Required packages

install.packages("IncidencePrevalence")

generateDenominatorCohortSet()

cdm <- mockIncidencePrevalenceRef(sampleSize = 50000)

cdm <- generateDenominatorCohortSet(cdm, name = "dpop")

cdm$dpop %>%
  glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [eburn@Windows 10 x64:R 4.4.0/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1…
$ subject_id           <int> 1, 3, 7, 11, 14, 21, 29, 32, 33, 36, 37, 41, 42, …
$ cohort_start_date    <date> 1949-10-29, 1977-03-02, 1994-07-10, 1945-08-21, …
$ cohort_end_date      <date> 1957-03-20, 1982-06-05, 1996-11-16, 1951-02-11, …

generateDenominatorCohortSet()

cdm <- generateDenominatorCohortSet(
  cdm = cdm, name = "dpop",
  cohortDateRange = as.Date(c("2008-01-01", "2012-01-01"))
)

cdm$dpop %>%
  glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [eburn@Windows 10 x64:R 4.4.0/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1…
$ subject_id           <int> 33, 41, 52, 59, 69, 76, 79, 89, 122, 141, 151, 16…
$ cohort_start_date    <date> 2008-01-01, 2008-01-01, 2008-01-01, 2008-01-01, …
$ cohort_end_date      <date> 2008-08-04, 2012-01-01, 2011-10-24, 2012-01-01, …

generateDenominatorCohortSet()

cohortCount(cdm$dpop)
# A tibble: 1 × 3
  cohort_definition_id number_records number_subjects
                 <int>          <int>           <int>
1                    1           3575            3575
settings(cdm$dpop)
# A tibble: 1 × 10
  cohort_definition_id cohort_name        age_group sex   days_prior_observation
                 <int> <chr>              <chr>     <chr>                  <dbl>
1                    1 denominator_cohor… 0 to 150  Both                       0
# ℹ 5 more variables: start_date <date>, end_date <date>, time_at_risk <chr>,
#   target_cohort_definition_id <int>, target_cohort_name <chr>

generateDenominatorCohortSet()

attrition(cdm$dpop)
# A tibble: 8 × 7
  cohort_definition_id number_records number_subjects reason_id reason          
                 <int>          <int>           <int>     <int> <chr>           
1                    1          50000           50000         1 Starting popula…
2                    1          50000           50000         2 Missing year of…
3                    1          50000           50000         3 Missing sex     
4                    1          50000           50000         4 Cannot satisfy …
5                    1           3575            3575         5 No observation …
6                    1           3575            3575         6 Doesn't satisfy…
7                    1           3575            3575         7 Prior history r…
8                    1           3575            3575        10 No observation …
# ℹ 2 more variables: excluded_records <int>, excluded_subjects <int>

generateDenominatorCohortSet()

cdm <- generateDenominatorCohortSet(
  cdm = cdm, name = "dpop",
  cohortDateRange = as.Date(c("2008-01-01", "2012-01-01")),
  ageGroup = list(
    c(0, 49),
    c(50, 100)
  ),
  sex = c("Male", "Female")
)

cdm$dpop %>%
  glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [eburn@Windows 10 x64:R 4.4.0/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1…
$ subject_id           <int> 59, 89, 200, 208, 396, 501, 579, 581, 615, 642, 6…
$ cohort_start_date    <date> 2008-01-01, 2008-01-01, 2008-01-01, 2008-01-01, …
$ cohort_end_date      <date> 2012-01-01, 2009-08-06, 2010-12-23, 2012-01-01, …

generateDenominatorCohortSet()

cdm <- generateDenominatorCohortSet(
  cdm = cdm, name = "dpop",
  cohortDateRange = as.Date(c("2008-01-01", "2012-01-01")),
  ageGroup = list(
    c(0, 49),
    c(50, 100)
  ),
  sex = c("Male", "Female"),
  daysPriorObservation= c(0, 180)
)

cdm$dpop %>%
  glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [eburn@Windows 10 x64:R 4.4.0/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1…
$ subject_id           <int> 59, 89, 200, 208, 396, 501, 579, 581, 615, 642, 6…
$ cohort_start_date    <date> 2008-01-01, 2008-01-01, 2008-01-01, 2008-01-01, …
$ cohort_end_date      <date> 2012-01-01, 2009-08-06, 2010-12-23, 2012-01-01, …

generateDenominatorCohortSet()

settings(cdm$dpop)
# A tibble: 8 × 10
  cohort_definition_id cohort_name        age_group sex   days_prior_observation
                 <int> <chr>              <chr>     <chr>                  <dbl>
1                    1 denominator_cohor… 0 to 49   Male                       0
2                    2 denominator_cohor… 0 to 49   Male                     180
3                    3 denominator_cohor… 0 to 49   Fema…                      0
4                    4 denominator_cohor… 0 to 49   Fema…                    180
5                    5 denominator_cohor… 50 to 100 Male                       0
6                    6 denominator_cohor… 50 to 100 Male                     180
7                    7 denominator_cohor… 50 to 100 Fema…                      0
8                    8 denominator_cohor… 50 to 100 Fema…                    180
# ℹ 5 more variables: start_date <date>, end_date <date>, time_at_risk <chr>,
#   target_cohort_definition_id <int>, target_cohort_name <chr>

generateDenominatorCohortSet()

cohortCount(cdm$dpop)
# A tibble: 8 × 3
  cohort_definition_id number_records number_subjects
                 <int>          <int>           <int>
1                    1            973             973
2                    2            959             959
3                    3            902             902
4                    4            890             890
5                    5            933             933
6                    6            925             925
7                    7            922             922
8                    8            900             900

generateDenominatorCohortSet()

attrition(cdm$dpop) %>%
  filter(cohort_definition_id == 1)
# A tibble: 9 × 7
  cohort_definition_id number_records number_subjects reason_id reason          
                 <int>          <int>           <int>     <int> <chr>           
1                    1          50000           50000         1 Starting popula…
2                    1          50000           50000         2 Missing year of…
3                    1          50000           50000         3 Missing sex     
4                    1          50000           50000         4 Cannot satisfy …
5                    1           3575            3575         5 No observation …
6                    1           3575            3575         6 Doesn't satisfy…
7                    1           3575            3575         7 Prior history r…
8                    1           1822            1822         8 Not Male        
9                    1            973             973        10 No observation …
# ℹ 2 more variables: excluded_records <int>, excluded_subjects <int>

generateDenominatorCohortSet()

# get some people who are in more than one cohort
ids <- cdm$dpop %>% 
  group_by(subject_id) %>% 
  tally() %>% 
  collect() %>% 
  arrange(desc(n)) %>% 
  head(4) %>% 
  pull("subject_id")

generateDenominatorCohortSet()

dpop <- cdm$dpop %>%
  collect() %>%
  left_join(settings(cdm$dpop),
            by = "cohort_definition_id") %>% 
  mutate(cohort_definition_id=as.character(cohort_definition_id))

plot <- dpop %>%
  filter(subject_id %in% ids) %>%
  pivot_longer(cols = c(
    "cohort_start_date",
    "cohort_end_date"
  )) %>%
  ggplot(aes(x = as.character(subject_id), y = value, colour = cohort_definition_id, group = subject_id)) +
  facet_grid(sex + days_prior_observation ~ ., space = "free_y") +
  geom_point(position = position_dodge(width = 0.5)) +
  geom_line(position = position_dodge(width = 0.5)) +
  theme_bw() +
  theme(legend.position = "top") +
  ylab("Year") +
  coord_flip()

generateDenominatorCohortSet()

plot

Adding (time-invariant) variables for stratification

If later we want to estimate incidence or prevalence stratified for some time-invariant characteristic, we will need to add a variable to our denominator cohort table.

cdm$dpop <- cdm$dpop %>% 
  mutate(group = if_else(as.numeric(subject_id)  < 20, "first", "second")) 

cdm$dpop |> 
  glimpse()
Rows: ??
Columns: 5
Database: DuckDB v1.0.0 [eburn@Windows 10 x64:R 4.4.0/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1…
$ subject_id           <int> 59, 89, 200, 208, 396, 501, 579, 581, 615, 642, 6…
$ cohort_start_date    <date> 2008-01-01, 2008-01-01, 2008-01-01, 2008-01-01, …
$ cohort_end_date      <date> 2012-01-01, 2009-08-06, 2010-12-23, 2012-01-01, …
$ group                <chr> "second", "second", "second", "second", "second",…

generateTargetDenominatorCohortSet()

When we want to stratify on a time-varying characteristic, we will do this by first creating a cohort for it. Once we have the cohort we will will use it when creating our denominator cohort.

generateTargetDenominatorCohortSet()

personTable <- tibble(
  person_id = c("1", "2", "3", "4", "5"),
  gender_concept_id = c(rep("8507", 2), rep("8532", 3)),
  year_of_birth = 2000,
  month_of_birth = 06,
  day_of_birth = 01
)
observationPeriodTable <- tibble(
  observation_period_id = "1",
  person_id = c("1", "2", "3", "4", "5"),
  observation_period_start_date = c(
    as.Date("2010-12-19"),
    as.Date("2005-04-01"),
    as.Date("2009-04-10"),
    as.Date("2010-08-20"),
    as.Date("2010-01-01")
  ),
  observation_period_end_date = c(
    as.Date("2011-06-19"),
    as.Date("2005-11-29"),
    as.Date("2016-01-02"),
    as.Date("2011-12-11"),
    as.Date("2015-06-01")
  )
)

acute_asthma <- tibble(
  cohort_definition_id = rep("1", 5),
  subject_id = c("3", "3", "5", "5", "2"),
  cohort_start_date = c(
    as.Date("2012-01-01"),
    as.Date("2015-06-01"),
    as.Date("2014-10-01"),
    as.Date("2010-06-01"),
    as.Date("2005-08-20")
  ),
  cohort_end_date = c(
    as.Date("2013-01-01"),
    as.Date("2015-12-31"),
    as.Date("2015-04-01"),
    as.Date("2010-06-01"),
    as.Date("2005-09-20")
  )
)

# mock database
cdm <- mockIncidencePrevalenceRef(
  personTable = personTable,
  observationPeriodTable = observationPeriodTable,
  targetCohortTable = acute_asthma
)

generateTargetDenominatorCohortSet()

cdm <- generateTargetDenominatorCohortSet(
  cdm = cdm, 
  name = "denominator_acute_asthma",
  targetCohortTable = "target"
)

cdm$denominator_acute_asthma |> 
  dplyr::glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [eburn@Windows 10 x64:R 4.4.0/:memory:]
$ cohort_definition_id <int> 1, 1, 1, 1, 1
$ subject_id           <chr> "3", "3", "5", "5", "2"
$ cohort_start_date    <date> 2012-01-01, 2015-06-01, 2014-10-01, 2010-06-01, 2…
$ cohort_end_date      <date> 2013-01-01, 2015-12-31, 2015-04-01, 2010-06-01, 2…

generateTargetDenominatorCohortSet()

We can add demographic requirements like before. But it is important to note that these are applied at the cohort start date of the target cohort.

cdm <- generateTargetDenominatorCohortSet(
  cdm = cdm, 
  name = "denominator_acute_asthma_2",
  ageGroup = list(c(11, 15)),
  sex = "Female",
  daysPriorObservation = 0,
  targetCohortTable = "target"
)
cdm$denominator_acute_asthma_2 |> 
  dplyr::glimpse()
Rows: ??
Columns: 4
Database: DuckDB v1.0.0 [eburn@Windows 10 x64:R 4.4.0/:memory:]
$ cohort_definition_id <int> 1, 1, 1
$ subject_id           <chr> "3", "3", "5"
$ cohort_start_date    <date> 2012-01-01, 2015-06-01, 2014-10-01
$ cohort_end_date      <date> 2013-01-01, 2015-12-31, 2015-04-01

estimateIncidence()

cdm <- mockIncidencePrevalenceRef(
  sampleSize = 50000,
  outPre = 0.5
)

cdm <- generateDenominatorCohortSet(
  cdm = cdm, name = "denominator",
  cohortDateRange = as.Date(c("2008-01-01", "2012-01-01")),
  ageGroup = list(
    c(0, 30),
    c(31, 50),
    c(51, 70),
    c(71, 100)
  )
)
inc <- estimateIncidence(
  cdm = cdm,
  denominatorTable = "denominator",
  outcomeTable = "outcome",
  interval = "years",
  outcomeWashout = Inf,
  repeatedEvents = FALSE
)

estimateIncidence()

inc %>%
  glimpse()
Rows: 288
Columns: 13
$ result_id        <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
$ cdm_name         <chr> "mock", "mock", "mock", "mock", "mock", "mock", "mock…
$ group_name       <chr> "denominator_cohort_name", "denominator_cohort_name",…
$ group_level      <chr> "denominator_cohort_1", "denominator_cohort_1", "deno…
$ strata_name      <chr> "overall", "overall", "overall", "overall", "overall"…
$ strata_level     <chr> "overall", "overall", "overall", "overall", "overall"…
$ variable_name    <chr> "outcome_cohort_name", "outcome_cohort_name", "outcom…
$ variable_level   <chr> "cohort_1", "cohort_1", "cohort_1", "cohort_1", "coho…
$ estimate_name    <chr> "denominator_count", "outcome_count", "person_days", …
$ estimate_type    <chr> "integer", "integer", "numeric", "numeric", "numeric"…
$ estimate_value   <chr> "662", "63", "189075", "517.659", "12170.174", "9351.…
$ additional_name  <chr> "incidence_start_date &&& incidence_end_date", "incid…
$ additional_level <chr> "2008-01-01 &&& 2008-12-31", "2008-01-01 &&& 2008-12-…

estimateIncidence()

inc <- estimateIncidence(
  cdm = cdm,
  denominatorTable = "denominator",
  outcomeTable = "outcome",
  interval = c("Months"),
  outcomeWashout = c(0, 365),
  repeatedEvents = FALSE
)
inc %>%
  glimpse()
Rows: 3,040
Columns: 13
$ result_id        <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
$ cdm_name         <chr> "mock", "mock", "mock", "mock", "mock", "mock", "mock…
$ group_name       <chr> "denominator_cohort_name", "denominator_cohort_name",…
$ group_level      <chr> "denominator_cohort_1", "denominator_cohort_1", "deno…
$ strata_name      <chr> "overall", "overall", "overall", "overall", "overall"…
$ strata_level     <chr> "overall", "overall", "overall", "overall", "overall"…
$ variable_name    <chr> "outcome_cohort_name", "outcome_cohort_name", "outcom…
$ variable_level   <chr> "cohort_1", "cohort_1", "cohort_1", "cohort_1", "coho…
$ estimate_name    <chr> "denominator_count", "outcome_count", "person_days", …
$ estimate_type    <chr> "integer", "integer", "numeric", "numeric", "numeric"…
$ estimate_value   <chr> "766", NA, NA, NA, NA, NA, NA, "761", NA, NA, NA, NA,…
$ additional_name  <chr> "incidence_start_date &&& incidence_end_date", "incid…
$ additional_level <chr> "2008-01-01 &&& 2008-01-31", "2008-01-01 &&& 2008-01-…

estimateIncidence()

plot <- plotIncidence(inc,
              facet = "denominator_age_group")

estimateIncidence()

plot

estimateIncidence()

Database name Denominator cohort name Outcome cohort name Incidence start date Incidence end date Result type Package name Package version Analysis outcome washout Analysis repeated events Analysis interval Analysis complete database intervals Denominator age group Denominator sex Denominator days prior observation Denominator start date Denominator end date Denominator time at risk Denominator target cohort name Min cell count Estimate name
Denominator (N) Person-years Outcome (N) Incidence 100 person-years [95% CI]
mock denominator_cohort_1 cohort_1 2008-01-01 2008-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 766 <5 <5 <5 (<5 - <5)
2008-02-01 2008-02-29 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 761 <5 <5 <5 (<5 - <5)
2008-03-01 2008-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 758 62.81 7 11,144.90 (4,480.83 - 22,962.75)
2008-04-01 2008-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 742 59.32 7 11,800.21 (4,744.29 - 24,312.93)
2008-05-01 2008-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 723 <5 <5 <5 (<5 - <5)
2008-06-01 2008-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 718 57.90 7 12,089.18 (4,860.48 - 24,908.34)
2008-07-01 2008-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 706 <5 <5 <5 (<5 - <5)
2008-08-01 2008-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 706 58.66 6 10,228.78 (3,753.78 - 22,263.76)
2008-09-01 2008-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 695 56.20 8 14,234.12 (6,145.28 - 28,046.88)
2008-10-01 2008-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 690 <5 <5 <5 (<5 - <5)
2008-11-01 2008-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 679 <5 <5 <5 (<5 - <5)
2008-12-01 2008-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 678 56.12 8 14,255.17 (6,154.37 - 28,088.36)
2009-01-01 2009-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 668 55.59 7 12,592.42 (5,062.81 - 25,945.20)
2009-02-01 2009-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 656 49.40 6 12,146.73 (4,457.64 - 26,438.32)
2009-03-01 2009-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 648 <5 <5 <5 (<5 - <5)
2009-04-01 2009-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 649 52.01 7 13,458.69 (5,411.09 - 27,730.05)
2009-05-01 2009-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 645 52.99 9 16,983.06 (7,765.73 - 32,239.13)
2009-06-01 2009-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 631 50.56 6 11,867.79 (4,355.27 - 25,831.19)
2009-07-01 2009-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 616 51.49 6 11,652.07 (4,276.10 - 25,361.65)
2009-08-01 2009-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 614 <5 <5 <5 (<5 - <5)
2009-09-01 2009-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 612 49.27 5 10,148.16 (3,295.08 - 23,682.43)
2009-10-01 2009-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 604 <5 <5 <5 (<5 - <5)
2009-11-01 2009-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 603 <5 <5 <5 (<5 - <5)
2009-12-01 2009-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 599 <5 <5 <5 (<5 - <5)
2010-01-01 2010-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 580 <5 <5 <5 (<5 - <5)
2010-02-01 2010-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 566 43.01 5 11,625.47 (3,774.76 - 27,129.98)
2010-03-01 2010-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 554 46.37 5 10,782.60 (3,501.08 - 25,162.99)
2010-04-01 2010-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 539 <5 <5 <5 (<5 - <5)
2010-05-01 2010-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 528 <5 <5 <5 (<5 - <5)
2010-06-01 2010-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 514 <5 <5 <5 (<5 - <5)
2010-07-01 2010-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 501 42.03 6 14,275.86 (5,238.99 - 31,072.53)
2010-08-01 2010-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 489 40.84 5 12,242.00 (3,974.94 - 28,568.74)
2010-09-01 2010-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 473 38.30 5 13,053.13 (4,238.31 - 30,461.64)
2010-10-01 2010-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 458 <5 <5 <5 (<5 - <5)
2010-11-01 2010-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 444 <5 <5 <5 (<5 - <5)
2010-12-01 2010-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 435 36.26 5 13,789.30 (4,477.35 - 32,179.63)
2011-01-01 2011-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 421 <5 <5 <5 (<5 - <5)
2011-02-01 2011-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 410 <5 <5 <5 (<5 - <5)
2011-03-01 2011-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 408 34.07 5 14,675.67 (4,765.15 - 34,248.11)
2011-04-01 2011-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 392 <5 <5 <5 (<5 - <5)
2011-05-01 2011-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 383 <5 <5 <5 (<5 - <5)
2011-06-01 2011-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 373 <5 <5 <5 (<5 - <5)
2011-07-01 2011-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 368 <5 <5 <5 (<5 - <5)
2011-08-01 2011-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 355 <5 <5 <5 (<5 - <5)
2011-09-01 2011-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 348 <5 <5 <5 (<5 - <5)
2011-10-01 2011-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 336 <5 <5 <5 (<5 - <5)
2011-11-01 2011-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 326 <5 <5 <5 (<5 - <5)
2011-12-01 2011-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 314 <5 <5 <5 (<5 - <5)
2008-01-01 2008-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 699 <5 <5 <5 (<5 - <5)
2008-02-01 2008-02-29 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 702 <5 <5 <5 (<5 - <5)
2008-03-01 2008-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 703 58.06 7 12,055.66 (4,847.00 - 24,839.27)
2008-04-01 2008-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 693 55.25 7 12,669.00 (5,093.59 - 26,102.97)
2008-05-01 2008-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 681 <5 <5 <5 (<5 - <5)
2008-06-01 2008-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 683 54.92 7 12,745.58 (5,124.38 - 26,260.77)
2008-07-01 2008-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 677 <5 <5 <5 (<5 - <5)
2008-08-01 2008-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 682 56.56 6 10,607.45 (3,892.75 - 23,087.96)
2008-09-01 2008-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 677 54.43 8 14,696.70 (6,344.99 - 28,958.35)
2008-10-01 2008-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 681 <5 <5 <5 (<5 - <5)
2008-11-01 2008-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 673 <5 <5 <5 (<5 - <5)
2008-12-01 2008-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 677 55.88 8 14,315.88 (6,180.58 - 28,207.99)
2009-01-01 2009-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 668 55.58 7 12,594.91 (5,063.81 - 25,950.33)
2009-02-01 2009-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 656 49.40 6 12,146.73 (4,457.64 - 26,438.32)
2009-03-01 2009-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 648 <5 <5 <5 (<5 - <5)
2009-04-01 2009-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 649 52.01 7 13,458.69 (5,411.09 - 27,730.05)
2009-05-01 2009-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 645 52.99 9 16,983.06 (7,765.73 - 32,239.13)
2009-06-01 2009-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 631 50.56 6 11,867.79 (4,355.27 - 25,831.19)
2009-07-01 2009-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 616 51.49 6 11,652.07 (4,276.10 - 25,361.65)
2009-08-01 2009-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 614 <5 <5 <5 (<5 - <5)
2009-09-01 2009-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 612 49.27 5 10,148.16 (3,295.08 - 23,682.43)
2009-10-01 2009-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 604 <5 <5 <5 (<5 - <5)
2009-11-01 2009-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 603 <5 <5 <5 (<5 - <5)
2009-12-01 2009-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 599 <5 <5 <5 (<5 - <5)
2010-01-01 2010-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 580 <5 <5 <5 (<5 - <5)
2010-02-01 2010-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 566 43.01 5 11,625.47 (3,774.76 - 27,129.98)
2010-03-01 2010-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 554 46.37 5 10,782.60 (3,501.08 - 25,162.99)
2010-04-01 2010-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 539 <5 <5 <5 (<5 - <5)
2010-05-01 2010-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 528 <5 <5 <5 (<5 - <5)
2010-06-01 2010-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 514 <5 <5 <5 (<5 - <5)
2010-07-01 2010-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 501 42.03 6 14,275.86 (5,238.99 - 31,072.53)
2010-08-01 2010-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 489 40.84 5 12,242.00 (3,974.94 - 28,568.74)
2010-09-01 2010-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 473 38.30 5 13,053.13 (4,238.31 - 30,461.64)
2010-10-01 2010-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 458 <5 <5 <5 (<5 - <5)
2010-11-01 2010-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 444 <5 <5 <5 (<5 - <5)
2010-12-01 2010-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 435 36.26 5 13,789.30 (4,477.35 - 32,179.63)
2011-01-01 2011-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 421 <5 <5 <5 (<5 - <5)
2011-02-01 2011-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 410 <5 <5 <5 (<5 - <5)
2011-03-01 2011-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 408 34.07 5 14,675.67 (4,765.15 - 34,248.11)
2011-04-01 2011-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 392 <5 <5 <5 (<5 - <5)
2011-05-01 2011-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 383 <5 <5 <5 (<5 - <5)
2011-06-01 2011-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 373 <5 <5 <5 (<5 - <5)
2011-07-01 2011-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 368 <5 <5 <5 (<5 - <5)
2011-08-01 2011-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 355 <5 <5 <5 (<5 - <5)
2011-09-01 2011-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 348 <5 <5 <5 (<5 - <5)
2011-10-01 2011-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 336 <5 <5 <5 (<5 - <5)
2011-11-01 2011-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 326 <5 <5 <5 (<5 - <5)
2011-12-01 2011-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 0 to 30 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 314 <5 <5 <5 (<5 - <5)
denominator_cohort_2 cohort_1 2008-01-01 2008-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 713 <5 <5 <5 (<5 - <5)
2008-02-01 2008-02-29 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 707 <5 <5 <5 (<5 - <5)
2008-03-01 2008-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 708 58.98 6 10,173.11 (3,733.35 - 22,142.58)
2008-04-01 2008-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 705 <5 <5 <5 (<5 - <5)
2008-05-01 2008-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 703 <5 <5 <5 (<5 - <5)
2008-06-01 2008-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 706 56.85 6 10,554.27 (3,873.23 - 22,972.21)
2008-07-01 2008-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 707 <5 <5 <5 (<5 - <5)
2008-08-01 2008-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 702 <5 <5 <5 (<5 - <5)
2008-09-01 2008-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 694 55.85 8 14,324.85 (6,184.45 - 28,225.67)
2008-10-01 2008-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 684 <5 <5 <5 (<5 - <5)
2008-11-01 2008-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 665 <5 <5 <5 (<5 - <5)
2008-12-01 2008-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 660 54.59 7 12,823.57 (5,155.74 - 26,421.45)
2009-01-01 2009-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 660 <5 <5 <5 (<5 - <5)
2009-02-01 2009-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 652 <5 <5 <5 (<5 - <5)
2009-03-01 2009-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 648 <5 <5 <5 (<5 - <5)
2009-04-01 2009-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 645 51.95 5 9,624.45 (3,125.03 - 22,460.26)
2009-05-01 2009-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 643 <5 <5 <5 (<5 - <5)
2009-06-01 2009-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 652 <5 <5 <5 (<5 - <5)
2009-07-01 2009-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 654 54.36 5 9,198.45 (2,986.71 - 21,466.11)
2009-08-01 2009-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 653 54.20 9 16,605.78 (7,593.22 - 31,522.94)
2009-09-01 2009-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 647 <5 <5 <5 (<5 - <5)
2009-10-01 2009-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 645 53.50 7 13,084.11 (5,260.49 - 26,958.27)
2009-11-01 2009-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 629 50.71 5 9,859.99 (3,201.51 - 23,009.92)
2009-12-01 2009-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 632 <5 <5 <5 (<5 - <5)
2010-01-01 2010-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 620 51.95 6 11,550.01 (4,238.65 - 25,139.51)
2010-02-01 2010-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 607 46.00 7 15,217.72 (6,118.31 - 31,354.32)
2010-03-01 2010-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 591 49.31 6 12,168.16 (4,465.50 - 26,484.97)
2010-04-01 2010-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 575 <5 <5 <5 (<5 - <5)
2010-05-01 2010-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 566 <5 <5 <5 (<5 - <5)
2010-06-01 2010-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 547 <5 <5 <5 (<5 - <5)
2010-07-01 2010-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 538 45.03 6 13,322.97 (4,889.30 - 28,998.50)
2010-08-01 2010-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 527 44.20 5 11,312.99 (3,673.30 - 26,400.73)
2010-09-01 2010-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 516 <5 <5 <5 (<5 - <5)
2010-10-01 2010-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 507 <5 <5 <5 (<5 - <5)
2010-11-01 2010-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 491 <5 <5 <5 (<5 - <5)
2010-12-01 2010-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 482 <5 <5 <5 (<5 - <5)
2011-01-01 2011-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 470 <5 <5 <5 (<5 - <5)
2011-02-01 2011-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 458 <5 <5 <5 (<5 - <5)
2011-03-01 2011-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 446 <5 <5 <5 (<5 - <5)
2011-04-01 2011-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 442 36.13 0 0.00 (0.00 - 10,208.89)
2011-05-01 2011-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 441 <5 <5 <5 (<5 - <5)
2011-06-01 2011-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 431 34.79 5 14,373.18 (4,666.93 - 33,542.22)
2011-07-01 2011-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 420 <5 <5 <5 (<5 - <5)
2011-08-01 2011-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 408 34.00 5 14,705.45 (4,774.82 - 34,317.61)
2011-09-01 2011-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 397 <5 <5 <5 (<5 - <5)
2011-10-01 2011-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 388 <5 <5 <5 (<5 - <5)
2011-11-01 2011-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 379 <5 <5 <5 (<5 - <5)
2011-12-01 2011-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 366 <5 <5 <5 (<5 - <5)
2008-01-01 2008-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 664 <5 <5 <5 (<5 - <5)
2008-02-01 2008-02-29 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 664 <5 <5 <5 (<5 - <5)
2008-03-01 2008-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 669 55.51 6 10,808.28 (3,966.45 - 23,525.07)
2008-04-01 2008-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 671 <5 <5 <5 (<5 - <5)
2008-05-01 2008-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 673 <5 <5 <5 (<5 - <5)
2008-06-01 2008-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 681 54.64 6 10,980.56 (4,029.67 - 23,900.07)
2008-07-01 2008-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 681 <5 <5 <5 (<5 - <5)
2008-08-01 2008-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 683 <5 <5 <5 (<5 - <5)
2008-09-01 2008-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 681 54.61 8 14,650.41 (6,325.00 - 28,867.14)
2008-10-01 2008-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 676 <5 <5 <5 (<5 - <5)
2008-11-01 2008-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 661 <5 <5 <5 (<5 - <5)
2008-12-01 2008-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 658 54.23 7 12,908.22 (5,189.77 - 26,595.87)
2009-01-01 2009-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 658 <5 <5 <5 (<5 - <5)
2009-02-01 2009-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 650 <5 <5 <5 (<5 - <5)
2009-03-01 2009-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 646 <5 <5 <5 (<5 - <5)
2009-04-01 2009-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 644 51.87 5 9,639.67 (3,129.97 - 22,495.77)
2009-05-01 2009-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 642 <5 <5 <5 (<5 - <5)
2009-06-01 2009-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 652 <5 <5 <5 (<5 - <5)
2009-07-01 2009-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 654 54.36 5 9,198.45 (2,986.71 - 21,466.11)
2009-08-01 2009-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 653 54.20 9 16,605.78 (7,593.22 - 31,522.94)
2009-09-01 2009-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 647 <5 <5 <5 (<5 - <5)
2009-10-01 2009-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 644 53.44 7 13,098.07 (5,266.10 - 26,987.02)
2009-11-01 2009-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 628 50.63 5 9,875.96 (3,206.70 - 23,047.19)
2009-12-01 2009-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 631 <5 <5 <5 (<5 - <5)
2010-01-01 2010-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 620 51.94 6 11,550.68 (4,238.90 - 25,140.96)
2010-02-01 2010-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 607 46.00 7 15,217.72 (6,118.31 - 31,354.32)
2010-03-01 2010-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 591 49.31 6 12,168.16 (4,465.50 - 26,484.97)
2010-04-01 2010-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 575 <5 <5 <5 (<5 - <5)
2010-05-01 2010-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 566 <5 <5 <5 (<5 - <5)
2010-06-01 2010-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 547 <5 <5 <5 (<5 - <5)
2010-07-01 2010-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 538 45.03 6 13,322.97 (4,889.30 - 28,998.50)
2010-08-01 2010-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 527 44.20 5 11,312.99 (3,673.30 - 26,400.73)
2010-09-01 2010-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 516 <5 <5 <5 (<5 - <5)
2010-10-01 2010-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 507 <5 <5 <5 (<5 - <5)
2010-11-01 2010-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 491 <5 <5 <5 (<5 - <5)
2010-12-01 2010-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 482 <5 <5 <5 (<5 - <5)
2011-01-01 2011-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 470 <5 <5 <5 (<5 - <5)
2011-02-01 2011-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 458 <5 <5 <5 (<5 - <5)
2011-03-01 2011-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 446 <5 <5 <5 (<5 - <5)
2011-04-01 2011-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 442 36.13 0 0.00 (0.00 - 10,208.89)
2011-05-01 2011-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 440 <5 <5 <5 (<5 - <5)
2011-06-01 2011-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 430 34.70 5 14,407.15 (4,677.96 - 33,621.47)
2011-07-01 2011-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 419 <5 <5 <5 (<5 - <5)
2011-08-01 2011-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 407 33.92 5 14,742.31 (4,786.79 - 34,403.62)
2011-09-01 2011-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 396 <5 <5 <5 (<5 - <5)
2011-10-01 2011-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 386 <5 <5 <5 (<5 - <5)
2011-11-01 2011-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 377 <5 <5 <5 (<5 - <5)
2011-12-01 2011-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 31 to 50 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 364 <5 <5 <5 (<5 - <5)
denominator_cohort_3 cohort_1 2008-01-01 2008-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 669 55.44 5 9,018.60 (2,928.31 - 21,046.40)
2008-02-01 2008-02-29 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 664 51.73 6 11,598.24 (4,256.35 - 25,244.48)
2008-03-01 2008-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 659 <5 <5 <5 (<5 - <5)
2008-04-01 2008-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 650 51.93 7 13,480.72 (5,419.95 - 27,775.44)
2008-05-01 2008-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 638 53.08 6 11,304.54 (4,148.57 - 24,605.23)
2008-06-01 2008-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 635 51.47 5 9,713.64 (3,153.99 - 22,668.40)
2008-07-01 2008-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 641 53.26 7 13,142.58 (5,284.00 - 27,078.73)
2008-08-01 2008-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 642 53.04 5 9,427.20 (3,060.99 - 21,999.95)
2008-09-01 2008-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 631 <5 <5 <5 (<5 - <5)
2008-10-01 2008-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 625 <5 <5 <5 (<5 - <5)
2008-11-01 2008-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 632 <5 <5 <5 (<5 - <5)
2008-12-01 2008-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 626 52.23 6 11,486.99 (4,215.52 - 25,002.34)
2009-01-01 2009-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 627 <5 <5 <5 (<5 - <5)
2009-02-01 2009-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 630 <5 <5 <5 (<5 - <5)
2009-03-01 2009-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 629 51.82 10 19,297.94 (9,254.11 - 35,489.60)
2009-04-01 2009-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 617 49.66 7 14,096.14 (5,667.38 - 29,043.43)
2009-05-01 2009-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 622 <5 <5 <5 (<5 - <5)
2009-06-01 2009-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 618 49.93 6 12,016.82 (4,409.96 - 26,155.57)
2009-07-01 2009-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 618 51.09 8 15,657.42 (6,759.76 - 30,851.35)
2009-08-01 2009-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 617 51.09 5 9,785.89 (3,177.45 - 22,836.99)
2009-09-01 2009-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 609 49.19 9 18,294.91 (8,365.60 - 34,729.45)
2009-10-01 2009-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 613 <5 <5 <5 (<5 - <5)
2009-11-01 2009-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 616 <5 <5 <5 (<5 - <5)
2009-12-01 2009-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 613 <5 <5 <5 (<5 - <5)
2010-01-01 2010-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 601 50.34 5 9,933.45 (3,225.36 - 23,181.35)
2010-02-01 2010-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 588 <5 <5 <5 (<5 - <5)
2010-03-01 2010-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 582 <5 <5 <5 (<5 - <5)
2010-04-01 2010-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 576 <5 <5 <5 (<5 - <5)
2010-05-01 2010-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 575 47.75 6 12,564.39 (4,610.91 - 27,347.39)
2010-06-01 2010-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 557 <5 <5 <5 (<5 - <5)
2010-07-01 2010-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 545 <5 <5 <5 (<5 - <5)
2010-08-01 2010-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 529 <5 <5 <5 (<5 - <5)
2010-09-01 2010-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 522 <5 <5 <5 (<5 - <5)
2010-10-01 2010-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 513 <5 <5 <5 (<5 - <5)
2010-11-01 2010-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 504 40.77 6 14,717.06 (5,400.90 - 32,032.85)
2010-12-01 2010-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 491 <5 <5 <5 (<5 - <5)
2011-01-01 2011-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 481 40.16 7 17,428.54 (7,007.18 - 35,909.46)
2011-02-01 2011-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 470 35.43 5 14,111.14 (4,581.85 - 32,930.69)
2011-03-01 2011-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 463 <5 <5 <5 (<5 - <5)
2011-04-01 2011-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 454 <5 <5 <5 (<5 - <5)
2011-05-01 2011-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 444 <5 <5 <5 (<5 - <5)
2011-06-01 2011-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 434 <5 <5 <5 (<5 - <5)
2011-07-01 2011-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 427 <5 <5 <5 (<5 - <5)
2011-08-01 2011-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 420 <5 <5 <5 (<5 - <5)
2011-09-01 2011-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 410 <5 <5 <5 (<5 - <5)
2011-10-01 2011-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 405 <5 <5 <5 (<5 - <5)
2011-11-01 2011-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 404 <5 <5 <5 (<5 - <5)
2011-12-01 2011-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 397 <5 <5 <5 (<5 - <5)
2008-01-01 2008-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 631 52.18 5 9,581.67 (3,111.14 - 22,360.41)
2008-02-01 2008-02-29 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 631 49.14 6 12,209.51 (4,480.68 - 26,574.97)
2008-03-01 2008-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 631 <5 <5 <5 (<5 - <5)
2008-04-01 2008-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 628 49.95 7 14,014.86 (5,634.70 - 28,875.96)
2008-05-01 2008-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 618 51.32 6 11,692.26 (4,290.85 - 25,449.13)
2008-06-01 2008-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 617 49.98 5 10,004.60 (3,248.47 - 23,347.40)
2008-07-01 2008-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 626 51.99 7 13,465.16 (5,413.69 - 27,743.38)
2008-08-01 2008-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 634 52.16 5 9,586.07 (3,112.57 - 22,370.70)
2008-09-01 2008-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 623 <5 <5 <5 (<5 - <5)
2008-10-01 2008-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 620 <5 <5 <5 (<5 - <5)
2008-11-01 2008-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 630 <5 <5 <5 (<5 - <5)
2008-12-01 2008-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 624 52.10 6 11,515.43 (4,225.96 - 25,064.24)
2009-01-01 2009-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 627 <5 <5 <5 (<5 - <5)
2009-02-01 2009-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 630 <5 <5 <5 (<5 - <5)
2009-03-01 2009-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 629 51.82 10 19,297.94 (9,254.11 - 35,489.60)
2009-04-01 2009-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 617 49.66 7 14,096.14 (5,667.38 - 29,043.43)
2009-05-01 2009-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 622 <5 <5 <5 (<5 - <5)
2009-06-01 2009-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 618 49.93 6 12,016.82 (4,409.96 - 26,155.57)
2009-07-01 2009-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 618 51.09 8 15,657.42 (6,759.76 - 30,851.35)
2009-08-01 2009-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 617 51.09 5 9,785.89 (3,177.45 - 22,836.99)
2009-09-01 2009-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 609 49.19 9 18,294.91 (8,365.60 - 34,729.45)
2009-10-01 2009-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 613 <5 <5 <5 (<5 - <5)
2009-11-01 2009-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 616 <5 <5 <5 (<5 - <5)
2009-12-01 2009-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 613 <5 <5 <5 (<5 - <5)
2010-01-01 2010-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 601 50.34 5 9,933.45 (3,225.36 - 23,181.35)
2010-02-01 2010-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 588 <5 <5 <5 (<5 - <5)
2010-03-01 2010-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 582 <5 <5 <5 (<5 - <5)
2010-04-01 2010-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 576 <5 <5 <5 (<5 - <5)
2010-05-01 2010-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 575 47.75 6 12,564.39 (4,610.91 - 27,347.39)
2010-06-01 2010-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 556 <5 <5 <5 (<5 - <5)
2010-07-01 2010-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 544 <5 <5 <5 (<5 - <5)
2010-08-01 2010-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 529 <5 <5 <5 (<5 - <5)
2010-09-01 2010-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 522 <5 <5 <5 (<5 - <5)
2010-10-01 2010-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 513 <5 <5 <5 (<5 - <5)
2010-11-01 2010-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 504 40.77 6 14,717.06 (5,400.90 - 32,032.85)
2010-12-01 2010-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 490 <5 <5 <5 (<5 - <5)
2011-01-01 2011-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 480 40.08 7 17,465.51 (7,022.04 - 35,985.62)
2011-02-01 2011-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 469 35.36 5 14,141.47 (4,591.70 - 33,001.48)
2011-03-01 2011-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 461 <5 <5 <5 (<5 - <5)
2011-04-01 2011-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 453 <5 <5 <5 (<5 - <5)
2011-05-01 2011-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 443 <5 <5 <5 (<5 - <5)
2011-06-01 2011-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 433 <5 <5 <5 (<5 - <5)
2011-07-01 2011-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 427 <5 <5 <5 (<5 - <5)
2011-08-01 2011-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 419 <5 <5 <5 (<5 - <5)
2011-09-01 2011-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 409 <5 <5 <5 (<5 - <5)
2011-10-01 2011-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 404 <5 <5 <5 (<5 - <5)
2011-11-01 2011-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 403 <5 <5 <5 (<5 - <5)
2011-12-01 2011-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 51 to 70 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 396 <5 <5 <5 (<5 - <5)
denominator_cohort_4 cohort_1 2008-01-01 2008-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 559 <5 <5 <5 (<5 - <5)
2008-02-01 2008-02-29 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 555 <5 <5 <5 (<5 - <5)
2008-03-01 2008-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 560 46.63 5 10,723.17 (3,481.78 - 25,024.30)
2008-04-01 2008-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 561 45.13 8 17,726.18 (7,652.90 - 34,927.63)
2008-05-01 2008-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 556 46.11 8 17,350.57 (7,490.74 - 34,187.54)
2008-06-01 2008-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 555 44.60 6 13,453.82 (4,937.31 - 29,283.30)
2008-07-01 2008-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 555 <5 <5 <5 (<5 - <5)
2008-08-01 2008-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 559 46.63 5 10,723.17 (3,481.78 - 25,024.30)
2008-09-01 2008-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 559 <5 <5 <5 (<5 - <5)
2008-10-01 2008-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 554 46.46 5 10,762.87 (3,494.68 - 25,116.95)
2008-11-01 2008-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 555 44.62 8 17,927.57 (7,739.85 - 35,324.46)
2008-12-01 2008-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 549 <5 <5 <5 (<5 - <5)
2009-01-01 2009-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 551 <5 <5 <5 (<5 - <5)
2009-02-01 2009-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 551 40.97 7 17,087.34 (6,870.00 - 35,206.45)
2009-03-01 2009-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 547 <5 <5 <5 (<5 - <5)
2009-04-01 2009-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 545 <5 <5 <5 (<5 - <5)
2009-05-01 2009-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 553 45.84 6 13,087.58 (4,802.91 - 28,486.15)
2009-06-01 2009-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 545 <5 <5 <5 (<5 - <5)
2009-07-01 2009-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 538 <5 <5 <5 (<5 - <5)
2009-08-01 2009-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 535 44.60 7 15,694.36 (6,309.95 - 32,336.39)
2009-09-01 2009-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 534 43.27 6 13,866.74 (5,088.85 - 30,182.06)
2009-10-01 2009-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 539 <5 <5 <5 (<5 - <5)
2009-11-01 2009-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 537 <5 <5 <5 (<5 - <5)
2009-12-01 2009-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 541 <5 <5 <5 (<5 - <5)
2010-01-01 2010-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 538 44.88 6 13,370.18 (4,906.62 - 29,101.24)
2010-02-01 2010-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 525 <5 <5 <5 (<5 - <5)
2010-03-01 2010-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 514 43.14 6 13,908.21 (5,104.07 - 30,272.31)
2010-04-01 2010-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 504 40.93 5 12,214.78 (3,966.11 - 28,505.23)
2010-05-01 2010-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 497 <5 <5 <5 (<5 - <5)
2010-06-01 2010-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 494 <5 <5 <5 (<5 - <5)
2010-07-01 2010-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 485 <5 <5 <5 (<5 - <5)
2010-08-01 2010-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 484 40.28 6 14,896.10 (5,466.61 - 32,422.54)
2010-09-01 2010-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 472 38.04 5 13,145.10 (4,268.18 - 30,676.27)
2010-10-01 2010-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 460 <5 <5 <5 (<5 - <5)
2010-11-01 2010-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 459 37.24 6 16,112.57 (5,913.03 - 35,070.29)
2010-12-01 2010-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 451 <5 <5 <5 (<5 - <5)
2011-01-01 2011-01-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 445 37.06 7 18,887.27 (7,593.66 - 38,914.99)
2011-02-01 2011-02-28 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 434 32.88 5 15,207.27 (4,937.76 - 35,488.71)
2011-03-01 2011-03-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 426 <5 <5 <5 (<5 - <5)
2011-04-01 2011-04-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 419 <5 <5 <5 (<5 - <5)
2011-05-01 2011-05-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 413 <5 <5 <5 (<5 - <5)
2011-06-01 2011-06-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 411 <5 <5 <5 (<5 - <5)
2011-07-01 2011-07-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 400 <5 <5 <5 (<5 - <5)
2011-08-01 2011-08-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 395 <5 <5 <5 (<5 - <5)
2011-09-01 2011-09-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 386 31.30 6 19,169.94 (7,035.03 - 41,724.89)
2011-10-01 2011-10-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 378 <5 <5 <5 (<5 - <5)
2011-11-01 2011-11-30 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 372 <5 <5 <5 (<5 - <5)
2011-12-01 2011-12-31 incidence IncidencePrevalence 0.8.0 0 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 373 <5 <5 <5 (<5 - <5)
2008-01-01 2008-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 524 <5 <5 <5 (<5 - <5)
2008-02-01 2008-02-29 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 526 <5 <5 <5 (<5 - <5)
2008-03-01 2008-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 534 44.40 5 11,261.26 (3,656.50 - 26,280.03)
2008-04-01 2008-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 536 43.08 8 18,571.40 (8,017.81 - 36,593.05)
2008-05-01 2008-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 533 44.12 8 18,133.19 (7,828.62 - 35,729.61)
2008-06-01 2008-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 537 42.88 6 13,993.52 (5,135.37 - 30,457.99)
2008-07-01 2008-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 536 <5 <5 <5 (<5 - <5)
2008-08-01 2008-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 543 45.11 5 11,084.26 (3,599.03 - 25,866.97)
2008-09-01 2008-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 548 <5 <5 <5 (<5 - <5)
2008-10-01 2008-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 544 45.55 5 10,976.47 (3,564.03 - 25,615.41)
2008-11-01 2008-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 550 44.03 8 18,168.19 (7,843.74 - 35,798.58)
2008-12-01 2008-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 547 <5 <5 <5 (<5 - <5)
2009-01-01 2009-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 551 <5 <5 <5 (<5 - <5)
2009-02-01 2009-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 551 40.97 7 17,087.34 (6,870.00 - 35,206.45)
2009-03-01 2009-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 547 <5 <5 <5 (<5 - <5)
2009-04-01 2009-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 545 <5 <5 <5 (<5 - <5)
2009-05-01 2009-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 553 45.84 6 13,087.58 (4,802.91 - 28,486.15)
2009-06-01 2009-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 545 <5 <5 <5 (<5 - <5)
2009-07-01 2009-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 538 <5 <5 <5 (<5 - <5)
2009-08-01 2009-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 535 44.60 7 15,694.36 (6,309.95 - 32,336.39)
2009-09-01 2009-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 534 43.27 6 13,866.74 (5,088.85 - 30,182.06)
2009-10-01 2009-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 539 <5 <5 <5 (<5 - <5)
2009-11-01 2009-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 537 <5 <5 <5 (<5 - <5)
2009-12-01 2009-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 541 <5 <5 <5 (<5 - <5)
2010-01-01 2010-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 538 44.88 6 13,370.18 (4,906.62 - 29,101.24)
2010-02-01 2010-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 525 <5 <5 <5 (<5 - <5)
2010-03-01 2010-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 514 43.14 6 13,908.21 (5,104.07 - 30,272.31)
2010-04-01 2010-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 504 40.93 5 12,214.78 (3,966.11 - 28,505.23)
2010-05-01 2010-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 496 <5 <5 <5 (<5 - <5)
2010-06-01 2010-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 493 <5 <5 <5 (<5 - <5)
2010-07-01 2010-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 484 <5 <5 <5 (<5 - <5)
2010-08-01 2010-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 484 40.21 6 14,920.18 (5,475.44 - 32,474.94)
2010-09-01 2010-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 472 38.04 5 13,145.10 (4,268.18 - 30,676.27)
2010-10-01 2010-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 460 <5 <5 <5 (<5 - <5)
2010-11-01 2010-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 459 37.24 6 16,112.57 (5,913.03 - 35,070.29)
2010-12-01 2010-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 450 <5 <5 <5 (<5 - <5)
2011-01-01 2011-01-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 444 36.98 7 18,930.69 (7,611.12 - 39,004.45)
2011-02-01 2011-02-28 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 433 32.80 5 15,242.97 (4,949.35 - 35,572.01)
2011-03-01 2011-03-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 425 <5 <5 <5 (<5 - <5)
2011-04-01 2011-04-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 418 <5 <5 <5 (<5 - <5)
2011-05-01 2011-05-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 412 <5 <5 <5 (<5 - <5)
2011-06-01 2011-06-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 410 <5 <5 <5 (<5 - <5)
2011-07-01 2011-07-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 399 <5 <5 <5 (<5 - <5)
2011-08-01 2011-08-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 395 <5 <5 <5 (<5 - <5)
2011-09-01 2011-09-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 385 31.25 6 19,196.93 (7,044.93 - 41,783.63)
2011-10-01 2011-10-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 377 <5 <5 <5 (<5 - <5)
2011-11-01 2011-11-30 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 371 <5 <5 <5 (<5 - <5)
2011-12-01 2011-12-31 incidence IncidencePrevalence 0.8.0 365 FALSE months TRUE 71 to 100 Both 0 2008-01-01 2012-01-01 0 to Inf None 5 371 <5 <5 <5 (<5 - <5)

estimatePointPrevalence() and estimatePeriodPrevalence()

cdm <- mockIncidencePrevalenceRef(
  sampleSize = 50000,
  outPre = 0.5
)

cdm <- generateDenominatorCohortSet(
  cdm = cdm, name = "denominator",
  cohortDateRange = as.Date(c("2008-01-01", "2012-01-01")),
  ageGroup = list(
    c(0, 30),
    c(31, 50),
    c(51, 70),
    c(71, 100)
  )
)
prev <- estimatePointPrevalence(
  cdm = cdm,
  denominatorTable = "denominator",
  outcomeTable = "outcome",
  interval = "Years"
)

estimatePointPrevalence() and estimatePeriodPrevalence()

prev %>%
  glimpse()
Rows: 276
Columns: 13
$ result_id        <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
$ cdm_name         <chr> "mock", "mock", "mock", "mock", "mock", "mock", "mock…
$ group_name       <chr> "denominator_cohort_name", "denominator_cohort_name",…
$ group_level      <chr> "denominator_cohort_1", "denominator_cohort_1", "deno…
$ strata_name      <chr> "overall", "overall", "overall", "overall", "overall"…
$ strata_level     <chr> "overall", "overall", "overall", "overall", "overall"…
$ variable_name    <chr> "outcome_cohort_name", "outcome_cohort_name", "outcom…
$ variable_level   <chr> "cohort_1", "cohort_1", "cohort_1", "cohort_1", "coho…
$ estimate_name    <chr> "denominator_count", "outcome_count", "prevalence", "…
$ estimate_type    <chr> "integer", "integer", "numeric", "numeric", "numeric"…
$ estimate_value   <chr> "755", NA, NA, NA, NA, "708", NA, NA, NA, NA, "670", …
$ additional_name  <chr> "prevalence_start_date &&& prevalence_end_date", "pre…
$ additional_level <chr> "2008-01-01 &&& 2008-01-01", "2008-01-01 &&& 2008-01-…

estimatePointPrevalence() and estimatePeriodPrevalence()

prev <- estimatePeriodPrevalence(
  cdm = cdm,
  denominatorTable = "denominator",
  outcomeTable = "outcome",
  interval = "months"
)

prev %>%
  glimpse()
Rows: 1,136
Columns: 13
$ result_id        <int> 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1,…
$ cdm_name         <chr> "mock", "mock", "mock", "mock", "mock", "mock", "mock…
$ group_name       <chr> "denominator_cohort_name", "denominator_cohort_name",…
$ group_level      <chr> "denominator_cohort_1", "denominator_cohort_1", "deno…
$ strata_name      <chr> "overall", "overall", "overall", "overall", "overall"…
$ strata_level     <chr> "overall", "overall", "overall", "overall", "overall"…
$ variable_name    <chr> "outcome_cohort_name", "outcome_cohort_name", "outcom…
$ variable_level   <chr> "cohort_1", "cohort_1", "cohort_1", "cohort_1", "coho…
$ estimate_name    <chr> "denominator_count", "outcome_count", "prevalence", "…
$ estimate_type    <chr> "integer", "integer", "numeric", "numeric", "numeric"…
$ estimate_value   <chr> "766", NA, NA, NA, NA, "764", NA, NA, NA, NA, "764", …
$ additional_name  <chr> "prevalence_start_date &&& prevalence_end_date", "pre…
$ additional_level <chr> "2008-01-01 &&& 2008-01-31", "2008-01-01 &&& 2008-01-…

estimatePointPrevalence() and estimatePeriodPrevalence()

plot <- plotPrevalence(prev,
              facet = "denominator_age_group")

estimatePointPrevalence() and estimatePeriodPrevalence()

plot

Your turn

Using the Eunomia data:

  1. Create a denominator cohort, starting from 1st January 2020

  2. Create an outcome cohort of acetaminophen users

  3. Estimate incidence and plot the result

Package website

https://darwin-eu.github.io/IncidencePrevalence/

Package paper

https://onlinelibrary.wiley.com/doi/10.1002/pds.5717