41.70

44.09

38.47

B blood and blood forming organs

percentage

17.51

19.74

14.50

P antiparasitic products insecticides and repellents

percentage

4.73

5.68

3.44

J antiinfectives for systemic use

percentage

36.99

41.93

30.32

G genito urinary system and sex hormones

percentage

22.90

28.69

15.08

M musculo skeletal system

percentage

24.67

27.21

21.24

V various

percentage

5.62

6.85

3.95

H systemic hormonal preparations excl sex hormones and insulins

percentage

11.82

14.42

8.31

L antineoplastic and immunomodulating agents

percentage

3.42

4.32

2.20

C cardiovascular system

percentage

38.15

37.91

38.47

Conditions any time prior

Diseases of the nervous system

percentage

19.77

21.51

17.42

Certain conditions originating in the perinatal period

percentage

2.82

2.40

3.38

Certain infectious and parasitic diseases

percentage

44.01

45.79

41.61

Mental and behavioural disorders

percentage

3.98

4.63

3.10

Pregnancy childbirth and the puerperium

percentage

3.43

5.75

0.30

Endocrine nutritional and metabolic diseases

percentage

5.19

5.34

4.98

Neoplasms

percentage

4.24

4.44

3.97

Diseases of the digestive system

percentage

13.58

14.33

12.56

Diseases of the circulatory system

percentage

27.32

27.80

26.67

Symptoms signs and abnormal clinical and laboratory findings not elsewhere classified

percentage

84.76

87.77

80.70

Diseases of the skin and subcutaneous tissue

percentage

24.60

25.02

24.04

Injury poisoning and certain other consequences of external causes

percentage

37.63

39.71

34.82

Diseases of the ear and mastoid process

percentage

5.73

5.85

5.57

Diseases of the genitourinary system

percentage

10.94

14.19

6.57

Diseases of the respiratory system

percentage

17.80

17.40

18.35

Congenital malformations deformations and chromosomal abnormalities

percentage

0.61

0.44

0.85

Codes for special purposes

percentage

15.15

13.94

16.78

Diseases of the musculoskeletal system and connective tissue

percentage

32.66

33.68

31.27

Diseases of the eye and adnexa

percentage

8.83

8.84

8.81

Factors influencing health status and contact with health services

percentage

85.55

88.55

81.51

Diseases of the blood and blood forming organs and certain disorders involving the immune mechanism

percentage

7.66

8.31

6.77

External causes of morbidity and mortality

percentage

2.63

3.07

2.04

Plot Output Options

💡 Which one to use?

  • ggplot2 for everything (mainly static reports, but also useful for shiny apps).
  • plotly mainly for interactive output (shiny apps).

Create a simple plot

result |>
  omopgenerics::filterSettings(result_type == "summarise_proportion_of_patients_covered") |>
  omopgenerics::filterStrata(sex == "overall" & age_group != "overall") |>
  DrugUtilisation::plotProportionOfPatientsCovered(colour = "age_group")

Your turn

15 minutes

Choose one of the ingredients: and create a ‘Microsoft Word’ report that shows:

  • Number of ingredient users

  • Characteristics of new users

  • Proportion of patients covered

  • Prevalence

Shiny apps

Shiny apps are a way to display results interactively, it is very useful when you have many results.

Example shiny: https://master-data-scientist.shinyapps.io/Flight-Dashboard/

Shiny apps have two parts:

  • The User Interface (ui): is the visualisation part, it defines what the user will see: different buttons, panels, plots, tables…

  • The server: is the part that calculates the interactive visualisations and outputs to display.

Shiny apps

Generaly we would create a shiny app with 3 files (ui.R, server.R, and global.R):

  • global.R It would include code that will be executed at the beginning of the creation of the shiny app. Usually used to define some parameters of preproces some data.
  • ui.R It contains the code of the user interface part.
  • server.R It contains the code of the server part. The server is a function with the following arguments (input, output, and session).

My first shiny app

New Blank File -> Shiny Web App… -> MyFirstShiny + tick multiple file

If you click Run App in the top right.

OmopViewer

OmopViewer it creates the shiny for you. It will create the scripts (‘shiny.R’, ‘server.R’, and ‘global.R’) given a summarised_result standard format.

The idea is that OmopViewer will create for you the stucture and 90% of the content and then you can cusomise it a bit more.

OmopViewer empty shiny

OmopViewer::exportStaticApp(
  result = omopgenerics::emptySummarisedResult(),
  directory = here::here()
)

OmopViewer add results

result <- omopgenerics::importSummarisedResult(here::here("data"))
OmopViewer::exportStaticApp(
  result = result,
  directory = here::here()
)

exportStaticApp inputs

Let’s see the other inputs:

  • result A summarised_result object.

  • directory Directory to create the shiny.

  • logo Name of a logo or path to a logo. If NULL no logo is included. Only svg format allowed for the moment.

  • title title of the shiny

  • background Whether to include a background panel. Background panel content will be controlled from the generated background.md file.

  • summary Whether to include a panel with a summary of content in the ‘result’.

  • panelStructure A named list of panel indetifiers to organise them in dropdown menus.

exportStaticApp inputs

  • panelDetails A named list to provide details for each one of the panels, such as: result_id, result_type, title, icon, output_id, … Name of each element must be the identifier name of ‘panelStructure’.

  • theme Specify the theme for the Shiny application. You can either select a predefined theme provided by the package (e.g., ‘“theme1”’), or define a custom theme using ‘bslib::bs_theme()’. If using a custom theme, it must be provided as a character string (e.g., ‘“bslib::bs_theme(bg = ’white’, fg = ‘black’)”’).

  • open Whether to open the shiny app project

Exercise 1

Let’s play with some of the inputs

  • logo: we will download a logo from the internet (e.g. random picture)

  • title: Let’s put a meaningful title.

  • summary: Let’s not display the summary tab (summary = FALSE).

Exercise 2

Let’s edit the resultant shiny

  1. Edit the background.md file (not much as we will overwrite this shiny again).

  2. Add the following statement in the server and let’s search for a theme that we like:

bslib::bs_themer()

Let’s edit the shiny stucture

With the panelDetails and panelStructure we can edit the structure of the shiny.

omopgenerics::settings(result) |> 
  print(n = 100)
# A tibble: 43 × 24
   result_id result_type      package_name package_version group strata additional min_cell_count analysis_complete_da…¹
       <int> <chr>            <chr>        <chr>           <chr> <chr>  <chr>      <chr>          <chr>                 
 1         1 summarise_cohor… CohortChara… 0.4.0           coho… "reas… reason_id  5              <NA>                  
 2         2 summarise_cohor… CohortChara… 0.4.0           coho… "reas… reason_id  5              <NA>                  
 3         3 summarise_cohor… CohortChara… 0.4.0           coho… "reas… reason_id  5              <NA>                  
 4         4 summarise_cohor… CohortChara… 0.4.0           coho… "reas… reason_id  5              <NA>                  
 5         5 summarise_cohor… CohortChara… 0.4.0           coho… "reas… reason_id  5              <NA>                  
 6         6 summarise_propo… DrugUtilisa… 0.8.2           coho… "age_… time       5              <NA>                  
 7         7 summarise_chara… CohortChara… 0.4.0           coho… "age_… table &&&… 5              <NA>                  
 8         8 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
 9         9 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
10        10 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
11        11 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
12        12 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
13        13 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
14        14 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
15        15 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
16        16 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
17        17 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
18        18 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
19        19 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
20        20 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
21        21 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
22        22 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
23        23 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
24        24 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
25        25 prevalence       IncidencePr… 1.0.0           deno… ""     prevalenc… 5              TRUE                  
26        26 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
27        27 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
28        28 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
29        29 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
30        30 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
31        31 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
32        32 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
33        33 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
34        34 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
35        35 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
36        36 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
37        37 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
38        38 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
39        39 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
40        40 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
41        41 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
42        42 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
43        43 prevalence_attr… IncidencePr… 1.0.0           deno… "reas… reason_id  5              TRUE                  
# ℹ abbreviated name: ¹​analysis_complete_database_intervals
# ℹ 15 more variables: analysis_full_contribution <chr>, analysis_type <chr>, cohort_definition_id <chr>,
#   cohort_table_name <chr>, denominator_age_group <chr>, denominator_days_prior_observation <chr>,
#   denominator_end_date <chr>, denominator_sex <chr>, denominator_start_date <chr>,
#   denominator_target_cohort_name <chr>, denominator_time_at_risk <chr>, gap_era <chr>, prior_drug_observation <chr>,
#   prior_use_washout <chr>, table_name <chr>

Let’s edit the shiny stucture

With the panelDetails and panelStructure we can edit the structure of the shiny.

panelStructure = list(
  "attrition",
  "ppc",
  "characterisation",
  "Prevalence" = list("prevalence", "prevalence_attrition")
)
OmopViewer::exportStaticApp(
  result = result,
  directory = here::here(), 
  logo = 'hds',
  title = 'My study', 
  background = TRUE, 
  summary = FALSE, 
  panelStructure = panelStructure,
  theme = 'bslib::bs_theme(bootswatch = "quartz")'
)

Exercise 3

Let’s customise this shiny:

  • Add or remove a couple of buttons

  • Edit the background section

OmopViewer dynamic mode

OmopViewer has a dynamic mode where we do not need to create the shiny app files, but then we do not have any control on the shiny appearance.

options(shiny.maxRequestSize = 100 * 1024^2)
OmopViewer::launchDynamicApp()

Thanks

How can we better help?